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Using advanced CRISPR to boost efficiency of CAR-T cell therapies

CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for treating acute lymphoblastic leukemia (ALL).

2 Aug 2024

Study reveals how coinfecting phages impede each other’s entry into bacterial cells

The process by which phages-;viruses that infect and replicate within bacteria-;enter cells has been studied for over 50 years.

2 Aug 2024

New research reveals keto diet’s impact on cholesterol and gut microbiome

A study from the University of Bath reveals that ketogenic low-carbohydrate diets can increase cholesterol levels and reduce beneficial gut bacteria, specifically Bifidobacterium.

2 Aug 2024

Study links e-cigarette use to increased respiratory symptoms

The association between electronic cigarette (EC) use and respiratory health in adults.

2 Aug 2024

Impact of early COVID-19 job loss on later mental health uncovered

How income or job loss during the initial phases of the coronavirus disease 2019 (COVID-19) pandemic is linked to subsequent psychological distress.

2 Aug 2024

Groundbreaking method dmSLAY improves antimicrobial peptide effectiveness and safety

Researchers developed a high-throughput method, dmSLAY, to assess thousands of AMP variants, combining it with machine learning to enhance membrane selectivity and reduce toxicity.

1 Aug 2024

St. Jude develops cost-effective genetic panel for pediatric cancer diagnosis

Scientists at St. Jude Children's Research Hospital have created a panel that is able to provide a diagnosis for >90% of pediatric cancer patients by sequencing 0.15% of the human genome.

1 Aug 2024

Upper airway swabs reveal rich, stable immune memory crucial for respiratory defense

Researchers discovered diverse and stable immune cell populations in the upper respiratory tract, highlighting the critical role of mucosal immunity in COVID-19 and other respiratory diseases.

1 Aug 2024

Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

In a groundbreaking study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

1 Aug 2024

Age and cultural pressures shape body appreciation among women worldwide

A study in PLOS ONE reveals that body appreciation is significantly influenced by ethnicity and sociocultural pressures, with Black Nigerian women reporting the highest satisfaction and White Western women the lowest.

1 Aug 2024

Uncontrolled hypertension: A persistent threat to global health

In the United States and worldwide, cardiovascular disease is the leading avoidable cause of premature death and disability. Primarily heart attacks and stroke, cardiovascular disease accounts for more than 900,000 annual deaths nationally and about 10 million deaths globally.

1 Aug 2024

New studies reveal common DNA replication mechanisms in humans and yeast

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Sciences.

1 Aug 2024

Fish oil may benefit older adults with genetic Alzheimer's risk

A clinical trial at Oregon Health & Science University suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

1 Aug 2024

Novel electrical impedance technique enhances drug testing for cardiac safety

When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical.

1 Aug 2024

INTEGRA Biosciences' pipettes are endorsed by ergonomics champion iHEALTH 360

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From INTEGRA Biosciences 1 Aug 2024

Continuous noninvasive blood pressure monitoring using resonance sonomanometry

Resonance sonomanometry (RSM) for noninvasive, calibration-free continuous blood pressure (BP) measurement using ultrasound imaging.

1 Aug 2024

The complex relationship between diet nutrition and cancer

The existing knowledge on the beneficial and detrimental effects of dietary patterns and nutritional supplements on cancer risk.

1 Aug 2024

Single-cell RNA sequencing sheds light on stroke-induced brain damage

Strokes lead to irreversible damage to the brain and are one of the most common causes of dependency or death.

1 Aug 2024

Highly inflammatory rheumatoid arthritis patients more susceptible to cognitive impairment

Researchers assessed cognitive function among rheumatoid arthritis patients with ongoing inflammatory activity.

1 Aug 2024

High-frequency eccentric resistance training decreases passive muscle stiffness

Resistance, or weight training, is widely recommended in sports and rehabilitation as an effective exercise to increase muscular strength and size. This form of exercise involves applying resistance to muscle contraction to build strength. However, some practitioners believe resistance training can increase passive muscle stiffness over time.

1 Aug 2024