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New transgenic mouse could predict toxicity of targeted cancer drugs

Only one in twenty cancer drugs makes its way from the laboratory to become an approved pharmaceutical product. The majority of new agents are only shown to be unsuitable in the later phases of clinical development which would explain the exorbitantly high development costs of 500 to 600 million euros per new cancer drug.

20 Jul 2011

Nuclear Factor I/B appears to drive progression of small cell lung cancer

A major challenge for cancer biologists is figuring out which among the hundreds of genetic mutations found in a cancer cell are most important for driving the cancer's spread.

20 Jul 2011

Falls, balance problems linked to early stages of Alzheimer's

Falls and balance problems may be early indicators of Alzheimer's disease, researchers at Washington University School of Medicine in St. Louis reported July 17, 2011, at the Alzheimer's Association International Conference on Alzheimer's Disease in Paris.

20 Jul 2011

Gel Company, Biomerix partner to market and distribute 3D Scaffold

Biomerix Corporation and Gel Company today announced a strategic distribution agreement for the Biomerix 3D Scaffold, a novel three-dimensional tissue scaffold. Under the agreement, Gel Company will market and distribute the Biomerix 3D Scaffold to researchers in the life science community across the United States.

20 Jul 2011

Altogen Labs introduces pyrosequencing services for hospitals, research institutions

Altogen Labs, a biology contract research organization and provider of pre-clinical research services, announced its launch of a pyrosequencing service today.

20 Jul 2011

Two key genes may help prevent childhood leukemia

Researchers at The University of Western Ontario have identified genes that may be important for preventing childhood leukemia. Acute lymphoblastic leukemia (ALL) is a cancer of the blood that occurs primarily in young children.

19 Jul 2011

Sigma introduces CompoZr Targeted Integration Kit – mRosa26

Sigma Life Science, the innovative biological products and services research business of Sigma-Aldrich Corporation today announced the launch of CompoZr Targeted Integration Kit – mRosa26, which can precisely and rapidly integrate transgenes into the mouse genome at the Rosa26 safe harbor locus.

19 Jul 2011

New nanotechnology-based cancer treatment might improve chemotherapy

Researchers of the University of Granada and Edinburgh have developed a new therapy for cancer based on nanotechnology that might improve significantly chemotherapy, as it has not cause side effects.

19 Jul 2011

UNC receives $3M federal grant for AIDS research

Scientists at the University of North Carolina at Chapel Hill schools of medicine and pharmacy have been awarded a $3 million federal grant to develop and test a new generation of treatments aimed at preventing sexual transmission of HIV to uninfected individuals.

19 Jul 2011

First neurobiological evidence for theory of episodic memory

Almost everyone has experienced one memory triggering another, but explanations for that phenomenon have proved elusive. Now, University of Pennsylvania researchers have provided the first neurobiological evidence that memories formed in the same context become linked, the foundation of the theory of episodic memory.

19 Jul 2011

Food4Me project to investigate potential of personalised nutrition

When the human genome sequence was launched in 2000, it introduced the possibility of personalisation in health care. Such personalisation can be applied to nutrition, a key health determinant, to create a diet tailored specifically for an individual, according to their individual physical and genetic make-up. Food4Me is a new, EU (FP7) funded project investigating the potential of this personalised nutrition.

19 Jul 2011

Scientists discover cholesterol moves far slower within and between cells

Neutrons have shown the movement of cholesterol between and within cells takes far longer than previously thought. Findings could impact the treatment of a range of diseases linked to abnormal rates of cholesterol transfer.

19 Jul 2011

Scientists identify new inherited form of Parkinson's disease

Scientists at the Helmholtz Zentrum München and the Technische Universität München working in cooperation with the Medical University of Vienna have identified a mutation associated with a inherited form of late-onset Parkinson's disease.

19 Jul 2011

Researchers identify potential therapeutic target for ER-negative breast cancer

Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in the serine biosynthesis pathway that is essential in estrogen receptor (ER)-negative breast cancer—a notoriously difficult disease to treat associated with low five-year survival rates.

19 Jul 2011

Scientists find way to make copper-catalyzed click chemistry biocompatible

Biomolecular imaging can reveal a great deal of information about the inner workings of cells and one of the most attractive targets for imaging are glycans - sugars that are ubiquitous to living organisms and abundant on cell surfaces. Imaging a glycan requires that it be tagged or labeled. One of the best techniques for doing this is a technique called click chemistry.

19 Jul 2011

International Journal of Cancer publishes Bionovo's Bezielle research

Bionovo, Inc., a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, today announced the publication of a study of the metabolic effects of its drug candidate, Bezielle, on cancer cells in the International Journal of Cancer.

19 Jul 2011

Preliminary data from Amorfix human diagnostic test for Alzheimer's presented at ICAD

Amorfix Life Sciences, a product development company focused on diagnostics and therapeutics for misfolded protein diseases, presented a paper on Sunday July 17th, 2011 at the International Conference on Alzheimer's disease in Paris, France.

19 Jul 2011

Novel approach for preventing HIV infection

Scientists at Osel Inc. and the National Cancer Institute (NCI) have developed a new way to prevent HIV infection by genetically enhancing the ability of naturally occurring vaginal bacteria to block viral transmission.

19 Jul 2011

Single TBI may accelerate Alzheimer's disease-like neurodegeneration

Years after a single traumatic brain injury (TBI), survivors still show changes in their brains. In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania suggest that Alzheimer's disease-like neurodegeneration may be initiated or accelerated following a single traumatic brain injury, even in young adults.

19 Jul 2011

Researchers identify gene linked to muscle endurance

Researchers at the Perelman School of Medicine at the University of Pennsylvania have identified a gene for endurance, or more precisely, a negative regulator of it.

19 Jul 2011