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Smart hydrogel particles: biomarker harvesting

The long and challenging effort to find blood-borne markers for cancer and other diseases may soon enter a new realm of success using a new nanoparticle that preferentially and rapidly removes small proteins and other molecules from blood while simultaneously protecting them from degradation.

16 Jan 2008

Matrix metalloproteinase-assisted triggered release of liposomal contents

Cancer cells display a variety of proteins on their outer membranes that are not present on the surface of normal cells.

16 Jan 2008

Cancer cell targeting using multiple aptamers conjugated on nanorods

Aptamers, short stretches of DNA or RNA that can act much like antibodies, have shown promise as targeting agents for selective nanoparticle trafficking to tumors.

16 Jan 2008

Polymeric nanoparticles for tumor vaccines

The quest for an effective antitumor vaccine has received a boost from the results of work aimed at developing a nanoparticle that delivers tumor antigens to the immune system cells that trigger antibody production.

16 Jan 2008

New technique could dramatically lower costs of DNA sequencing

Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip.

16 Jan 2008

New research may shed light on how proteins interact with drugs and other small molecules

Proteins, the biological molecules involved in virtually every action of every organism, may themselves move in surprising ways, according to a recent study from the U.S. Department of Energy's Argonne National Laboratory that may shed new light on how proteins interact with drugs and other small molecules.

16 Jan 2008

Supercarrot to protect against bone diseases

American scientists have created a "supercarrot" which may protect against conditions such as brittle bone disease and osteoporosis.

16 Jan 2008

Molecular evolution of limb length

In the January 15th issue of G&D, a research team led by Dr. Richard Behringer at MD Anderson Cancer Center reports that they have successfully switched the mouse Prx1 gene regulatory element with the Prx1 gene regulatory region from a bat - and although these two species are separated by millions of years of evolution - the resulting transgenic mice displayed abnormally long forelimbs.

15 Jan 2008

A modified carrot for increased calcium absorption

A specially developed carrot has been produced to help people absorb more calcium.

15 Jan 2008

Why we sleep - roundworm C. elegans unlocks sleep mysteries

The roundworm C. elegans, a staple of laboratory research, may be key in unlocking one of the central biological mysteries: why we sleep.

15 Jan 2008

Gene detection platform made from self-assembled DNA nanostructures

Scientists at Arizona State University's Biodesign Institute have developed the world's first gene detection platform made up entirely from self-assembled DNA nanostructures.

11 Jan 2008

Germanium-68 may aid medical imaging, drug development

Broadway stars have understudies. Now, an increasingly popular radioactive isotope has its own stand-in.

10 Jan 2008

Evolution of the sexes: What a fungus can tell us

Fungi don't exactly come in boy and girl varieties, but they do have sex differences.

10 Jan 2008

When tsetse flies fall for a host, they keep coming back for more

If you like a restaurant first time around, you're likely to go back, aren't you? Well the same goes, more or less, for tsetse flies, as researchers from CIRAD, CIRDES and the University of Neuchâtel have recently demonstrated.

9 Jan 2008

Two proteins called BERT and ERNI interact in embryos to control brain development

Scientists at University College London have discovered how two proteins called BERT and ERNI interact in embryos to control when different organ systems in the body start to form, deepening our understanding of the development of the brain and nervous system and expanding our knowledge of stem cell behavior.

9 Jan 2008

Discovery of 480 genes that control human cell division

A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells.

8 Jan 2008

Salinispora tropica marine bacterium points to new ways to treat human diseases

An unexpected discovery in marine biomedical laboratories at Scripps Institution of Oceanography at UC San Diego has led to new, key information about the fundamental biological processes inside a marine organism that creates a natural product currently being tested to treat cancer in humans.

7 Jan 2008