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Computational design used to engineer and construct a protein that could sense the nerve agent soman

Duke University Medical Center biochemists have used computational design to engineer and construct a protein that could sense the nerve agent soman. They said their achievement constitutes a proof-of principle that such engineered proteins can be made to detect nerve agents such as sarin and other toxic substances.

5 Jun 2004

Proteins transform DNA into molecular velcro

Proteins critical for compacting DNA in preparation for cell division actually interact with the double helix to fashion it into a kind of “molecular Velcro,” researchers have discovered.

5 Jun 2004

New method for identifying proteins found in trace quantities in the blood

Using conventional technologies, researchers supported by the National Cancer Institute (Science Applications International Corporation-Frederick, Inc. (SAIC)) have developed a new method for identifying proteins found in trace quantities in the blood.

5 Jun 2004

Cure for age-induced diabetes or cancer may be nearer than we think

Forget the drastic reduction in carbs and calories called for by diet dictators. The day when people can eat their favorite foods, stay thin and live to be 120 without getting age-induced diabetes or cancer may be nearer than we think.

5 Jun 2004

Breakthrough in gene therapy

Despite a roller-coaster ride of ups and downs during the past 15 years, gene therapy has continued to attract many of the world's brightest scientists. They are tantalized by the enormous potential that replacing missing genes or disabling defective ones offers for curing diseases of many kinds.

3 Jun 2004

New way to identify when a living cell begins to grow

In a discovery that has relevance in a variety of fields, including human health, UC Riverside Assistant Professor of Biochemistry Frank Sauer and colleagues at UC Riverside, in Germany, and in Wisconsin, have found a new way to identify when a living cell begins to grow.

3 Jun 2004

How the brain interprets electrical impulses sent by neurons

University of California, San Diego neurobiologists have uncovered evidence that sheds light on the long-standing mystery of how the brain makes sense of the information contained in electrical impulses sent to it by millions of neurons from the body.

3 Jun 2004

Scientists reveal the crystal structure of the first described enzymatic RNA

Scientists in the department of molecular biophysics and biochemistry at Yale revealed the crystal structure of the first described enzymatic RNA - what it looks like and how it reacts - in the journal Nature.

2 Jun 2004

Genes that allow nerve cells to communicate may have come from bacteria eons ago

Some of the genes that allow nerve cells and some other types of cells to send elaborate chemical messages to each other appear to have been transferred to animals or their immediate ancestors from bacteria eons ago.

2 Jun 2004

Mice may hold the key to longer life

Scientists from the University of Aberdeen, the Aberdeen-based Rowett Research Institute and the Medical Research Council (MRC) in Cambridge have made a major breakthrough in understanding how metabolism affects lifespan.

2 Jun 2004

Engineered virus could be ideal for targeting cancers with lethal gene therapy

Scientists from Cancer Research UK have taken advantage of the selfish behaviour of cancer cells to target them with a genetically engineered virus.

1 Jun 2004

Cellular garbage plays a key role in the process of cytokinesis, or cell division

A cellular structure discovered 125 years ago and dismissed by many biologists as "cellular garbage" has been found to play a key role in the process of cytokinesis, or cell division, one of the most ancient and important of all biological phenomena.

27 May 2004

Blueprint for rational design of vaccines that induce desired T-cell responses

Investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have conducted studies in mice to gain a new picture of how the immune system’s “killer” T cells are prompted to destroy infected cells. Their insights provide a blueprint for rational design of vaccines that induce desired T-cell responses.

27 May 2004

Finding overturns long held ideas about how cells build proteins

Writing in the May 28 issue of Cell, Johns Hopkins researchers report that four critical components of cells' protein-building machine don't do what scientists had long assumed.

27 May 2004

Link between oral bacterium and premature babies

For years, scientists have noticed a particular oral bacterium can be found in the amniotic fluid of about 20 percent of women with premature babies.

27 May 2004

Toxoplasma gondii discovery may help fight against malaria

University of North Carolina at Chapel Hill scientists have discovered a protein in the cell wall of parasites that’s crucial to the molecular mechanism allowing them to move between cells, survive and cause disease.

25 May 2004

Baby born from 21 year old cryopreserved sperm

"We believe this is the longest period of sperm cryopreservation resulting in a live birth so far reported in the scientific literature," according to one of the authors, Dr Elizabeth Pease, Consultant in Reproductive Medicine at the Department of Reproductive Medicine at St Mary's Hospital, Manchester.

25 May 2004

X-ray beams could kick start genes into fighting cancer

X-ray beams could kick start genes into fighting cancer as an exciting new way of targeting therapy against the disease, according to new research in the Journal of Gene Medicine.

25 May 2004

Computer program to predict where DNA molecules will pop open when twisted

Biologists are used to thinking about DNA sequences as a string of letters (A, C, G, T) that happens to be arranged in an elegant double helix. But DNA also has mechanical properties that affect how genes are turned on or off, say researchers at the UC Davis Genome Center.

24 May 2004

A higher male susceptibility to disease has helped shape the evolution of social insect behavior

A pair of scientists has proposed a new model for behavioral development among social insects, suggesting that a higher male susceptibility to disease has helped shape the evolution of the insects' behavior.

24 May 2004