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New zwitterionic polyion developed for effective plasmid DNA delivery in muscle cells

Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins.

28 Jul 2024

Ventilation must go beyond open windows to prevent airborne diseases, experts urge

Proper ventilation is crucial for preventing airborne transmission of pathogens, highlighting the need for better building design and public health guidelines post-COVID-19.

28 Jul 2024

Cytomegalovirus in breast milk linked to changes in infant growth and gut microbiome

Research shows human cytomegalovirus (CMV) reactivation in breast milk affects milk composition, infant gut microbiome, and growth, with potential impacts on neonatal health.

28 Jul 2024

Study finds genetic factors key to post-stroke cardiovascular risks

Research identifies genetic and molecular risk factors for cardiovascular outcomes after an initial stroke, uncovering potential therapeutic targets to improve patient prognoses.

28 Jul 2024

Research highlights emotional benefits and challenges of breast milk donation

Research reveals that donating breast milk positively impacts maternal well-being, while those unable to donate often experience negative emotions such as frustration and rejection

28 Jul 2024

Scientists explore early life factors contributing to SMA

Spinal muscular atrophy (SMA) is a severe neurological disease for which there is presently no cure, although current therapies can alleviate symptoms. In the search for better treatment options, scientists at DZNE and the Dresden University of Technology are now drawing attention to previously unnoticed abnormalities in embryonic development. They base their argument on studies of so-called organoids: Laboratory-grown tissue cultures that can reconstruct disease processes. Their findings are published in the journal Cell Reports Medicine.

27 Jul 2024

New study examines educational disruptions for children

Children with special health care needs (CSHCN) often face significant disruptions in their education due to extended hospitalizations. A recent study published online in Disability and Rehabilitation on July 1, 2024, by a multidisciplinary team of Kessler Foundation and Children Specialized Hospital.

27 Jul 2024

Breakthrough therapy heals spinal cord injuries

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries.

27 Jul 2024

Innovative dual-drug strategy for colorectal cancer treatment

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed.

27 Jul 2024

Inflammation may not be key to fighting liver fibrosis in MAFLD

Researchers at UCLA Health uncovered new information about the role inflammation plays in mitigating liver fibrosis, which is associated with metabolic-associated fatty liver disease (MAFLD), one of the most common diseases in the world affecting up to 40 percent of U.S. adults. While inflammation in the liver has long been considered a prerequisite to developing liver fibrosis, the scarring and thickening of tissue that can impair the liver's ability to function, this new research suggests that reducing inflammation may not influence the extent of fibrosis.

27 Jul 2024

New guidelines expand BRCA testing and screening for men

More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women.

27 Jul 2024

Physician posture impacts patient experience and outcomes

A new study suggests that getting at a patient's eye level when talking with them about their diagnosis or care can really make a difference. Sitting or crouching at a hospitalized patient's bedside was associated with more trust, satisfaction and even better clinical outcomes than standing, according to the new review of evidence.

26 Jul 2024

Cellular competition determines X chromosome usage in female bodies

A new study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences has reveals that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body. The study leverages human data from the 1000 Genomes Project combined with mouse models of human X chromosome-linked DNA sequence variation to advance our fundamental understanding of development in biologically female individuals who have two X chromosomes.

26 Jul 2024

Anxiety’s Long-Term Impact on Dementia Development

The longitudinal relationship between chronic, resolved, and new onset anxiety and the risk of all-cause dementia (Progressive cognitive decline affecting memory and thinking).

26 Jul 2024

Study reveals enhanced electron transport in folded peptides

What puts the electronic pep in peptides? A folded structure, according to a new study in the Proceedings of the National Academy of Sciences.

26 Jul 2024

Alarming spread of H5N1 bird flu in US dairy cattle reveals cross-species transmission dangers

Researchers discovered that the H5N1 avian influenza virus has spilled over into dairy cattle in the US, posing significant cross-species transmission risks. Their multidisciplinary study reveals the virus's evolution and its zoonotic potential, emphasizing the need for heightened biosecurity measures.

25 Jul 2024

COVID pandemic accelerated brain aging, especially in males and deprived groups

The COVID-19 pandemic accelerated brain aging, particularly in males and those from deprived backgrounds, with significant cognitive performance decline in infected individuals. This impact was observed regardless of COVID-19 infection status, highlighting the role of psychosocial stressors.

25 Jul 2024