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Paper illuminates importance of PKM2 in cancer development and progression

Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which brain tumors thrive.

26 Nov 2012

CLCA1 molecule plays a special role in the mucus pathway

Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of death in these conditions - excess mucus production.

26 Nov 2012

Researchers discover LSD-1 enzyme as important target for treatment of Ewing sarcoma

Discovery of a new drug with high potential to treat Ewing sarcoma, an often deadly cancer of children and young adults, and the previously unknown mechanism behind it, come hand-in-hand in a new study by researchers from Huntsman Cancer Institute (HCI) at the University of Utah. The report appears in today's online issue of the journal Oncogene.

26 Nov 2012

Max Planck scientists identify unknown proteins of the herpesvirus

The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system, the scientists of the Max Planck Institute of Biochemistry in Martinsried near Munich and their collaboration partners at the University of California in San Francisco have shown that the genome of this virus contains much more information than previously assumed.

26 Nov 2012

Researchers discover molecular basis for potential cancer preventive effects of vitamin D

A team of researchers at McGill University have discovered a molecular basis for the potential cancer preventive effects of vitamin D. The team, led by McGill professors John White and David Goltzman, of the Faculty of Medicine's Department of Physiology, discovered that the active form of vitamin D acts by several mechanisms to inhibit both the production and function of the protein cMYC.

26 Nov 2012

New therapeutic technique to repair and rebuild muscle for degenerative muscle disorders

A study published today in BioMed Central's open access journal Skeletal Muscle reports of a new therapeutic technique to repair and rebuild muscle for sufferers of degenerative muscle disorders. The therapy brings together two existing techniques for muscle repair - cell transplantation and tissue engineering - specifically, mesoangioblast stem cells delivered via a hydrogel cell-carrier matrix.

26 Nov 2012

USPTO grants patent for galactomannan-based carbohydrate galectin inhibitor compounds

Galectin Therapeutics, the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, today announced that it has received a notice of allowance from the U.S. Patent and Trademark Office for a divisional patent of Patent Number 8,236,780 "Galactose-prolonged polysaccharides in a formulation for antifibrotic therapies".

26 Nov 2012

FDA grants Seattle Genetics orphan drug designation for ADCETRIS to treat mycosis fungoides

Seattle Genetics, Inc. announced today that ADCETRIS (brentuximab vedotin) has been granted orphan drug designation by the U.S. Food and Drug Administration (FDA) for the treatment of mycosis fungoides (MF). MF is the most common type of cutaneous T-cell lymphoma (CTCL).

26 Nov 2012

Alnylam advances Tuschl II patent estate through the USPTO

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that the United States Patent and Trademark Office has issued Notices of Allowance for three patent applications from the company's exclusively held Tuschl II patent estate.

26 Nov 2012

New therapeutic approach for preventing Alzheimer's disease

Pathological changes typical of Alzheimer's disease were significantly reduced in mice by blockade of an immune system transmitter. A research team from Charité - Universitätsmedizin Berlin and the University of Zurich has just published a new therapeutic approach in fighting Alzheimer's disease in the current issue of Nature Medicine. This approach promises potential in prevention, as well as in cases where the disease has already set in.

26 Nov 2012

Inovio's SynCon DNA vaccine effective at inducing CD8+ T cell responses specific to CMV

Inovio Pharmaceuticals, Inc. announced today that testing of multiple synthetic vaccine constructs for cytomegalovirus (CMV) induced robust T cells in mice, demonstrating the potential for a SynCon DNA vaccine to treat this virus that causes infant death and congenital abnormalities, is associated with cerebral palsy and brain tumors, and is the most common viral infection in organ transplant recipients. CMV is also associated with numerous inflammatory diseases and cancers, and is implicated in hypertension, a major risk factor for cardiovascular diseases.

26 Nov 2012

Negative messages not having an impact in people with addictive behaviors

What types of public messages will most likely deter drug and alcohol abuse or dissuade people from engaging in risky behavior? Negatively framed messages may not be an effective way to reach those most in need of persuasion, suggests a new study in Psychology of Addictive Behaviors by researchers from Indiana University and Wayne State University.

26 Nov 2012

Cancer-killing viruses found safe but less effective than expected

Doctors now use cancer-killing viruses to treat some patients with lethal, fast-growing brain tumors. Clinical trials show that these therapeutic viruses are safe but less effective than expected.

26 Nov 2012

Researchers reveal molecular mechanisms that lead to basal cell carcinoma initiation

Advanced online publication in Nature Cell Biology: Researchers at the Université libre de Bruxelles, uncover the molecular mechanisms leading to basal cell carcinoma initiation.

26 Nov 2012

Stroke patients may perform better in clinical tests when offered a reward

Stroke patients who have difficulty paying attention to part of their visual field may perform better when offered a reward, a study by Imperial College London and Brunel University researchers has found.

26 Nov 2012

Women more likely to have gray matter atrophy prior to Alzheimer's diagnosis than men

All patients with Alzheimer's disease (AD) lose brain cells, which leads to a shrinking, or atrophy, of the brain. But the pattern of gray matter loss is significantly different in men and women, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

26 Nov 2012

$Study identifies fractional anisotropy as predictor of brain damage after TBI$

Study identifies fractional anisotropy as predictor of brain damage after TBI

Using a special magnetic resonance imaging (MRI) technique to image patients with mild traumatic brain injury (MTBI), researchers have identified a biomarker that may predict which patients will do well over the long term, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

26 Nov 2012

People with Parkinson's benefit from exercise programs on stationary bicycles

People with Parkinson's disease benefit from exercise programs on stationary bicycles, with the greatest effect for those who pedal faster, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

26 Nov 2012

Active lifestyle helps preserve brain structure and could reduce burden of dementia, Alzheimer's

An active lifestyle helps preserve gray matter in the brains of older adults and could reduce the burden of dementia and Alzheimer's disease (AD), according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

26 Nov 2012

Alcohol exposure during fetal development alters brain structure and metabolism in children

Children exposed to alcohol during fetal development exhibit changes in brain structure and metabolism that are visible using various imaging techniques, according to a new study being presented today at the annual meeting of the Radiological Society of North America (RSNA).

26 Nov 2012

Medical Science News

Paper illuminates importance of PKM2 in cancer development and progression

CLCA1 molecule plays a special role in the mucus pathway

Researchers discover LSD-1 enzyme as important target for treatment of Ewing sarcoma

Max Planck scientists identify unknown proteins of the herpesvirus

Researchers discover molecular basis for potential cancer preventive effects of vitamin D

New therapeutic technique to repair and rebuild muscle for degenerative muscle disorders

USPTO grants patent for galactomannan-based carbohydrate galectin inhibitor compounds

FDA grants Seattle Genetics orphan drug designation for ADCETRIS to treat mycosis fungoides

Alnylam advances Tuschl II patent estate through the USPTO

New therapeutic approach for preventing Alzheimer's disease

Inovio's SynCon DNA vaccine effective at inducing CD8+ T cell responses specific to CMV

Negative messages not having an impact in people with addictive behaviors

Cancer-killing viruses found safe but less effective than expected

Researchers reveal molecular mechanisms that lead to basal cell carcinoma initiation

Stroke patients may perform better in clinical tests when offered a reward

Women more likely to have gray matter atrophy prior to Alzheimer's diagnosis than men

Study identifies fractional anisotropy as predictor of brain damage after TBI

People with Parkinson's benefit from exercise programs on stationary bicycles

Active lifestyle helps preserve brain structure and could reduce burden of dementia, Alzheimer's

Alcohol exposure during fetal development alters brain structure and metabolism in children

The CAR T Veteran: A Journey of Resilience, Remission, and Advocacy

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

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