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Study aims to develop noninvasive method to analyze interstitial cystitis

A pilot study led by University of Kentucky researchers shows that the gene expression analysis of urine sediment could provide a noninvasive way to analyze interstitial cystitis in some patients.

24 Feb 2012

Bath salts mimic effects of two powerful narcotics

The street drug commonly referred to as "bath salts" is one of a growing list of synthetic and unevenly regulated narcotics that are found across the United States and on the Internet. New research on this potent drug paints an alarming picture, revealing that bath salts pack a powerful double punch, producing combined effects similar to both methamphetamine (METH) and cocaine.

24 Feb 2012

Nicotine can contribute to atherosclerosis

Cigarette smoke has long been considered the main risk factor for heart disease. But new research from Brown University in Providence, R.I., shows that nicotine itself, a component of cigarette smoke, can contribute to the disease process by changing cell structure in a way that promotes migration and invasion of the smooth muscle cells that line blood vessels.

24 Feb 2012

UM scientists discover high concentrations of BMAA in shark fins

Sharks are among the most threatened of marine species worldwide due to unsustainable overfishing. Sharks are primarily killed for their fins alone, to fuel the growing demand for shark fin soup, which is an Asia delicacy. A new study by University of Miami (UM) scientists in the journal Marine Drugs has discovered high concentrations of BMAA in shark fins, a neurotoxin linked to neurodegenerative diseases in humans including Alzheimer's and Lou Gehrig Disease.

24 Feb 2012

UBC develops algorithm to predict how and when proteins misfold

Several neurodegenerative diseases - including Alzheimer's and ALS (Lou Gehrig's disease) - are caused when the body's own proteins fold incorrectly, recruit and convert healthy proteins to the misfolded form, and aggregate in large clumps that gum up the works of the nervous system. "For Star Trek fans, this is like the Borg, a fictional race of cyborgs that abduct and assimilate humans and other species," says Steven Plotkin, a biophysicist at the University of British Columbia in Vancouver who studies the process of protein misfolding.

24 Feb 2012

Unfolded end of Colicin N protein can kill antibiotic-resistant microbes

When bacteria wage a turf war, some of the combatants have an extra weapon. Certain strains of the bacteria E. coli produce proteins that kill competing E. coli and other like microbes, and researchers from Newcastle University in England have recently discovered something surprising about one of these lethal proteins: even after the toxic folded portion of the protein is removed, the unfolded end is still deadly.

24 Feb 2012

New experiments may provide insights into possible modes of heart damage from alcohol

Beyond the personal tragedy of chronic alcoholism there is heartbreak in the biological sense, too. Scientists know severe alcoholism stresses the heart and that mitochondria, the cellular energy factories, are especially vulnerable to dysfunction. But they don't know the precise mechanism.

24 Feb 2012

Scientists identify specific pathways behind breast cell's transformation into cancer

Although it's widely accepted that inflammation is a critical underlying factor in a range of diseases, including the progression of cancer, little is known about its role when normal cells become tumor cells. Now, scientists from the Florida campus of The Scripps Research Institute have shed new light on exactly how the activation of a pair of inflammatory signaling pathways leads to the transformation of normal breast cells to cancer cells.

24 Feb 2012

UA researchers identify the likely culprit of epilepsy

Only 10 years ago, deciphering the genetic information from one individual in a matter of weeks to find a certain disease-causing genetic mutation would have been written off as science fiction. It was the time of the Human Genome Project, and it had taken armies of sequencing robots working around the clock for almost a decade to unravel the complete sequence of the human genetic code - referred to as the genome - by churning out the DNA alphabet letter by letter.

24 Feb 2012

Scientists decode two new blood types

You probably know your blood type: A, B, AB or O. You may even know if you're Rhesus positive or negative. But how about the Langereis blood type? Or the Junior blood type? Positive or negative? Most people have never even heard of these.

24 Feb 2012

Cigarette smoke exposure results in allograft rejection

A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments.

24 Feb 2012

Scientists identify promising strategy for HIV vaccine design

HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate. Physical scientists and clinical virologists from the Massachusetts Institute of Technology (MIT) and the Ragon Institute in Cambridge, Mass., have identified a promising strategy for vaccine design using a mathematical technique that has also been used in problems related to quantum physics, as well as in analyses of stock market price fluctuations and studies of enzyme sequences.

24 Feb 2012

Scientists identify specific mechanisms by which vitamin D inhibits inflammation

Researchers at National Jewish Health have discovered specific molecular and signaling events by which vitamin D inhibits inflammation. In their experiments, they showed that low levels of Vitamin D, comparable to levels found in millions of people, failed to inhibit the inflammatory cascade, while levels considered adequate did inhibit inflammatory signaling.

24 Feb 2012

Hibernation may provide insight into arrhythmia therapies

How much calcium could a hibernating woodchuck's heart cells sequester, if a hibernating woodchuck's heart cells could sequester calcium? More than enough, it turns out, to protect the animals from cardiac arrhythmias - abnormal heart rhythms such as ventricular tachycardia and ventricular fibrillation that can lead to sudden cardiac death - according to a new study of the hibernating animals that may provide insight into arrhythmia therapies.

23 Feb 2012

FSU receives NIH grant to better understand and diagnose dyslexia

If you can read this sentence with ease, consider yourself fortunate: Millions of Americans with dyslexia cannot. In the hope of improving the lives of those struggling readers, a team of experts at Florida State University is working to better understand and diagnose dyslexia and other learning disabilities with a new, $8.5 million grant from the National Institutes of Health.

23 Feb 2012

Gonadal dysgenesis may also increase risk of gonadal tumors

Pediatric and Developmental Pathology - Gonadal dysgenesis—defective development of the ovaries or testes— may also bring with it an increased risk of gonadal tumors. A recent discovery at the histologic level could help identify cells at risk of conversion into a tumor.

23 Feb 2012

'Good-times' pumps warn cells of approaching starvation

Sugar, cholesterol, phosphates, zinc - a healthy body is amazingly good at keeping such vital nutrients at appropriate levels within its cells. From an engineering point of view, one all-purpose model of pump on the surface of a cell should suffice to keep these levels constant: When the concentration of a nutrient, say, sugar, drops inside the cell, the pump mechanism could simply go into higher gear until the sugar levels are back to normal.

23 Feb 2012

Dual regulation by similar proteins may degenerate in heart failure

Sudden cardiac death is a risk for patients with heart failure because the calcium inside their heart cells is not properly controlled and this can lead to an irregular heartbeat. New findings published in PLoS ONE, which reveal mechanisms that underlie this life-threatening risk, provide new possibilities for fighting it.

23 Feb 2012

New model to evaluate probiotic survival in the gut

Functional foods containing bacteria with beneficial health effects, or probiotics, have long been consumed in Northern Europe and are becoming increasingly popular elsewhere. To be of benefit, however, the bacteria have to survive in the very hostile environment of the digestive tract.

23 Feb 2012

Unknown facets of biological mechanism that immune cells use for creating free radicals

Sometimes our immune defence attacks our own cells. When this happens in the brain we see neurodegenerative diseases such as dementia, Alzheimer's and Parkinson's disease. But if the the immune defence is inhibited, the results could be disastrous.

23 Feb 2012