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Researchers reveal key factor in understanding elevated cancer risk linked to gene therapy

National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping their findings may eventually help improve gene therapy for humans. Researchers at the National Human Genome Research Institute, part of NIH, published their research in the Jan. 20, 2015, online issue of the Journal of Clinical Investigation.

21 Jan 2015

Changes in current Ebola virus epidemic could potentially interfere with experimental treatments

Researchers have tracked the genetic mutations that have occurred in the Ebola virus during the last four decades. Their findings, published in mBio, the online open-access journal of the American Society for Microbiology, identified changes in the current West African outbreak strain that could potentially interfere with experimental, sequence-based therapeutics.

21 Jan 2015

Understanding heart mutations that cause sudden cardiac arrest

New biosciences research at the University of Kent could point the way to greater understanding of the heart mutations that cause sudden cardiac arrest.

20 Jan 2015

Researchers identify ten new antibodies that can possibly prevent cancer tumours

Out of a library with billions of artificial antibodies, researchers have identified ten that can possibly prevent cancer tumours from growing.

20 Jan 2015

Researchers explore how M6P deficiency affects different kinds of immune cells

A group of white blood cells known as B cells, which play a key role in the human immune response, need a protein-targeting signal called mannose 6-phosphate (M6P) in order to proliferate, differentiate, and present immune cell-activating antigens, according to a study in The Journal of Cell Biology.

20 Jan 2015

UPM researchers study stability of arsenic species in edible marine algae

Researchers at UPM have studied the stability of diverse arsenic species found in edible marine algae and have established the best conditions for their storage and preservation.

20 Jan 2015

QMUL researchers develop new 'microcapsule' method to treat osteoarthritis

A new 'microcapsule' treatment delivery method developed by researchers at Queen Mary University of London could reduce inflammation in cartilage affected by osteoarthritis and reverse damage to tissue. The research was funded by Arthritis Research UK and the AO Foundation.

20 Jan 2015

Researchers identify novel life-preserving circuit responsible for recognizing threats

Our existence depends on a bit of evolutionary genius aptly nicknamed "fight or flight." But where in our brain does the alarm first go off, and what other parts of the brain are mobilized to express fear and remember to avoid danger in the future?

20 Jan 2015

Research opens door to potential new cancer biomarkers

A new analysis opens the door to discovery of thousands of potential new cancer biomarkers.

20 Jan 2015

Researchers identify novel signaling pathway that triggers allergic asthma response

Researchers at the University of California, San Diego School of Medicine, with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma.

20 Jan 2015

Study unveils genetic architecture that enables parasite to develop antimalarial drug resistance

The largest genome-wide association study to date of the malaria parasite Plasmodium falciparum unveils a complex genetic architecture that enables the parasite to develop resistance to our most effective antimalarial drug, artemisinin. The results could help to improve early detection of emerging artemisinin resistance.

20 Jan 2015

CUMC researcher develops new 3D microscope that can help view living things at very high speeds

Opening new doors for biomedical and neuroscience research, Elizabeth Hillman, associate professor of biomedical engineering at Columbia Engineering and of radiology at Columbia University Medical Center, has developed a new microscope that can image living things in 3D at very high speeds.

20 Jan 2015

Brains of individuals with ASD display unique synchronization patterns

Autism Spectrum Disorder (ASD) has been studied for many years, but there are still many more questions than answers. For example, some research into the brain functions of individuals with autism spectrum have found a lack of synchronization ('connectivity') between different parts of the brain that normally work in tandem.

20 Jan 2015

Brain uses separate pathway to recall old fear memories

People with anxiety disorders, such as post traumatic stress disorder (PTSD), often experience prolonged and exaggerated fearfulness. Now, an animal study suggests that this might involve disruption of a gradual shifting of brain circuitry for retrieving fear memories. Researchers funded by the National Institutes of Health have discovered in rats that an old fear memory is recalled by a separate brain pathway from the one originally used to recall it when it was fresh.

20 Jan 2015

Researchers find genetic mutation that causes glycogen storage disease type IIIa in Inuit

A team of Canadian and Japanese researchers has identified the genetic mutation responsible for glycogen storage disease type IIIa in Inuit in northern Quebec, Canada, in a study published in CMAJ (Canadian Medical Association Journal).

20 Jan 2015

Study suggests that common gut microbe may control risk of developing MS

A common gut microbe might curb the risk of developing multiple sclerosis--at least in women--suggests the largest study of its kind published online in the Journal of Neurology Neurosurgery & Psychiatry.

20 Jan 2015

CSHL researchers describe new pathway that controls fear memories in the mouse brain

Some people have no fear, like that 17-year-old kid who drives like a maniac. But for the nearly 40 million adults who suffer from anxiety disorders, an overabundance of fear rules their lives. Debilitating anxiety prevents them from participating in life's most mundane moments, from driving a car to riding in an elevator.

20 Jan 2015

Penn State researchers explore benefits of beet juice

Athletes who down beet juice before exercising to increase blood flow and improve performance may be surprised at the results of a recent study conducted at Penn State's Noll Laboratory. While beetroot juice rich in nitrates did not enhance muscle blood flow or vascular dilation during exercise, researchers found that it did "de-stiffen" blood vessels under resting conditions, potentially easing the workload of the heart.

20 Jan 2015

Tiny lumps of calcium phosphate may trigger age-related macular degeneration

New research from scientists at the University of Maryland School of Medicine has found that tiny lumps of calcium phosphate may be an important triggering factor for age-related macular degeneration (AMD), a degenerative eye disease that can cause severe vision loss and blindness.

20 Jan 2015

Study leads to discovery of rare genetic disorder

Recently, a grassroots effort initiated by families and clinicians led to the discovery of a human genetic disorder with severe consequences that is linked to a mutation in the human NGLY1 gene. In a big step towards understanding the effects of this mutation, research by scientists at the RIKEN-Max Planck Joint Research Center in Japan implicates the enzyme ENGase as the factor responsible for deficient protein degradation that occurs in the absence of mouse Ngly1 gene expression.

19 Jan 2015

Medical Science News

Researchers reveal key factor in understanding elevated cancer risk linked to gene therapy

Changes in current Ebola virus epidemic could potentially interfere with experimental treatments

Understanding heart mutations that cause sudden cardiac arrest

Researchers identify ten new antibodies that can possibly prevent cancer tumours

Researchers explore how M6P deficiency affects different kinds of immune cells

UPM researchers study stability of arsenic species in edible marine algae

QMUL researchers develop new 'microcapsule' method to treat osteoarthritis

Researchers identify novel life-preserving circuit responsible for recognizing threats

Research opens door to potential new cancer biomarkers

Researchers identify novel signaling pathway that triggers allergic asthma response

Study unveils genetic architecture that enables parasite to develop antimalarial drug resistance

CUMC researcher develops new 3D microscope that can help view living things at very high speeds

Brains of individuals with ASD display unique synchronization patterns

Brain uses separate pathway to recall old fear memories

Researchers find genetic mutation that causes glycogen storage disease type IIIa in Inuit

Study suggests that common gut microbe may control risk of developing MS

CSHL researchers describe new pathway that controls fear memories in the mouse brain

Penn State researchers explore benefits of beet juice

Tiny lumps of calcium phosphate may trigger age-related macular degeneration

Study leads to discovery of rare genetic disorder

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This International Women’s Day, Meet the Scientist Changing Women’s Healthcare

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