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Scientists generate beating heart cells from skin cells of young patients with severe genetic heart defect

Using skin cells from young patients who have a severe genetic heart defect, Stanford University School of Medicine scientists have generated beating heart cells that carry the same genetic mutation. The newly created human heart cells - cardiomyocytes - allowed the researchers for the first time to examine and characterize the disorder at the cellular level.

10 Feb 2011

Scientists discover KCNH2 gene mutation in patients with long QT syndrome

Researchers from the Hospital Virgen de las Nieves of the University of Granada have identified the most frequent mutations in the gene KCNH2 in patients with long QT syndrome.

10 Feb 2011

L-methylfolate in combination with antidepressant drug helps major depressive disorder patients

Data published in the January issue of Innovations in Clinical Neuroscience, www.psychiatrymmc.com, suggest when L-methylfolate, a medical food available commercially as Deplin®, and by prescription, is used for dietary management of depression in combination with an antidepressant drug at the start of depression therapy, it results in significantly more patients experiencing major improvement and more rapid improvement than antidepressant monotherapy alone.

10 Feb 2011

Mg significantly reduces neonatal brain injury linked with maternal inflammation, infection

In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting -, in San Francisco, researchers will present findings that showed that in rats, the use of magnesium sulfate significantly reduced the neonatal brain injury associated with maternal inflammation or maternal infection.

10 Feb 2011

Liquidia to explore PRINT particle technology with PATH Malaria Vaccine Initiative

Liquidia Technologies today announced a collaboration with the PATH Malaria Vaccine Initiative (MVI) to explore the use of the company's PRINT® particle technology to design next generation malaria vaccines. PRINT technology offers unprecedented control of particle size, shape and chemistry in a highly consistent and scalable manufacturing process, and will be used to deliver a protein in combination with immune stimulating molecules.

10 Feb 2011

Protein cross-linking enzymes in foods can affect physiological characteristics

Protein modification via enzymatic cross-linking is an attractive way for altering food structure so as to create products with increased quality and nutritional value. These modifications are expected to affect not only the structure and physico-chemical properties of proteins but also their physiological characteristics, such as digestibility in the GI-tract and allergenicity.

10 Feb 2011

FDA grants Neuralstem orphan drug designation for treatment of ALS with spinal cord stem cells

Neuralstem, Inc. announced that the U.S. Food and Drug Administration's Office of Orphan Products Development has granted it orphan drug designation for the treatment of Amyotrophic Lateral Sclerosis (ALS) with its human spinal cord derived neural stem cells (NSI-566RSC), currently in a Phase I safety study to evaluate the safety of the product and the surgical route of administration in a wide range of ALS patients.

10 Feb 2011

Seaweed microsponges may help diagnose many diseases quickly, at far lower cost

Microsponges derived from seaweed may help diagnose heart disease, cancers, HIV and other diseases quickly and at far lower cost than current clinical methods. The microsponges are an essential component of Rice University's Programmable Bio-Nano-Chip (PBNC) and the focus of a new paper in the journal Small.

9 Feb 2011

New study: Testosterone administration leads to significant reduction in mind reading

A new study from Utrecht and Cambridge Universities has for the first time found that an administration of testosterone under the tongue in volunteers negatively affects a person's ability to 'mind read', an indication of empathy. The findings are published this week in the journal Proceedings of the National Academy of Sciences.

9 Feb 2011

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. The results, appearing in the latest issue of the Journal of Cell Biology, promise to open the door to new possibilities for drug development.

9 Feb 2011

Rapid detection of transiently folded single-molecule structures from 'intrinsically disordered proteins'

A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein. The insights could help scientists to better understand the mechanism of plaque formation in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

9 Feb 2011

Research findings highlight potential for noninvasive MSC delivery to treat Parkinson disease

Successful intranasal delivery of stem cells to the brains of rats with Parkinson disease yielded significant improvement in motor function and reversed the dopamine deficiency characteristic of the disease.

9 Feb 2011

Topical cream used to treat skin diseases activates two distinct neuronal signaling pathways

Scratching deep beneath the surface, a team of researchers from the University of California, San Diego School of Medicine and three South Korean institutions have identified two distinct neuronal signaling pathways activated by a topical cream used to treat a variety of skin diseases. One pathway produces the therapeutic benefit; the other induces severe itching as a side effect.

9 Feb 2011

Circassia acquires global rights to novel topical therapeutic for psoriasis and atopic dermatitis

Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced that it has acquired the worldwide development and commercialization rights to the novel topical therapeutic for psoriasis and atopic dermatitis, PAP-1. Circassia acquired the rights to the proprietary molecule from Airmid Inc, for an undisclosed upfront sum plus milestone payments and royalties on future product sales.

9 Feb 2011

Men with high levels of CCP genes more likely to have fatal form of prostate cancer

A genetic pattern could predict how aggressive prostate cancer is before treatment, and whether the disease will come back in men who have already been treated, according to research published1 in the Lancet Oncology.

9 Feb 2011

Two new studies report GOT may improve health outcomes of stroke patients

Much of the devastation of stroke and head trauma is due to damage caused the overproduction of a substance in the brain called glutamate. Preventing this damage has been impossible, until now, as many drugs don't cross the so-called blood-brain barrier, and those that do often don't work as intended. But a method originally devised at the Weizmann Institute of Science may, in the future, offer a way to avert such glutamate-induced harm.

9 Feb 2011

New research provides evidence that cerebellum can also store memories for mental skills

Movements become skilled and automatic with practise, so tasks like riding a bicycle can be performed without much attention or mental effort. New research by scientists at Royal Holloway, University of London provides evidence that the cerebellum, a part of the brain used to store memories for skilled movements, could also store memories important for mental skills - such as the rules used to interpret traffic light signals.

9 Feb 2011

Drugs against protective action of bacteria's antitoxin molecules

Bacteria often attack with toxins designed to hijack or even kill host cells. To avoid self-destruction, bacteria have ways of protecting themselves from their own toxins.

9 Feb 2011

Specific gene variation linked to late-onset Alzheimer's

A new study from the Centre for Addiction and Mental Health (CAMH) has found evidence suggesting that a variation of a specific gene may play a role in late-onset Alzheimer's, the disease which accounts for over 90% of Alzheimer's cases. This innovative study has combined genetics and brain imaging to determine who may be at risk for developing late-onset Alzheimer's disease long before symptoms appear.

9 Feb 2011

UW research receives Keck Foundation grant to restore lost brain function using neurochips

Tiny, implantable computers that would restore brain function lost to disease or injury is the goal of University of Washington research recently funded by a $1 million, three-year grant from the W.M. Keck Foundation.

9 Feb 2011

Medical Science News

Scientists generate beating heart cells from skin cells of young patients with severe genetic heart defect

Scientists discover KCNH2 gene mutation in patients with long QT syndrome

L-methylfolate in combination with antidepressant drug helps major depressive disorder patients

Mg significantly reduces neonatal brain injury linked with maternal inflammation, infection

Liquidia to explore PRINT particle technology with PATH Malaria Vaccine Initiative

Protein cross-linking enzymes in foods can affect physiological characteristics

FDA grants Neuralstem orphan drug designation for treatment of ALS with spinal cord stem cells

Seaweed microsponges may help diagnose many diseases quickly, at far lower cost

New study: Testosterone administration leads to significant reduction in mind reading

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Rapid detection of transiently folded single-molecule structures from 'intrinsically disordered proteins'

Research findings highlight potential for noninvasive MSC delivery to treat Parkinson disease

Topical cream used to treat skin diseases activates two distinct neuronal signaling pathways

Circassia acquires global rights to novel topical therapeutic for psoriasis and atopic dermatitis

Men with high levels of CCP genes more likely to have fatal form of prostate cancer

Two new studies report GOT may improve health outcomes of stroke patients

New research provides evidence that cerebellum can also store memories for mental skills

Drugs against protective action of bacteria's antitoxin molecules

Specific gene variation linked to late-onset Alzheimer's

UW research receives Keck Foundation grant to restore lost brain function using neurochips

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications

Precision in every drop: Inside Hamilton’s syringe technology

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