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Study investigates how glucose metabolism affects biochemical signals in cancer cells

Compared to normal cells, cancer cells have a prodigious appetite for glucose, the result of a shift in cell metabolism known as aerobic glycolysis or the "Warburg effect." Researchers focusing on this effect as a possible target for cancer therapies have examined how biochemical signals present in cancer cells regulate the altered metabolic state.

27 Jun 2012

Prenatal exposure to BPA appears to program uterine estrogen responsiveness in adulthood

Prenatal exposure to bisphenol A, or BPA, a chemical found in many common plastic household items, can cause numerous genes in the uterus to respond differently to estrogen in adulthood, according to a study using a mouse model. The results will be presented Tuesday at The Endocrine Society's 94th Annual Meeting in Houston.

27 Jun 2012

Seahorse Bioscience launches XF Palmitate-BSA FAO Reagent for FAO assays

Seahorse Bioscience, the world leader in manufacturing instrumentation and assay kits for measuring cellular metabolism, has announced the launch of its newest product, the XF Palmitate-BSA FAO Reagent, eliminating the need for radioactivity in fatty acid oxidation (FAO) assays.

27 Jun 2012

Study shows how brain insulin resistance contributes to neurodegeneration in AD

Rhode Island Hospital researcher Suzanne de la Monte, M.D., has found a link between brain insulin resistance (diabetes) and two other key mediators of neuronal injury that help Alzheimer's disease (AD) to propagate.

27 Jun 2012

Sunshine Biopharma completes Adva-27a cytotoxicity study on multidrug-resistant lung cancer

Sunshine Biopharma Inc., a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed a cytotoxicity study of its lead compound, Adva-27a, in H69AR, a Multidrug Resistant Small Cell Lung Cancer cell line. Cytotoxicity studies measure the ability of a drug to destroy cancer cells in vitro.

27 Jun 2012

Study details how Parkinson's disease spreads through the brain

Van Andel Institute announces that researchers at Lund University in Sweden have published a study detailing how Parkinson's disease spreads through the brain. Experiments in rat models uncover a process previously used to explain mad cow disease, in which misfolded proteins travel from sick to healthy cells.

27 Jun 2012

Research reveals benefits of exercise in combating Alzheimer's disease

In a recent Journal of Biological Chemistry "Paper of the Week," research led by Ayae Kinoshita at the Kyoto University Graduate School of Medicine in Japan reveals the benefits of exercise in combating Alzheimer's disease.

27 Jun 2012

DHA and curcumin preserve walking ability in rats with spinal-cord injury

UCLA researchers discovered that a diet enriched with a popular omega-3 fatty acid and an ingredient of curry spice preserved walking ability in rats with spinal-cord injury. Published June 26 in the Journal of Neurosurgery: Spine, the findings suggest that these dietary supplements help repair nerve cells and maintain neurological function after degenerative damage to the neck.

27 Jun 2012

Caltech researchers develop technique to focus light inside biological tissue

Imagine if doctors could perform surgery without ever having to cut through your skin. Or if they could diagnose cancer by seeing tumors inside the body with a procedure that is as simple as an ultrasound.

27 Jun 2012

RXi Pharmaceuticals initiates RXI-109 Phase 1 trial to reduce surgical scars

RXi Pharmaceuticals Corporation today announced that it successfully initiated its first ever clinical study with an RNAi compound, RXI-109, using their proprietary self-delivering RNAi technology.

27 Jun 2012

Maternal factors associated with fetal growth restriction

A Japanese study has found that maternal rather than fetal factors are associated with fetal growth restriction. A comparison of maternal and fetal angiotensin-converting enzyme genotypes with the size of babies at birth found evidence of this connection.

27 Jun 2012

HemoGenix receives first Master File Number from FDA CBER for HALO-96 PQR

HemoGenix announced today that FDA CBER has given HemoGenix its first Master File Number for an in vitro blood stem cell potency, quality and release assay (HALO-96 PQR) for cellular therapy products used for stem cell transplantation purposes. HALO-96 PQR is the first commercially available stem cell potency assay for cellular therapy products.

27 Jun 2012

Greater awareness of MH and consequences of ryanodine receptor gene mutations

From the MHAUS President's Blog by MHAUS President, Henry Rosenberg, MD. A few months ago, I received a call from the MH Hotline who connected me to an anesthesiologist and OR team who were desperately trying to manage a Malignant Hyperthermia crisis.

26 Jun 2012

Marker to identify patients who have difficulties in maintaining body weight

A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study. The results will be presented Sunday at The Endocrine Society's 94th Annual Meeting in Houston.

26 Jun 2012

Ghrelin increases incentive for humans to eat high-calorie foods

A new study suggests that the appetite-inducing hormone ghrelin increases the incentive for humans to eat high-calorie foods, even on a full stomach. The results will be reported Sunday at The Endocrine Society's 94th Annual Meeting in Houston.

26 Jun 2012

New tissue-culture study: Fungicide can induce insulin resistance

A fungicide used on farm crops can induce insulin resistance, a new tissue-culture study finds, providing another piece of evidence linking environmental pollutants to diabetes. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

26 Jun 2012

Reproductive hormone helps regulate food intake, energy metabolism without adverse effects

A reproductive hormone helps regulate food intake and energy metabolism without causing adverse effects, a new animal study finds. The results will be presented Monday at The Endocrine Society's 94th Annual Meeting in Houston.

26 Jun 2012

SmartTots announces recipients of inaugural round of research grants

SmartTots announced Robert Block, PhD and Caleb Ing, MD as the recipients of its inaugural round of research grants today. The research grants are intended to support investigations into the existence of a clinical signal suggesting poor neurocognitive outcomes as the result of early exposure to anesthesia. Drs. Block and Ing will be conducting separate studies both centered around determining the effects of anesthetics on early brain development. Both recipients will receive $100,000 to fund their studies.

26 Jun 2012

Nanoparticles that can slip through mucus barriers shown to protect against herpes infections

Johns Hopkins researchers say they have demonstrated, for the first time in animals, that nanoparticles can slip through mucus to deliver drugs directly to tissue surfaces in need of protection. The researchers used these mucus-penetrating particles (MPPs) to protect against vaginal herpes infections in mice and the goal is to create similar MPPs to deliver drugs that protect humans against sexually transmitted diseases or even treat cancer.

26 Jun 2012

Having antibodies for cutaneous HPV and sun exposure can act synergistically in BCC, SCC

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and the German Cancer Research Center in Heidelberg have found that having antibodies for cutaneous types of human papillomavirus (HPV), coupled with sun exposure (ultraviolet radiation) or poor tanning ability, can act "synergistically" in the development of non-melanoma skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

26 Jun 2012

Medical Science News

Study investigates how glucose metabolism affects biochemical signals in cancer cells

Prenatal exposure to BPA appears to program uterine estrogen responsiveness in adulthood

Seahorse Bioscience launches XF Palmitate-BSA FAO Reagent for FAO assays

Study shows how brain insulin resistance contributes to neurodegeneration in AD

Sunshine Biopharma completes Adva-27a cytotoxicity study on multidrug-resistant lung cancer

Study details how Parkinson's disease spreads through the brain

Research reveals benefits of exercise in combating Alzheimer's disease

DHA and curcumin preserve walking ability in rats with spinal-cord injury

Caltech researchers develop technique to focus light inside biological tissue

RXi Pharmaceuticals initiates RXI-109 Phase 1 trial to reduce surgical scars

Maternal factors associated with fetal growth restriction

HemoGenix receives first Master File Number from FDA CBER for HALO-96 PQR

Greater awareness of MH and consequences of ryanodine receptor gene mutations

Marker to identify patients who have difficulties in maintaining body weight

Ghrelin increases incentive for humans to eat high-calorie foods

New tissue-culture study: Fungicide can induce insulin resistance

Reproductive hormone helps regulate food intake, energy metabolism without adverse effects

SmartTots announces recipients of inaugural round of research grants

Nanoparticles that can slip through mucus barriers shown to protect against herpes infections

Having antibodies for cutaneous HPV and sun exposure can act synergistically in BCC, SCC

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

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