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A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability

In an accomplishment that represents a significant step toward an era of rapid, inexpensive, bedside testing for cancer, researchers at the University of Virginia have developed a microfluidic device that can process human blood samples and yield diagnostic results within an hour.

8 Jan 2007

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

By combining a quantum dot with a novel carrier of the magnetic resonance imaging (MRI) agent gadolinium, a team of investigators at the University of Maastricht, in The Netherlands, has developed a nanoparticle that can spot apoptosis, or programmed cell death, using both MRI and fluorescence imaging.

8 Jan 2007

Dendrimer-encapsulated camptothecins

With an eye toward developing a delivery vehicle for anticancer agents that are poorly soluble in water, a research team at Boston University and the Research Triangle Institute (RTI) has developed a biocompatible dendrimer that wraps itself around water-insoluble drugs.

8 Jan 2007

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

In the first experiment of its kind, investigators at the Center for Cancer Nanotechnology Excellence Focused on Therapy Response (CCNE-TR), based at Stanford University, have shown that single-walled carbon nanotubes (SWCNTs) wrapped in poly(ethylene glycol), or PEG, can successfully target tumors in living animals.

8 Jan 2007

Stem cells grown into brain cells on a new 3D scaffold of tiny protein fragments

An MIT engineer and Italian colleagues will report the invention-which may one day replace the ubiquitous Petri dish for growing cells-in PLoS ONE.

2 Jan 2007

Scientists visualize influenza virus particles

Scientists at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and colleagues at the University of Virginia in Charlottesville have succeeded in imaging, in unprecedented detail, the virus that causes influenza.

2 Jan 2007

Characterizing the environmental, health, and safety implications of nanotechnology

A new analysis of the Federal government’s efforts to study the environmental, health, and safety (EHS) implications of nanotechnology concludes that sound management will play as important a role as good science when it comes to addressing these concerns.

18 Dec 2006

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

In an attempt to determine what factors make one nanoparticle better than another at targeting tumors, a team of investigators in Korea have conducted a systematic tumor-targeting study of a variety of self-assembling nanoparticles.

18 Dec 2006

Better magnetic nanoparticles

Using a polymer coating designed to resemble the outer surface of a cell membrane, a team of investigators led by Steve Armes, Ph.D., of the University of Sheffield in the United Kingdom, has created a highly stable, biocompatible magnetic nanoparticle expected to improve the sensitivity of magnetic resonance imaging (MRI).

18 Dec 2006

Aptamer-capped nanocrystal quantum dots

Quantum dots, used increasingly as bright fluorescent markers in basic research and diagnostic assays, must be coated, or capped, with one of a wide variety of organic molecules in order to stabilize these nanocrystals and prevent them from aggregating when added to water.

18 Dec 2006

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Though gene therapies hold great promise for treating cancer, it has proven difficult to deliver therapeutic genes efficiently into cancer cells.

18 Dec 2006

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

In the first experiments of their kind, researchers have determined that carbon nanotubes injected directly into the bloodstream of research lab animals cause no immediate adverse health effects and circulate for more than one hour before they are removed by the liver.

18 Dec 2006

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

Nanoscale, inorganic fluorescent imaging agents such as quantum dots have become an important tool for researchers studying key biomolecules involved in cancer.

18 Dec 2006

FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents

Alloys of iron and cobalt generate powerful magnetic signals that could be useful in nanoparticles designed to detect tumors using magnetic resonance imaging (MRI).

18 Dec 2006

Vascular targeted nanoparticles for imaging and treatment of brain tumors

Combining two promising approaches to diagnosing and treating cancer, a multidisciplinary research team at the University of Michigan has created a targeted multifunctional polymer nanoparticle that successfully images and kills brain tumors in laboratory animals.

4 Dec 2006

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

Waiting a day or more to get lab results back from the doctor's office soon could become a thing of a past.

4 Dec 2006

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

In attempt to identify biological markers, or biomarkers, that can signal the presence of cancer and help oncologists determine the best course of therapy when cancer is present, teams of investigators are scouring stored tissue samples obtained from thousands of cancer patients.

4 Dec 2006

Computational model for cancer invasion

Vito Quaranta clicks on a small black dot on his computer screen. The dot - which represents about a thousand cancer cells - begins to "grow," morphing into a mass with finger-like projections that looks like an invasive tumor.

2 Dec 2006

Genetically engineered blood protein can be used to split water into oxygen and hydrogen

Scientists have combined two molecules that occur naturally in blood to engineer a molecular complex that uses solar energy to split water into hydrogen and oxygen, says research published in the Journal of the American Chemical Society.

2 Dec 2006

Test strips for the rapid detection of cocaine

Saving the life of a poisoning victim is often a matter of minutes. It is best when the emergency doctor can perform a reliable diagnosis on the spot to determine which poison or what type of drug overdose a patient is suffering from. Complicated laboratory analyses and a complex apparatus are out of place in the emergency room.

21 Nov 2006

Medical Science News

A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

Dendrimer-encapsulated camptothecins

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

Stem cells grown into brain cells on a new 3D scaffold of tiny protein fragments

Scientists visualize influenza virus particles

Characterizing the environmental, health, and safety implications of nanotechnology

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

Better magnetic nanoparticles

Aptamer-capped nanocrystal quantum dots

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents

Vascular targeted nanoparticles for imaging and treatment of brain tumors

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

Computational model for cancer invasion

Genetically engineered blood protein can be used to split water into oxygen and hydrogen

Test strips for the rapid detection of cocaine

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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