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Scientists go beyond single-gene models to probe inborn heart defects

Studying genes that regulate early heart development in animals, scientists have solved a puzzle about one gene's role, finding that it acts in concert with a related gene. Their finding contributes to understanding how the earliest stages of heart development may go awry, resulting in congenital heart defects in humans.

12 Jan 2010

Abraxis Bioscience awards John Wayne Cancer Institute $1M grant for identifying new cancer biomarkers

A $1 million grant from Abraxis Bioscience, Inc. to a world-famous research laboratory at John Wayne Cancer Institute at Saint John’s Health Center could help save lives of cancer patients by helping doctors more rapidly assess whether a treatment is working or not.

12 Jan 2010

3D structure of PI3Kdelta: An important drug target for a wide range of diseases

Intellikine announced today the publication of an article entitled, "The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors," now available as an advanced online publication at Nature Chemical Biology.

12 Jan 2010

Evidence-based care for lung cancer patients results in an average cost savings of 35%, says study

A study recently conducted by US Oncology and Aetna finds that evidence-based care for patients with non-small cell lung cancer (NSCLC) results in an average cost savings of 35 percent over 12 months while demonstrating equivalent health outcomes. The study, which compared patients treated with evidence-based guidelines (also known as ‘on pathway’) to those treated with non-evidence-based guidelines (also known as ‘off pathway’), was published in the peer-reviewed Journal of Oncology Practice.

12 Jan 2010

Experts to present latest research findings on reproductive medicine at ESHRE 26th annual meeting

Reproductive medicine is one of the most exciting scientific and clinical areas. Every month different announcements of research developments, medical 'firsts', new rulings by regulatory bodies, or ethical controversies are published and often spark a heated debate among practitioners in the field, as well as ethicists, legislators, the media and the public.

12 Jan 2010

Ongoing pressures of human evolution could explain rise in disorders; scientists call for broader perspective

The subtle but ongoing pressures of human evolution could explain the seeming rise of disorders such as autism, autoimmune diseases, and reproductive cancers, researchers write in the Proceedings of the National Academy of Sciences.

12 Jan 2010

Ubiquitin-conjugating enzyme promotes chromosome missegregation and tumor formation

A ubiquitin-conjugating enzyme that regulates the cell cycle promotes chromosome missegregation and tumor formation, according to van Ree et al. in the January 11 issue of the Journal of Cell Biology (www.jcb.org).

12 Jan 2010

Stem cell therapy holds promise as potential alternative to bone grafting operations

A study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.

12 Jan 2010

Tocotrienol form of vitamin E prevents neural cell death and rescues the brain after stroke injury

Blocking the function of an enzyme in the brain with a specific kind of vitamin E can prevent nerve cells from dying after a stroke, new research suggests.

12 Jan 2010

Protein bits produced by unusual "reading" of HIV genome can induce immune responses

Two new studies showing that protein bits produced by unusual "reading" of the HIV genome can induce immune responses will appear online in the Journal of Experimental Medicine on Jan. 11 (www.jem.org).

12 Jan 2010

CDS Investigator Group identifies a new predictor for successful corneal transplant

A new predictor of cornea transplant success has been identified by the Cornea Donor Study (CDS) Investigator Group. New analysis of data from the 2008 Specular Microscopy Ancillary Study (SMAS), a subset of the CDS, found that the preoperative donor cell count of endothelial cells, previously considered to be an important predictor of a successful transplant, did not correlate with graft success.

12 Jan 2010

Experiments show Alzheimer's drug may halt the growth of oesophageal cancer

Cancer of the gullet, or oesophagus, is one of the ten most common cancers in the Western world, and there have been recent alarming increases in the number of cases each year in the US and UK.

12 Jan 2010

New blood test to identify changes in DNA linked with colorectal cancer now available in the U.S.

A new blood test that identifies changes in DNA associated with colorectal cancer is now available in the U.S. through Quest Diagnostics Incorporated, the world's leading cancer diagnostics company. The test is designed to aid the detection of colorectal cancer, the third leading cause of cancer-related deaths.

12 Jan 2010

PDGFR's role in new blood vessel formation may explain cardiovascular side effects

A growth factor that is a common target of cancer drugs also plays an important role in the heart's response to stress, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Journal of Clinical Investigation.

12 Jan 2010

Nominations open for third annual award for ‘Excellence in Science and Medical Journalism’

The Endocrine Society is calling for nominations for the third annual Award for Excellence in Science and Medical Journalism. The award recognizes outstanding reporting that enhances public understanding of health issues pertaining to the field of endocrinology.

12 Jan 2010

Researchers identify genetic variant linked with the risk of prostate cancer

Researchers at Wake Forest University Baptist Medical Center and colleagues have identified the first genetic variant associated with aggressive prostate cancer, proving the concept that genetic information may one day be used in combination with other factors to guide treatment decisions.

12 Jan 2010

University of Haifa receives grant to investigate role of protein expression in memory formation

Prof. Kobi Rosenblum, Head of the Department of Neurobiology and Ethology at the University of Haifa, has been awarded a -1.6 million grant from DIP, a German-Israeli Project Cooperation, over a five-year period. This grant will fund Prof. Rosenblum's international research of the role of protein expression in memory formation and stability.

12 Jan 2010

Researchers discover new ways for treatment of cancer

Researchers at the Swedish medical university Karolinska Institutet have discovered a new way of blocking the formation of blood vessels and halting the growth of tumours in mice. A substance that exploits this mechanism could be developed into a new treatment for cancer.

12 Jan 2010

New therapeutic treatment may provide a potential alternative to bone grafting operation

A study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.

12 Jan 2010

Exercise may improve cognitive function

Moderate physical activity performed in midlife or later appears to be associated with a reduced risk of mild cognitive impairment, whereas a six-month high-intensity aerobic exercise program may improve cognitive function in individuals who already have the condition, according to two reports in the January issue of Archives of Neurology, one of the JAMA/Archives journals.

11 Jan 2010

Medical Science News

Scientists go beyond single-gene models to probe inborn heart defects

Abraxis Bioscience awards John Wayne Cancer Institute $1M grant for identifying new cancer biomarkers

3D structure of PI3Kdelta: An important drug target for a wide range of diseases

Evidence-based care for lung cancer patients results in an average cost savings of 35%, says study

Experts to present latest research findings on reproductive medicine at ESHRE 26th annual meeting

Ongoing pressures of human evolution could explain rise in disorders; scientists call for broader perspective

Ubiquitin-conjugating enzyme promotes chromosome missegregation and tumor formation

Stem cell therapy holds promise as potential alternative to bone grafting operations

Tocotrienol form of vitamin E prevents neural cell death and rescues the brain after stroke injury

Protein bits produced by unusual "reading" of HIV genome can induce immune responses

CDS Investigator Group identifies a new predictor for successful corneal transplant

Experiments show Alzheimer's drug may halt the growth of oesophageal cancer

New blood test to identify changes in DNA linked with colorectal cancer now available in the U.S.

PDGFR's role in new blood vessel formation may explain cardiovascular side effects

Nominations open for third annual award for ‘Excellence in Science and Medical Journalism’

Researchers identify genetic variant linked with the risk of prostate cancer

University of Haifa receives grant to investigate role of protein expression in memory formation

Researchers discover new ways for treatment of cancer

New therapeutic treatment may provide a potential alternative to bone grafting operation

Exercise may improve cognitive function

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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