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New approach reduces JAK2 activity by pharmacologically targeting HSP90 protein

Myeloproliferative neoplasms (MPN) comprise a family of blood cancers characterized by clonal expansion of a single blood cell type. Untreated, these cancers can progress to bone marrow failure and acute myeloid leukemia. Several groups have identified activating mutations in the JAK2 gene as associated with MPN; JAK2 inhibition has therefore emerged as approach to MPN therapy.

14 Sep 2010

Age-related decline in executive function predicts better advice-giving

Sometimes elderly advice is the best advice, according to a new study from the Kellogg School of Management at Northwestern University. The research finds a silver lining to the negative effects of aging—older adults' declining ability to control their responses allows them to provide a greater quantity and quality of advice when it comes to uncomfortable social situations.

14 Sep 2010

Researchers identify body's control switch system to eliminate damaged cells

St. Jude Children's Research Hospital scientists discovered a new mechanism cells use to maximize production of a key protein following DNA damage and demonstrated the potential of small molecules to regulate the process and protect healthy tissue.

14 Sep 2010

Researchers identify novel molecular pathway of Parkinson’s disease

A new study led by researchers at Columbia University Medical Center has identified a novel molecular pathway underlying Parkinson's disease and points to existing drugs which may be able to slow progression of the disease.

14 Sep 2010

HFSA Meeting to discuss genomic diseases similarities in animals, humans

The 14th Annual Scientific Meeting of the Heart Failure Society of America (HFSA) will feature a discussion on the similarities in genomic diseases between animals and humans, titled "Comparative Genomics and Human Disease,Some Recent Contributions from Zoos."

14 Sep 2010

Molecule microRNA-21 enhances growth and survival of existing lung cancer

A tiny molecule that spurs the progression of non-small-cell lung cancer could become a player in fighting the disease, say researchers at UT Southwestern Medical Center, who published a study on how the molecule behaves in mice in the Sept. 14 issue of Cancer Cell.

14 Sep 2010

Depression in children and teens need to be treated early

Depression in children and teenagers can be very debilitating and can have a lifelong impact. Parents who suspect their child, even their youngster, might be depressed should seek help right away rather than simply hope their child will eventually "grow out of it."

14 Sep 2010

New electronic sensor detects pressure exerted by 20 milligram bluebottle fly carcass

The light, tickling tread of a pesky fly landing on your face may strike most of us as one of the most aggravating of life's small annoyances. But for scientists working to develop pressure sensors for artificial skin for use on prosthetic limbs or robots, skin sensitive enough to feel the tickle of fly feet would be a huge advance. Now Stanford researchers have built such a sensor.

14 Sep 2010

Researchers reveal new way of restraining beta-catenin to suppress tumor metastasis

Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis, the protein can be ejected from cells in small vesicles called exosomes. The study appears online on September 13 in the Journal of Cell Biology.

14 Sep 2010

Enlarged hearts regress faster in elderly women than in men after aortic valve replacement

Heart enlargement caused by narrowed aortic valves regresses faster in elderly women than in men after aortic valve replacement, according to research reported in a surgical supplement of Circulation: Journal of the American Heart Association.

14 Sep 2010

Trius Therapeutics reports torezolid antibiotic resistance mechanism for MRSA strains

Trius Therapeutics, Inc. today reported new findings on torezolid phosphate (TR-701), a second generation oxazolidinone antibiotic now in Phase 3 clinical development. The data elucidate the mechanism by which torezolid retains full activity against clinical isolates of Staphylococcus aureus (S. aureus) carrying the cfr gene which confers resistance to first generation oxazolidinones such as linezolid, marketed by Pfizer as Zyvox.

14 Sep 2010

Transgenomic expands EU distribution of SURVEYOR Scan K-RAS CE IVD mutation detection kit

Transgenomic, Inc. today announced that it completed the requirements for CE IVD labeling and has significantly expanded distribution of its SURVEYOR® Scan K-RAS mutation detection kit throughout most of the European Union. The SURVEYOR Scan K-RAS CE IVD kit is a member of Transgenomic's family of mutation detection kits, which features proprietary SURVEYOR endonuclease technology.

14 Sep 2010

Human cytomegalovirus cloned

A team of Welsh scientists have successfully cloned a human virus offering new hope for the treatment of potentially life-threatening diseases.

14 Sep 2010

Neural inhibition critical in ability to make choices

A new University of Colorado at Boulder study sheds light on the brain mechanisms that allow us to make choices and ultimately could be helpful in improving treatments for the millions of people who suffer from the effects of anxiety disorders.

14 Sep 2010

Study finds new therapeutic target for polycystic kidney disease

In work suggesting a new approach to treating polycystic kidney disease (PKD), a leading cause of kidney failure, researchers at Children's Hospital Boston were able to block the formation of fluid-filled cysts, the hallmark of the disease, in a mouse model. Their findings, using a compound that inhibits a receptor known as c-Met, will be published in the September 13th online edition of the Journal of Clinical Investigation.

14 Sep 2010

AstraZeneca, UCL collaborate to identify new therapeutic tools to modulate regenerative capacity of stem cells

AstraZeneca and UCL (University College London) today announced that they have entered into a collaboration to develop regenerative medicines for diabetic retinopathy (DR).

13 Sep 2010

Discovery shows how cells decide what to recycle, unlocking debilitating disease's secret

Our bodies recycle proteins, the fundamental building blocks that enable cell growth and development. Proteins are made up of a chain of amino acids, and scientists have known since the 1980s that first one in the chain determines the lifetime of a protein. McGill researchers have finally discovered how the cell identifies this first amino acid - and caught it on camera.

13 Sep 2010

Stem-cell research ban temporarily lifted in appeals court

On Friday, an appeals court temporarily stayed a judge's ban on the federal government's funding of embryonic stem-cell research, the The Associated Press/The Philadelphia Inquirer reports. "The National Institutes of Health said it was resuming its own research and would again evaluate applications from scientists who are seeking taxpayer money to do the work, a process that has been frozen since late last month."

13 Sep 2010

World's first reusable bio-chip for SNP genotyping market

Fluidigm Corporation today introduced its reusable FR48.48 Dynamic Array™ integrated fluidic circuit (IFC) - the world's first reusable bio-chip for the SNP genotyping market. This chip begins a new era of ultra-low cost, high sample throughput SNP genotyping and marks the beginning of Fluidigm's drive toward one-penny-per-data point.

13 Sep 2010

Geron, UCS collaborate to develop hESC-derived chondrocytes for cartilage damage, joint disease treatment

Geron Corporation today announced that the company has entered into a collaboration with University Campus Suffolk (UCS) in the U.K. to develop human embryonic stem cell-derived chondrocytes for the treatment of cartilage damage and joint disease.

13 Sep 2010

Medical Science News

New approach reduces JAK2 activity by pharmacologically targeting HSP90 protein

Age-related decline in executive function predicts better advice-giving

Researchers identify body's control switch system to eliminate damaged cells

Researchers identify novel molecular pathway of Parkinson’s disease

HFSA Meeting to discuss genomic diseases similarities in animals, humans

Molecule microRNA-21 enhances growth and survival of existing lung cancer

Depression in children and teens need to be treated early

New electronic sensor detects pressure exerted by 20 milligram bluebottle fly carcass

Researchers reveal new way of restraining beta-catenin to suppress tumor metastasis

Enlarged hearts regress faster in elderly women than in men after aortic valve replacement

Trius Therapeutics reports torezolid antibiotic resistance mechanism for MRSA strains

Transgenomic expands EU distribution of SURVEYOR Scan K-RAS CE IVD mutation detection kit

Human cytomegalovirus cloned

Neural inhibition critical in ability to make choices

Study finds new therapeutic target for polycystic kidney disease

AstraZeneca, UCL collaborate to identify new therapeutic tools to modulate regenerative capacity of stem cells

Discovery shows how cells decide what to recycle, unlocking debilitating disease's secret

Stem-cell research ban temporarily lifted in appeals court

World's first reusable bio-chip for SNP genotyping market

Geron, UCS collaborate to develop hESC-derived chondrocytes for cartilage damage, joint disease treatment

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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