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Nanoparticles could help increase retention of osteoarthritis drugs in knee cavity

A novel study demonstrates that using nanoparticles to deliver osteoarthritis drugs to the knee joint could help increase the retention of the drug in the knee cavity, and therefore reduce the frequency of injections patients must receive.

27 Oct 2011

E. coli asparaginase linked to relapses in ALL patients with special form of ATF5 gene

One of the causes of resistance to cancer treatment in children is now beginning to be elucidated. Acute lymphoblastic leukemia patients with a particular form of the ATF5 gene are at higher risk of having a relapse when treated with E. coli asparaginase, a key chemotherapy drug for this type of leukemia.

27 Oct 2011

Scripps researcher receives U-M's Eric J. Topol Professorship in Cardiovascular Medicine

The University of Michigan Medical School today announced the establishment of the Eric J. Topol Professorship in Cardiovascular Medicine. A world-renowned cardiologist, Dr. Topol is currently chief academic officer at Scripps Health and a senior cardiologist practitioner at Scripps Clinic.

27 Oct 2011

New potential leukemia therapy targets and kills cancer cells

A new potential leukemia therapy targets only cancer cells, while leaving healthy cells alone. Many current chemotherapy treatments affect cancer cells and healthy cells, causing significant side effects, such as fatigue, hair loss, nausea, anxiety and depression.

27 Oct 2011

BROCA test identifies 12 gene mutations linked to ovarian and related cancers

More patients with ovarian carcinoma carry cancer-predisposing mutations, and in more genes, than previously thought.

27 Oct 2011

Children have fewer components that strengthen their immune defense than adults do

Children have fewer components that strengthen their immune defense than adults do. This is shown in a mapping of children's saliva that was carried out at Malmö University in Sweden. The study may have found an explanation for children's inability to fend off infections.

27 Oct 2011

Blood biomarker panel can predict survival in IPF patients

A panel of blood proteins can predict which patients with the progressive lung disease idiopathic pulmonary fibrosis (IPF) are likely to live at least five years or to die within two years, say researchers at the University of Pittsburgh School of Medicine and Centocor R&D.

27 Oct 2011

Study: pGJA-P/VAX vaccine shows promise against dental caries

In a report on a preclinical investigation titled "Flagellin Enhances Saliva IgA Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.

27 Oct 2011

Surgeons freeze organoid units and regenerate TESI for short bowel syndrome

Surgeons at Children's Hospital Los Angeles have conducted a study that could put regenerative tissue treatment for short bowel syndrome one step closer to the bedside. The researchers were able to successfully isolate and store organoid units and later generate tissue-engineered small intestine (TESI) in a mouse model. The groundbreaking results were presented at the 2011 Annual Clinical Congress of the American College of Surgeons.

27 Oct 2011

Insulin resistance paradox

Obesity and insulin resistance are almost inevitably associated with increases in lipid accumulation in the liver, a serious disease that can deteriorate to hepatitis and liver failure. A real paradox in understanding insulin resistance is figuring out why insulin-resistant livers make more fat. Insulin resistance occurs when the body does a poor job of lowering blood sugars.

27 Oct 2011

New genomic approach can trace food-borne bacteria with unprecedented accuracy

With salmonella-tainted ground turkey sickening more than 100 people and listeria-contaminated cantaloupes killing 15 this year, the ability to detect outbreaks of food-borne illness and determine their sources has become a top public health priority.

27 Oct 2011

Super broccoli on the shelves to protect from heart disease

British scientists unveiled a new breed of broccoli that experts say packs heavy on nutritional values. The new broccoli was specially grown to contain two to three times the normal amount of glucoraphanin, a nutrient believed to help ward off heart disease. Glucoraphanin breaks fat down in the body, preventing it from clogging the arteries.

27 Oct 2011

Study reveals a possible way to reduce false alarms during early breast cancer screening

Early detection of breast cancer saves thousands of lives each year. But screening for breast cancer also produces false alarms, which can cause undue stress and costly medical bills. Now, a recent study using patient blood reveals a possible way to reduce the number of false alarms that arise during early screening. Researchers found a panel of proteins shed by breast cancer that are easily detected and can distinguish between real cancer and benign lumps.

27 Oct 2011

VitaYeast project to curb global malnutrition

Any way you slice it, bread that contains critical nutrients could help combat severe malnutrition in impoverished regions. That is the goal of a group of Johns Hopkins University undergraduate students who are using synthetic biology to enhance common yeast so that it yields beta carotene, the orange substance that gives carrots their color. When it's eaten, beta-carotene turns into vitamin A.

27 Oct 2011

Breast milk component induces expression of P-glycoprotein

Researchers at Children's Hospital Los Angeles have found that a component of breast milk induces expression of P-glycoprotein (Pgp), a protein that is protective against necrotizing enterocolitis (NEC)--a complex, lethal disease that affects up to 7 percent of babies admitted to the NICU.

27 Oct 2011

Study provides details on genetics behind many metabolic diseases

In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes. The results from this study could lead to highly targeted, individualized therapies.

27 Oct 2011

Scientists discover gene variants that contribute to early stent thrombosis

In a first-of-its-kind study, researchers from Mount Sinai School of Medicine have discovered several gene variants contributing to early stent thrombosis (ST), a devastating and often deadly complication after coronary stent implantation in people with coronary artery disease.

27 Oct 2011

BGI, UC Davis partner to create new sequencing facility in Sacramento

The University of California, Davis, and BGI, the world's largest genomic institute, based in China, have signed a historic agreement that will change the landscape of genomic sciences in California and the Western states, and foster critical breakthroughs in the areas of food security and human, animal and environmental health.

27 Oct 2011

Simple blood test could quantify a smoker's lung toxicity and danger of heart disease

A simple blood test could someday quantify a smoker's lung toxicity and danger of heart disease, researchers at UT Southwestern Medical Center have found.

27 Oct 2011

DNA synbodies, a new class of affinity reagents, gets major NIH boost

An ongoing Arizona State University effort to develop a revolutionary class of reagents that holds great promise for the future of medicine has received a major boost with a three-year, $4 million award from the National Institutes of Health.

24 Oct 2011