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Study finds changes in astrocytes key to brain dysfunction

Neuroscience researchers have zeroed in on a novel mechanism that helps control the firing of electrical signals among neurons. By isolating the molecular and electrical events that occur when this control is disrupted, the new research sheds light on epileptic seizures and potentially on other prominent diseases involving poorly regulated brain activity.

26 Apr 2010

GBS serotype III more commonly associated with urinary tract infections

Research suggests pathogenic strains of Group B Streptococcus (GBS) are an under-recognised cause of urinary tract infections.

24 Apr 2010

Targeted therapy based on molecular signatures for treating lung cancer

The first lung cancer clinical trial to guide targeted therapies to patients based on molecular signatures in tumor biopsies is a step toward personalized care and more effective, efficient clinical trials for new drugs, study leaders reported today during the American Association for Cancer Research 101st Annual Meeting 2010.

24 Apr 2010

Temperature-sensing ability in proteins remain a mystery

Scientists at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have shed new light on the molecular mechanism that enables us to sense temperature, such as the heat from a sizzling stove. In addition to contributing to our knowledge of basic biology, the findings could one day lead to new therapies for conditions such as acute or chronic inflammatory pain.

24 Apr 2010

New understanding of nerve cell influence in exchange of information

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present chloride channels remained obscure, although some theories predicted a relation between the chloride channel ClC-2 and epilepsy.

24 Apr 2010

Mechanisms pathogenic viruses exploit to evade immune systems of hosts

Viruses have evolved a broad range of strategies that enable them to evade the immune systems of their hosts. A team of researchers led by LMU virologist Professor J-rgen Haas has been studying a novel, recently discovered mechanism that pathogenic viruses exploit for this purpose, and their latest results could point the way to new antiviral therapies. The mechanism is based on the production of short RNA molecules, called microRNAs, by the virus.

24 Apr 2010

HeartWare International presents clinical trial data of Ventricular Assist System at ISHLT annual meeting

HeartWare International, Inc., a leading innovator of less invasive, miniaturized circulatory support technologies revolutionizing the treatment of advanced heart failure, today announced that data from its international clinical trial and commercial experience of the HeartWare® Ventricular Assist System showed a survival rate of 90 percent at six months and an actuarial survival rate of 86 percent at 12 months post implant.

24 Apr 2010

Current concepts and recent research findings on gene therapy for inner ear disorders

Gene therapy holds great potential for the treatment not only of genetic disorders, but also of many acquired diseases. This is as true for the inner ear as for any other organ. However, the technical challenges that must be overcome before gene therapy becomes more widely used are remarkable. In the inner ear the size, accessibility, delicacy and the involvement of many different cell types present unique conditions.

24 Apr 2010

Animal studies demonstrate safety profile of ACT's RPE cell therapy for SMD

Advanced Cell Technology, Inc. announced today that it has completed key animal studies in connection with its Phase I multicenter study using embryonic stem cell derived Retinal Pigment Epithelium (RPE) cells to treat patients with Stargardt's Macular Dystrophy (SMD), for which it filed an Investigational New Drug Application (IND) with the US Food and Drug Administration (FDA) in November. The studies demonstrated an excellent safety profile with no safety signals such as tumors or ectopic tissues.

24 Apr 2010

AlloMap molecular expression test reduces need for invasive heart-muscle biopsies

Monitoring rejection in heart transplantation patients with a simple blood test co-developed by NewYork-Presbyterian Hospital/Columbia University Medical Center physician-scientist Dr. Mario Deng in 2005 can safely reduce their need for invasive heart-muscle biopsies, a new study has found.

24 Apr 2010

Trinean launches DropSense96 and DropPlate 16 G for genomic DNA quantification

Only 6 months after the release of its ground-breaking DropSense 96 spectrophotometer, Trinean, pioneer in high throughput analysis of droplets of samples in microfluidic structures, is now launching another device that will set the tone in scientific circles: the DropPlate 16 G. This upgrade of the current microfluid disposable, the DropPlate 16 U, allows researchers to quantify 96 DNA/RNA samples of only 2 microl in less than 5 minutes.

24 Apr 2010

RXi Pharmaceuticals to present data on rxRNA therapeutic platform development at upcoming conferences

RXi Pharmaceuticals Corporation, a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today announced that senior members of its management will be presenting at upcoming conferences and will highlight critical aspects of the development of RXi's next generation rxRNA™ therapeutic platform as well as specific preclinical data generated with this platform.

24 Apr 2010

Environmental factors may play bigger role in tumor development: BIDMC study

It is an accepted fact that genetics play a key role in a person's susceptibility to cancer, and that throughout life, mutations can cause damage to tumor suppressor genes further increasing the chances of developing cancerous tumors.

24 Apr 2010

Johns Hopkins scientist receives AACR Award for Outstanding Achievement in Cancer Research

Joshua T. Mendell, M.D., Ph.D., an associate professor in the McKusick-Nathans Institute of Genetic Medicine at the Johns Hopkins University School of Medicine, and a Howard Hughes Medical Institute Early Career Scientist, is the recipient of the 30th annual American Association for Cancer Research Award for Outstanding Achievement in Cancer Research.

24 Apr 2010

Researchers discover and characterize general mechanism controlling transcription elongation in bacteria

Researchers from NYU Langone Medical Center have discovered and characterized a general mechanism that controls transcription elongation in bacteria. The mechanism, described in the April 23 issue of Science, relies on physical cooperation between a moving ribosome and RNA polymerase (RNAP) that allows for a precise adjustment of the transcriptional yield in response to translational needs. The study could lead to the development of new ways to interfere with bacterial gene expression and serve as a new target for antimicrobial therapy.

23 Apr 2010

Team liberates cellular hostages by silencing Toxoplasma gondii's back-seat driving

Scientists studying a cunning parasite that has commandeered the cells of almost half the world's human population have begun to zero in on the molecular signals that must be severed to free the organism's cellular hostages.

23 Apr 2010

InVivo Therapeutics CEO to be honored as one of Irish Life Science 50

InVivo Therapeutics Corporation CEO Frank Reynolds will be honored by the Irish Voice and Irish America Magazine, in collaboration with the Irish Government, as one of the 'Irish Life Science 50.' The award is the first honor to be given to influential Irish Americans for their work in the field of life sciences and is aimed to recognize "diverse accomplishments and advancements in the industry," according the Irish Voice.

23 Apr 2010

GIS scientists' zebrafish model may aid drug development for PD

Scientists at the Genome Institute of Singapore, a biomedical research institute of the Agency for Science, Technology and Research, have recently developed a zebrafish model for Parkinson's disease that can be used for understanding the mechanism underlying its development. The knowledge gained will be helpful for future screening of new drugs to treat Parkinson's disease.

23 Apr 2010

Research into Planarian worm 'Smed-prep' gene may pave way for regeneration of human organs

Scientists at The University of Nottingham have discovered the gene that enables an extraordinary worm to regenerate its own body parts after amputation — including a whole head and brain.

23 Apr 2010

Crystal structures of key fluorescent proteins to "light up" molecules in cells

Scientists at Albert Einstein College of Medicine of Yeshiva University have determined the crystal structures of two key fluorescent proteins - one blue, one red - used to "light up" molecules in cells.

23 Apr 2010

Medical Science News

Study finds changes in astrocytes key to brain dysfunction

GBS serotype III more commonly associated with urinary tract infections

Targeted therapy based on molecular signatures for treating lung cancer

Temperature-sensing ability in proteins remain a mystery

New understanding of nerve cell influence in exchange of information

Mechanisms pathogenic viruses exploit to evade immune systems of hosts

HeartWare International presents clinical trial data of Ventricular Assist System at ISHLT annual meeting

Current concepts and recent research findings on gene therapy for inner ear disorders

Animal studies demonstrate safety profile of ACT's RPE cell therapy for SMD

AlloMap molecular expression test reduces need for invasive heart-muscle biopsies

Trinean launches DropSense96 and DropPlate 16 G for genomic DNA quantification

RXi Pharmaceuticals to present data on rxRNA therapeutic platform development at upcoming conferences

Environmental factors may play bigger role in tumor development: BIDMC study

Johns Hopkins scientist receives AACR Award for Outstanding Achievement in Cancer Research

Researchers discover and characterize general mechanism controlling transcription elongation in bacteria

Team liberates cellular hostages by silencing Toxoplasma gondii's back-seat driving

InVivo Therapeutics CEO to be honored as one of Irish Life Science 50

GIS scientists' zebrafish model may aid drug development for PD

Research into Planarian worm 'Smed-prep' gene may pave way for regeneration of human organs

Crystal structures of key fluorescent proteins to "light up" molecules in cells

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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