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Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.

27 Jun 2024

Study identifies mechanism that impedes the effectiveness of melanoma therapies

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance.

27 Jun 2024

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Schizophrenia is a complicated mental health disorder accompanied by wide range of symptoms such as hallucinations, impaired cognitive ability, and disorganized speech or behavior.

27 Jun 2024

Chronic loneliness associated with higher stroke risk independent of depressive symptoms or social isolation

Researchers determined the relationship between loneliness and incident stroke risk in the United States.

27 Jun 2024

AI breakthrough: Speech analysis predicts Alzheimer's progression with 78.5% accuracy

A method for predicting Alzheimer’s disease (AD) progression.

27 Jun 2024

Diabetes decoded: How your gut microbiome influences disease risk

How microbial features and functions specific to subspecies and strains contribute to the pathological mechanisms of type 2 diabetes.

27 Jun 2024

New-onset anxiety in adults aged 50+ doubles risk of developing Parkinson's disease

Researchers investigated Parkinson's disease (PD) risk among individuals with new-onset anxiety and associated risk factors.

27 Jun 2024

Study shows high rates of unrecognized heart valve disease in healthy seniors

The sheer scale of undiagnosed heart valve disease in our ageing population has been revealed for the first time, thanks to new research led by the University of East Anglia.

27 Jun 2024

Study identifies key neurons controlling threat response and escape in mice

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behaviour in mice. These findings could help unlock new directions for discovering therapies for anxiety and post-traumatic stress disorder (PTSD).

27 Jun 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours-;sometimes more than a day-;in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

Amorphous calcium phosphate drives aortic valve stiffening

The human body has sophisticated defenses against the deposition of calcium minerals that stiffen heart tissues, researchers at the University of Illinois Urbana-Champaign and collaborators at UCLA Health and the University of Texas at Austin found in a new study that provides the first detailed, step-by-step documentation of how calcification progresses.

27 Jun 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

Early diagnosis key in combating the deadly effects of AL amyloidosis

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death.

27 Jun 2024

UBC researchers use AI to improve endometrial cancer diagnosis and treatment

A discovery by researchers at the University of British Columbia promises to improve care for patients with endometrial cancer, the most common gynecologic malignancy.

27 Jun 2024

Evaluating CGM accuracy and benefits in non-diabetic populations

A new narrative review led by researchers at UCL and Birmingham Children's Hospital has found there is a lack of evidence to demonstrate the effective use of continuous glucose monitors (CGMs) in people not living with diabetes (PNLD).

27 Jun 2024

Rapeseed diacylglycerol oil may combat obesity by enhancing lipid metabolism

A study in "Nutrients" explores how rapeseed diacylglycerol oil (RDG) affects fat accumulation and metabolism in obese mice, showing significant benefits in reducing obesity-related indices and improving lipid metabolism.

26 Jun 2024

Specific bacteria in the gut associated with food addiction

An international team of researchers has identified specific bacteria in the gut that are associated with both mice and humans developing an addiction to food that can lead to obesity.

26 Jun 2024

CRISPR-based genetic technique eradicates malaria mosquitoes with over 99% efficiency

Scientists at the University of California have developed a precision-guided sterile insect technique to eliminate Anopheles gambiae mosquitoes, achieving over 99.5% male sterility and 99.9% female lethality, effectively suppressing malaria transmission.

26 Jun 2024

Tai Chi and cognitive behavioral therapy can reduce insomnia, inflammation in breast cancer survivors

New research led by UCLA Health confirms that both Tai Chi and cognitive behavioral therapy can reduce insomnia in breast cancer survivors but also may provide additional health benefits by reducing inflammation and bolstering anti-viral defenses.

26 Jun 2024

Duke researchers discover drug to restore aged livers

While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure.

26 Jun 2024