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Investigators isolate protein that is responsible for fungus' ability to cross blood-brain barrier

In a remarkable series of experiments on a fungus that causes cryptococcal meningitis, a deadly infection of the membranes that cover the spinal cord and brain, investigators at UC Davis have isolated a protein that appears to be responsible for the fungus' ability to cross from the bloodstream into the brain.

13 Jun 2014

Excessive abuse of alcohol causes structural damage at molecular level to the brain

Joint research between the University of the Basque Country (UPV/EHU) and the University of Nottingham has identified, for the first time, the structural damage caused at a molecular level to the brain by the chronic excessive abuse of alcohol.

13 Jun 2014

Human mind can rapidly absorb new information by synchronization of brain waves

The human mind can rapidly absorb and analyze new information as it flits from thought to thought. These quickly changing brain states may be encoded by synchronization of brain waves across different brain regions, according to a new study from MIT neuroscientists.

13 Jun 2014

Proteins causing daytime sleepiness also play crucial role in bone formation

Orexin proteins, which are blamed for spontaneous daytime sleepiness, also play a crucial role in bone formation, according to findings by UT Southwestern Medical Center researchers.

13 Jun 2014

BRI researchers use tetramer technology to find T cells that drive rheumatoid arthritis

Researchers at Benaroya Research Institute at Virginia Mason used cutting-edge tetramer technology developed at BRI to find the T cells that drive rheumatoid arthritis (RA). "By using tetramer technology, we were able to examine whether T cells in people with rheumatoid arthritis were increased in number or were unique in other ways," says BRI Associate Director Jane Buckner, MD, who led the study with BRI Tetramer Core Laboratory Manager Eddie James, PhD.

12 Jun 2014

Tufts researchers gain new insight into protein associated with bipolar disorder

Researchers from Tufts have gained new insight into a protein associated with bipolar disorder. The study, published in the June 3 issue of Science Signaling, reveals that calcium channels in resting neurons activate the breakdown of Sp4, which belongs to a class of proteins called transcription factors that regulate gene expression.

12 Jun 2014

New path may lead to powerful adjunctive novel therapy for PTSD treatment

There are currently only two FDA-approved medications for the treatment of posttraumatic stress disorder (PTSD) in the United States. Both of these medications are serotonin uptake inhibitors. Despite the availability of these medications, many people diagnosed with PTSD remain symptomatic, highlighting the need for new medications for PTSD treatment.

12 Jun 2014

DNA methylation identified as potential anti-TNF response biomarker for RA

DNA methylation has been identified as a potential biomarker of response to etanercept and adalimumab in patients with rheumatoid arthritis (RA) according to preliminary results from one of the largest methylome-wide investigations of treatment response to anti-TNF therapies.

12 Jun 2014

People with obesity gene FTO tend to gain more weight as they age

A new study from Uppsala University demonstrates that elderly humans carrying a common variant of the fat mass and obesity gene FTO also have a shifted endocrine balance. Low blood concentrations of the satiety hormone leptin and high blood concentrations of the hunger promoting hormone ghrelin makes carriers of the FTO gene put on weight.

12 Jun 2014

Exercise transiently suppresses inflammation in rheumatic disease

Research findings presented today at the European League Against Rheumatism Annual Congress suggest that exercise transiently suppresses local and systemic inflammation, reinforcing the beneficial effects of exercise and the need for this to be regular in order to achieve clinical efficacy in rheumatic disease.

12 Jun 2014

Study examines effect of phthalate exposure in humans’ sperm epigenetics

A new three-year, $440,000 study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst is now underway to investigate whether phthalate levels in expectant fathers have an effect on the couples' reproductive success, via epigenetic modifications of sperm DNA.

12 Jun 2014

Intake of monounsaturated fatty acids, cholesterol influence disease activity in RA and OA respectively

Two new studies presented today at the European League Against Rheumatism Annual Congress have helped clarify the relationship between the dietary intake of monounsaturated fatty acids and cholesterol with disease activity in rheumatoid arthritis (RA) and osteoarthritis (OA) respectively.

12 Jun 2014

TxCell receives Certificate of GMP compliance for cell therapy manufacturing facility in France

TxCell SA, a biotechnology company developing innovative, personalized cell-based immunotherapies using antigen specific regulatory T-cells (Ag-Tregs) for severe chronic inflammatory and autoimmune diseases, announces today that it has been granted Certificate of Good Manufacturing Practice (GMP) compliance for its cell therapy manufacturing facility in Besançon, France.

12 Jun 2014

Leica Application Suite Advanced Fluorescence 4.0 now launched for advanced life science research

Leica Microsystems has launched the Leica Application Suite Advanced Fluorescence (LAS AF), the software platform for advanced life science research in widefield and confocal microscopy, in its 4.0 version.

12 Jun 2014

Study identifies correlation between miRNAs and osteoarthritis

The results of a study presented today at the European League Against Rheumatism Annual Congress identify a correlation between the presence of biomarkers in the blood, known as micro RNAs (miRNAs), and the development of severe osteoarthritis (OA) of the knee or hip joint. The findings suggest that miRNAs may be used as biomarkers to predict severe OA disease in individuals.

12 Jun 2014

New educational programs aim to integrate genetics and genomics into medicine

The American Society of Human Genetics and The Jackson Laboratory announced today a formal collaboration under which the two organizations will produce and deliver high-quality educational programs to integrate genetic and genomic advances into healthcare.

11 Jun 2014

Researchers study structural aspects of DNA-particle/lipid interface directly using x-ray scattering

Scientists seeking ways to engineer the assembly of tiny particles measuring just billionths of a meter have achieved a new first-the formation of a single layer of nanoparticles on a liquid surface where the properties of the layer can be easily switched.

11 Jun 2014

Novel bone implants can keep germs at bay

Hospital germs can be fatal, since they are resistant to antibiotics. As a result, alternative methods of defense against bacteria are in demand. Fortunately, a German-French research team has been able to develop bone implants that keep the germs at bay.

11 Jun 2014

Molecular mechanisms regulating tumour initiation in skin SCC uncovered

Advanced online publication in Nature: Researchers at the Université libre de Bruxelles, ULB uncover the molecular mechanisms regulating tumour initiation and cancer stem cells functions in skin squamous cell carcinoma.

11 Jun 2014

Modified mosquitoes produce sperm that only creates males

Scientists have modified mosquitoes to produce sperm that will only create males, pioneering a fresh approach to eradicating malaria.

11 Jun 2014

Medical Science News

Investigators isolate protein that is responsible for fungus' ability to cross blood-brain barrier

Excessive abuse of alcohol causes structural damage at molecular level to the brain

Human mind can rapidly absorb new information by synchronization of brain waves

Proteins causing daytime sleepiness also play crucial role in bone formation

BRI researchers use tetramer technology to find T cells that drive rheumatoid arthritis

Tufts researchers gain new insight into protein associated with bipolar disorder

New path may lead to powerful adjunctive novel therapy for PTSD treatment

DNA methylation identified as potential anti-TNF response biomarker for RA

People with obesity gene FTO tend to gain more weight as they age

Exercise transiently suppresses inflammation in rheumatic disease

Study examines effect of phthalate exposure in humans’ sperm epigenetics

Intake of monounsaturated fatty acids, cholesterol influence disease activity in RA and OA respectively

TxCell receives Certificate of GMP compliance for cell therapy manufacturing facility in France

Leica Application Suite Advanced Fluorescence 4.0 now launched for advanced life science research

Study identifies correlation between miRNAs and osteoarthritis

New educational programs aim to integrate genetics and genomics into medicine

Researchers study structural aspects of DNA-particle/lipid interface directly using x-ray scattering

Novel bone implants can keep germs at bay

Molecular mechanisms regulating tumour initiation in skin SCC uncovered

Modified mosquitoes produce sperm that only creates males

This International Women’s Day, Meet the Scientist Changing Women’s Healthcare

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

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