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Tumor-suppressing protein acts as dimmer switch to dial down gene expression

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014.

11 Apr 2014

Scientists solve a decades-long mystery of cell biology

A team led by scientists at The Scripps Research Institute has identified a long-sought protein that facilitates one of the most basic functions of cells: regulating their volume to keep from swelling excessively.

11 Apr 2014

Researchers identify biological process that appears to trigger Parkinson's disease

Working with human neurons and fruit flies, researchers at Johns Hopkins have identified and then shut down a biological process that appears to trigger a particular form of Parkinson's disease present in a large number of patients. A report on the study, in the April 10 issue of the journal Cell, could lead to new treatments for this disorder.

11 Apr 2014

Two Penn researchers selected as recipients of prestigious Clinical Research Achievement Award

Two researchers from the Perelman School of Medicine at the University of Pennsylvania and the Penn Cardiovascular Institute are among the 2014 recipients of the prestigious Clinical Research Achievement Award for their work in cardiovascular science.

11 Apr 2014

Acupuncture protects brain neurons against injury in rats following heroin relapse

Heroin abuse can damage many brain areas, including the pedunculopontine tegmental nucleus of the midbrain, the ventral tegmental area, and nucleus accumbens. Persistent use of heroin induced irreversible damage to the nervous system.

11 Apr 2014

Researchers untangle genetic and environmental factors related to drug reactions

Why do people respond differently to the same drug? For the first time, researchers have untangled genetic and environmental factors related to drug reactions, bringing us a step closer to predicting how a drug will affect us.

11 Apr 2014

Researchers discover mechanism that control normal lung function in patients with BHD syndrome

Researchers at Penn Medicine have discovered that the tumor suppressor gene folliculin (FLCN) is essential to normal lung function in patients with the rare disease Birt-Hogg-Dube (BHD) syndrome, a genetic disorder that affects the lungs, skin and kidneys. Folliculin's absence or mutated state has a cascading effect that leads to deteriorated lung integrity and an impairment of lung function, as reported in their findings in the current issue of Cell Reports.

11 Apr 2014

Human testes respond differently to endocrine disrupting chemicals

Human and rat testes respond differently to endocrine disrupting chemicals such as BPA in two thirds of all cases, according to a recent review. As human safety levels are extrapolated from rodent data, the study could lead to a re-evaluation of the acceptable daily intake for many endocrine disruptors.

10 Apr 2014

Researchers reveal how cells respond to mechanical manipulation

The push and pull of physical force can cause profound changes in the behavior of a cell. Two studies from researchers working at the UNC Lineberger Comprehensive Cancer Center reveal how cells respond to mechanical manipulation

10 Apr 2014

Snack food with olestra speeds up removal of toxins in body

According to a clinical trial led by University of Cincinnati researchers, a snack food ingredient called olestra has been found to speed up the removal of toxins in the body.

10 Apr 2014

Researchers find that cancer gene require copper to promote tumor growth

Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers at Duke Medicine report.

10 Apr 2014

Scientists design new system for molecular blood group typing

Scientists in France have designed a new system for molecular blood group typing that offers blood banks the possibility of extensive screening of blood donors at a relatively low cost. Their approach is described in the current issue of The Journal of Molecular Diagnostics.

10 Apr 2014

Researcher develops synthetic hydrogel that promotes natural clotting, heals surgical wounds

Synthetic collagen invented at Rice University may help wounds heal by directing the natural clotting of blood.

10 Apr 2014

Research finding sheds more light on cancer development and metastasis

10 Apr 2014

Researcher analyses effect of chromium supplementation on blood sugar

Approximately 26 percent of the U.S. population has impaired fasting glucose, which is a predisposition for developing type 2 diabetes, and chromium supplementation has been suggested as a method that may help control and prevent the disease.

10 Apr 2014

Study describes how overeating causes brown fat cells to "whiten"

Boston University researchers have learned new information about the consequences of overeating high-calorie foods. Not only does this lead to an increase in white fat cell production, the type prominent in obesity, but it also leads to the dysfunction of brown fat cells, the unique type of fat that generates heat and burns energy.

10 Apr 2014

Stem cells culled from bone marrow may prove beneficial in stroke recovery

Stem cells culled from bone marrow may prove beneficial in stroke recovery, scientists at UC Irvine's Sue & Bill Gross Stem Cell Research Center have learned.

10 Apr 2014

Stressful upbringings can leave imprints on genes of African American children

Stressful upbringings can leave imprints on the genes of children as young as age 9, according to a study led by Princeton University and Pennsylvania State University researchers. Such chronic stress during youth leads to physiological weathering similar to aging.

10 Apr 2014

Multiple genomic data could help improve studies of association between genes and disease

The difference between merely throwing around buzzwords like "personalized medicine" and "big data" and delivering on their medical promise is in the details of developing methods for analyzing and interpreting genomic data. In a pair of new papers, Brown University epidemiologist Yen-Tsung Huang and colleagues show how integrating different kinds of genomic data could improve studies of the association between genes and disease.

10 Apr 2014

Study identifies two cell surface receptors that may be responsible for spread of lung cancer

Two cell surface receptors might be responsible for the most common form of lung cancer spreading to other parts of the body, according to a study led by the Translational Genomics Research Institute.

10 Apr 2014

Medical Science News

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

Scientists solve a decades-long mystery of cell biology

Researchers identify biological process that appears to trigger Parkinson's disease

Two Penn researchers selected as recipients of prestigious Clinical Research Achievement Award

Acupuncture protects brain neurons against injury in rats following heroin relapse

Researchers untangle genetic and environmental factors related to drug reactions

Researchers discover mechanism that control normal lung function in patients with BHD syndrome

Human testes respond differently to endocrine disrupting chemicals

Researchers reveal how cells respond to mechanical manipulation

Snack food with olestra speeds up removal of toxins in body

Researchers find that cancer gene require copper to promote tumor growth

Scientists design new system for molecular blood group typing

Researcher develops synthetic hydrogel that promotes natural clotting, heals surgical wounds

Research finding sheds more light on cancer development and metastasis

Researcher analyses effect of chromium supplementation on blood sugar

Study describes how overeating causes brown fat cells to "whiten"

Stem cells culled from bone marrow may prove beneficial in stroke recovery

Stressful upbringings can leave imprints on genes of African American children

Multiple genomic data could help improve studies of association between genes and disease

Study identifies two cell surface receptors that may be responsible for spread of lung cancer

Microphysiological systems in drug discovery

Considerations for taking ASO discovery programs into animal models

Neurofilament light as a translational biomarker

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