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Research to understand how low blood sugars cause irregular heartbeats in diabetes

Dangerous overnight blood sugar levels often go undetected and cause prolonged periods of heart rhythm disturbances in older patients with Type 2 diabetes and associated heart problems, new research reveals.

29 Apr 2014

BRCA gene loss may accelerate cancer-promoting chromosome rearrangements

Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors to hereditary cancer risk in the human population, often causing breast or ovarian cancer in young women of child-bearing age.

29 Apr 2014

Scientists use analysis of epigenetic marks on DNA to measure baby's development in womb

An international study, involving scientists at the University of Southampton, has used an analysis of epigenetic marks on DNA to measure how much a baby's development in the womb is determined by the genes inherited from the parents, as compared with the mother's nutrition, mental health and lifestyle.

28 Apr 2014

Life stressors may activate neurological disorders

When mothers are exposed to trauma, illness, alcohol or other drug abuse, these stressors may activate a single molecular trigger in brain cells that can go awry and activate conditions such as schizophrenia, post-traumatic stress disorder and some forms of autism.

26 Apr 2014

Finnish researchers discover gene mutation in ameloblastoma

A Finnish team of researchers was the first in the world to discover a gene mutation in ameloblastoma, which is a tumour of the jaw.

26 Apr 2014

Experts to discuss solutions for brain-related challenges at inaugural Brain Health Summit

On April 28, the Center for BrainHealth will bring together national experts to discuss solutions to our most pressing brain-related challenges at its inaugural Brain Health Summit, titled "The Human Brain: Resilience and Regeneration."

26 Apr 2014

Novel technique tests brain waves as external stimuli are processed

Have you ever accidently missed a red light or a stop sign? Or have you heard someone mention a visible event that you passed by but totally missed seeing?

26 Apr 2014

Cells are more resilient than originally thought, say scientists

New research shows that cells are more resilient in taking care of their DNA than scientists originally thought. Even when missing critical components, cells can adapt and make copies of their DNA in an alternative way.

26 Apr 2014

Researchers use RNA sequencing to look at early- and late-stage development of the heart

Most people think the development of the heart only happens in the womb, however the days and weeks following birth are full of cellular changes that play a role in the structure and function of the heart. Using mouse models, researchers at Baylor College of Medicine have now been able to categorize the alternative splicing (the process in which genes code proteins, determining their role) that takes place during these changes and what mechanisms they affect.

26 Apr 2014

University of Michigan scientists uncover how cells block mutation-causing activity of junk DNA

There's a civil war going on inside every one of the 37 trillion cells in your body. Now, University of Michigan scientists have uncovered how your cells keep this war from causing too much collateral damage.

26 Apr 2014

Genetically modified E. coli has ability to produce D-ribose

D-ribose is a commercially important sugar used as a sweetener, a nutritional supplement, and as a starting compound for synthesizing riboflavin and several antiviral drugs.

26 Apr 2014

Biologists identify how T-type channels change electrochemical signaling of heart and brain cells

Biologists have discovered how an outer shield over T-type channels change the electrochemical signaling of heart and brain cells. Understanding how these shields work will help researchers eventually develop a new class of drugs for treating epilepsy, cardiovascular disease and cancer.

26 Apr 2014

Stem cell production becomes much easier with polymer-based 3D culture system

Mass producing human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, for regenerative medicine and drug discovery may have gotten much easier, thanks to a polymer-based 3D culture system developed by Japanese researchers.

26 Apr 2014

Johns Hopkins research may help manage the disruptive effects experienced by shift workers

Johns Hopkins researchers report that they have identified a protein essential to the formation of the tiny brain region in mice that coordinates sleep-wake cycles and other so-called circadian rhythms.

26 Apr 2014

Graphene may lead to new applications in the diagnosis and treatment of neurological diseases

The development of graphene-a highly advanced metamaterial with many unique and varied properties-may lead to exciting new applications in the diagnosis and treatment of neurological diseases, according to a report in the May issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

26 Apr 2014

Study could lead to better understanding of how Notch protein directs healthy development of organs

Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports, the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys.

26 Apr 2014

Findings shed light on evolution of mammalian behaviors and their brain mechanisms

A team led by scientists at The Scripps Research Institute has deciphered the surprisingly versatile code by which chemical cues help trigger some of the most basic behaviors in mice.

26 Apr 2014

Discovery offers potential target for reversing progression of end-stage liver disease

A team of researchers in the University of Arizona's College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse the progression of end-stage liver disease.

26 Apr 2014

MGH investigators develop next-generation genome editing system

A next-generation genome editing system developed by Massachusetts General Hospital investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology, the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites.

26 Apr 2014

Junk DNA linked to heart failure, reveals Washington University study

Large sections of the genome that were once referred to as "junk" DNA have been linked to human heart failure, according to research from Washington University School of Medicine in St. Louis.

26 Apr 2014

Medical Science News

Research to understand how low blood sugars cause irregular heartbeats in diabetes

BRCA gene loss may accelerate cancer-promoting chromosome rearrangements

Scientists use analysis of epigenetic marks on DNA to measure baby's development in womb

Life stressors may activate neurological disorders

Finnish researchers discover gene mutation in ameloblastoma

Experts to discuss solutions for brain-related challenges at inaugural Brain Health Summit

Novel technique tests brain waves as external stimuli are processed

Cells are more resilient than originally thought, say scientists

Researchers use RNA sequencing to look at early- and late-stage development of the heart

University of Michigan scientists uncover how cells block mutation-causing activity of junk DNA

Genetically modified E. coli has ability to produce D-ribose

Biologists identify how T-type channels change electrochemical signaling of heart and brain cells

Stem cell production becomes much easier with polymer-based 3D culture system

Johns Hopkins research may help manage the disruptive effects experienced by shift workers

Graphene may lead to new applications in the diagnosis and treatment of neurological diseases

Study could lead to better understanding of how Notch protein directs healthy development of organs

Findings shed light on evolution of mammalian behaviors and their brain mechanisms

Discovery offers potential target for reversing progression of end-stage liver disease

MGH investigators develop next-generation genome editing system

Junk DNA linked to heart failure, reveals Washington University study

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

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