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Cardiorespiratory fitness trumps BMI in predicting risk of death and heart disease

As rates of obesity, as defined by body mass index (BMI), continue to climb in the United States, so have efforts to lose weight, including a new era of weight-loss drugs.

20 Nov 2024

Experts identify five elements of brain-based visual impairment in children

Experts convened by the National Institutes of Health (NIH) have identified five elements of a brain-based condition that has emerged as a leading cause of vision impairment starting in childhood in the United States and other industrialized nations.

20 Nov 2024

More than half of all US adults are eligible for semaglutide therapy

Over 137 million US adults are eligible for semaglutide, driven by expanding indications for diabetes, weight management, and cardiovascular disease prevention.

20 Nov 2024

SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses

SARS-CoV-2 disrupts cholesterol metabolism by using its ORF3a protein to sequester cholesterol in lysosomes, reducing BMP levels and optimizing viral survival. This novel mechanism offers insights into long-term metabolic complications of COVID-19.

19 Nov 2024

Kyushu University team develops antibody to fight age-related muscle atrophy

We all age. And while humanity's life expectancy has increased dramatically in the modern era, we still struggle with the inevitable health issues our bodies face as we get up in the years.

19 Nov 2024

New protein target offers promise for alleviating cognitive decline in Parkinson's disease

A recently published study by researchers at the University of Arizona Health Sciences found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.

19 Nov 2024

Study investigates impact of oxygen therapy on oxidative stress in patients with COVID-19 pneumonia

Severe COVID-19 pneumonia often requires high concentrations of oxygen, which can potentially lead to oxidative stress and lung injury.

19 Nov 2024

New research links sphingolipids to heart disease and atherosclerosis

Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns.

19 Nov 2024

Study provides insight into how low-dose ketamine alleviates symptoms of major depression

University at Buffalo neuroscientists have identified the binding site of low-dose ketamine, providing critical insight into how the medication, often described as a wonder drug, alleviates symptoms of major depression in as little as a few hours with effects lasting for several days.

19 Nov 2024

Research uncovers how inhaled house dust mites trigger of allergic asthma

New research from the University of Pittsburgh uncovers how inhaled house dust mites, a common trigger of allergic asthma, activate the immune system and drive this disease in mice.

19 Nov 2024

Study reveals variability in polygenic risk scores for predicting heart disease

Polygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person's risk of developing certain diseases, such as coronary artery disease (CAD).

19 Nov 2024

New CAR T-cell therapy shows promise against aggressive HER2+ breast cancer

One-third of HER2-positive (HER2+) tumors express the P95HER2 protein, which associates with an aggressive form of breast cancer with a poorer prognosis. Investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Growth Factors Group, in collaboration with researchers of the Cancer Research Program of Hospital del Mar Research Institute (HMRI), Barcelona, have developed novel chimeric antigen receptor (CAR) T-cell therapy that can produce a potent antitumor response against p95HER2-expressing cells.

19 Nov 2024

Malaria crystal structure offers clues for more effective medications

Prof. Leslie Leiserowitz first became intrigued by malaria when he was a young boy in South Africa. His father, who scouted the continent in search of wood for the family business, brought back not only tales of elephants and gorillas but also skin rashes and ringing in his ears, side effects of the quinine he took to prevent malaria.

19 Nov 2024