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Ultrafine particle exposure may contribute to coronary heart disease risk in firefighters: Research

Exposure to high levels of ultrafine particles—invisible particles that can reach the smallest air passages in the lungs—may be an important contributor to the risk of coronary heart disease in firefighters, reports a study in the August Journal of Occupational and Environmental Medicine, official publication of the American College of Occupational and Environmental Medicine (ACOEM).

12 Aug 2010

Research reveals link between perception of intentions and evaluation of behavior

People generally like to see generous people rewarded and selfish people punished. Now, new research reveals a critical link between how we perceive another's intentions and our evaluation of their behavior. The study, published by Cell Press in the August 12 issue of the journal Neuron, makes some intriguing observations about how a description of the impact of an individual's actions on a group can alter the neural representation of their observed behavior.

12 Aug 2010

Numerate collaborates with Intellikine to identify drug-like inhibitors of PI3 kinase alpha

Numerate, Inc. and Intellikine, Inc. today announced the successful conclusion of their research collaboration to discover novel small molecule compounds targeting the PI3K/mTOR signaling pathway. The collaboration combined Intellikine's unique capabilities in x-ray crystal structure-guided medicinal chemistry and drug discovery with Numerate's powerful computational drug design platform to identify potent, selective and drug-like inhibitors of PI3 kinase alpha, an important target in cancer therapy.

12 Aug 2010

Omega-3 fatty acids consumption reduces age-related hearing loss: Research

Research continues to unveil potential benefits of omega-3 fatty acids found in seafood, pointing to healthful effects on the lungs in children, the uterus in women and hearing in older adults. The August 2010 PUFA Newsletter and Fats of Life e-newsletters for health professionals and consumers, respectively, report the latest findings about these and other topics.

12 Aug 2010

Human Immune Phenotyping Centers to receive NIAID grants for research

A new nationwide research initiative has been launched to define changes in the human immune system, using human and not animal studies, in response to infection or to vaccination. Six U. S.-based Human Immune Phenotyping Centers will receive a total of $100 million over five years to conduct this research.Funding for the centers is provided by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Support for the first year of this initiative will come from the American Recovery and Reinvestment Act.

12 Aug 2010

Increased brain activity predicts anxious temperament in young primates

A new study focused on anxiety and brain activity pinpoints the brain regions that are relevant to developing childhood anxiety. The findings, published in the Aug. 12 edition of the journal Nature, may lead to new strategies for early detection and treatment of at-risk children.

12 Aug 2010

Researchers find transposons determine differences in physical traits, disease risks

Building on a tool that they developed in yeast four years ago, researchers at the Johns Hopkins University School of Medicine scanned the human genome and discovered what they believe is the reason people have such a variety of physical traits and disease risks.

12 Aug 2010

Alectos Therapeutics collaborates with Merck for Alzheimer’s disease research

Alectos Therapeutics Inc. today announced a research collaboration with Merck, headquartered in Whitehouse Station, N.J., to identify and develop compounds that modulate O-linked N-acetylglucosaminidase (O-GlcNAcase) an enzyme that is believed to be involved in the development of Alzheimer's disease and potentially other disorders. The agreement provides Merck with a worldwide, exclusive license to research, develop and commercialize compounds that modulate this target.

12 Aug 2010

Secret of building muscle using light weights

Current gym dogma holds that to build muscle size you need to lift heavy weights. However, a new study conducted at McMaster University has shown that a similar degree of muscle building can be achieved by using lighter weights. The secret is to pump iron until you reach muscle fatigue.

12 Aug 2010

Research identifies abnormal huntingtin protein critical for mitosis and cell fate determination

New research finds that a protein that is often mutated in Huntington's disease (HD) plays an unexpected role in the process of neurogenesis. The research, published by Cell Press in the August 12 issue of the journal Neuron, provides new insight into HD pathology and has even broader implications for human health and disease.

12 Aug 2010

NeoStem, Schepens Eye Research Institute collaborate to develop therapies for AMD and Glaucoma

NeoStem, Inc., an international biopharmaceutical company with operations in the U.S. and China, announced today that it has entered into a sponsored research agreement (SRA) with the Schepens Eye Research Institute, a charitable corporation of Massachusetts and an affiliate of Harvard Medical School.

12 Aug 2010

Scientists find therapeutic potential of stem cells for acute lung injury

Researchers are reporting this week new study results they say provide further evidence of the therapeutic potential of stem cells derived from bone marrow for patients suffering from acute lung injury, one of the most common causes of respiratory failure in intensive care units.

12 Aug 2010

Venom-based nanoparticles improve gene therapy for fighting glioma

An ingredient in the venom of the "deathstalker" scorpion could help gene therapy become an effective treatment for brain cancer, scientists are reporting. The substance allows therapeutic genes - genes that treat disease - to reach more brain cancer cells than current approaches, according to the study in ACS Nano, a monthly journal.

12 Aug 2010

Einstein College receives grant to develop stem cell-based therapies

Scientists at Albert Einstein College of Medicine of Yeshiva University have received a five-year, $10.8 million grant to develop stem cell-based therapies that could be used to mitigate radiation-induced gastrointestinal syndrome - part of acute radiation syndrome (ARS) - for military personnel, first responders and the general public. The Einstein research, funded by the federal Centers for Medical Countermeasures Against Radiation, is part of a program coordinated by the National Institute of Allergy and Infectious Diseases.

12 Aug 2010

Sage Science introduces Pippin Prep DNA size selection system in US markets

Sage Science, Inc. announced today the release of the Pippin Prep DNA size selection system to the United States market. This device automates the collection of DNA fragments for next generation sequencing library preparations, and replaces manual gel purification techniques that typically require hours of effort.

12 Aug 2010

Chimpanzee adenoviruses can be used as vaccine vectors: Research

In recent years, scientists have studied the possibility of using engineered human adenoviruses as vaccines against diseases such as HIV, tuberculosis, and malaria. In this approach, adenoviruses, which commonly cause respiratory-tract infections, are rendered relatively harmless before they are used as vectors to deliver genes from pathogens, which in turn stimulate the body to generate a protective immune response.

12 Aug 2010

Needle-free natural vaccine against malaria: Research

A study published in the journal Science Translational Medicine proposes that preventative treatment with affordable and safe antibiotics in people living in areas with intense malaria transmission has the potential to act as a 'needle-free' natural vaccine against malaria and may likely provide an additional valuable tool for controlling and/or eliminating malaria in resource-poor settings.

12 Aug 2010

NMDP applauds introduction of 'Stem Cell Therapeutic and Research Reauthorization Act of 2010'

The National Marrow Donor Program today applauded the introduction of the "Stem Cell Therapeutic and Research Reauthorization Act of 2010." Sens. Orrin Hatch (R-UT), Christopher Dodd (D-CT), Richard Burr (R-NC), Jack Reed (D-RI), John Ensign (R-NV), and Al Franken (D-MN) introduced the act in the U.S. Senate as S. 3751 on Thursday, Aug. 5. Last evening, Reps. C.W. Bill Young (R-FL) and Doris Matsui (D-CA) introduced the companion legislation, (H.R. 6081), in the House.

11 Aug 2010

USPTO allows Regulus Therapeutics' claims of key Tuschl III patent covering Mir-155

Regulus Therapeutics Inc. announced today that the United States Patent and Trademark Office has allowed claims in a patent application (US Serial No. 12/550,579) derived from the "Tuschl III" patent series. The allowed claims relate to human microRNA miR-155, a microRNA that is a potential target for immuno-inflammatory indications, and a lead program of the Regulus-GSK Strategic Alliance.

11 Aug 2010

Silence Therapeutics receives patent for RNA silencing method

Silence Therapeutics plc announces the issuance of United States patent 7,772,203, titled "Methods and Compositions for Controlling Efficacy of RNA Silencing," by the United States Patent and Trademark Office (USPTO). The issued patent generally claims methods of enhancing RNA silencing with a double stranded RNA interference (RNAi) agent. The patent's RNA silencing method claims include coverage for the administering of a pharmaceutical composition containing short interfering RNA (siRNA), micro RNA (miRNA), pre-miRNA or short hairpin (shRNA) molecules. Silence believes the proprietary structural modification techniques covered in this patent will play a key role in increasing the potential therapeutic efficacy of RNAi therapeutics.

11 Aug 2010

Medical Science News

Ultrafine particle exposure may contribute to coronary heart disease risk in firefighters: Research

Research reveals link between perception of intentions and evaluation of behavior

Numerate collaborates with Intellikine to identify drug-like inhibitors of PI3 kinase alpha

Omega-3 fatty acids consumption reduces age-related hearing loss: Research

Human Immune Phenotyping Centers to receive NIAID grants for research

Increased brain activity predicts anxious temperament in young primates

Researchers find transposons determine differences in physical traits, disease risks

Alectos Therapeutics collaborates with Merck for Alzheimer’s disease research

Secret of building muscle using light weights

Research identifies abnormal huntingtin protein critical for mitosis and cell fate determination

NeoStem, Schepens Eye Research Institute collaborate to develop therapies for AMD and Glaucoma

Scientists find therapeutic potential of stem cells for acute lung injury

Venom-based nanoparticles improve gene therapy for fighting glioma

Einstein College receives grant to develop stem cell-based therapies

Sage Science introduces Pippin Prep DNA size selection system in US markets

Chimpanzee adenoviruses can be used as vaccine vectors: Research

Needle-free natural vaccine against malaria: Research

NMDP applauds introduction of 'Stem Cell Therapeutic and Research Reauthorization Act of 2010'

USPTO allows Regulus Therapeutics' claims of key Tuschl III patent covering Mir-155

Silence Therapeutics receives patent for RNA silencing method

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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