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Researchers identify risk factors for SARS-CoV-2 reinfection

A team of scientists from the Capital Medical University and Peking University, China, has recently explored the factors responsible for the reactivation of SARS-CoV-2 infection among individuals who have recently recovered from COVID-19. The findings reveal that individuals with lower lymphocyte count or with two or fewer symptoms during the first COVID-19 episode are at higher risk of recurrent infection.

16 Apr 2021

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds

Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system.

16 Apr 2021

Rapid mRNA vaccination effectively controls SARS-CoV-2 transmission in long-term care facilities

Vaccine rollouts all over the world are aimed at cutting short the coronavirus disease 2019 (COVID-19) pandemic by inducing antibody-mediated immunity to the virus. A new study, recently released on the medRxiv* preprint server, addresses the successful reduction in viral spread and case incidence among residents of long-term care facilities (LTCF).

16 Apr 2021

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

A new study, released on the medRxiv* preprint server, examines the presence of SARS-CoV-2-specific IgA in human milk and its association with the protection of breastfed infants against the disease.

16 Apr 2021

Curcumin nanosystems could be powerful COVID-19 therapeutics

With new variants of SARS-CoV-2 emerging, the COVID-19 pandemic is far from over. While the global vaccine rollout has moved at an impressive speed, the search for new safe, effective, and targeted therapies is still on. Now, a new study reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanosystems to treat COVID-19.

16 Apr 2021

Researchers develop “Nano-Glue” with therapeutic potential against SARS-CoV-2

In a recent study, researchers target the electropositive receptor-binding domain (RBD) on the SARS-CoV-2 spike protein with the abundant β-sheet structure as a novel COVID-19 therapeutic drug design.

15 Apr 2021

Can biomaterials offer novel therapeutic strategies against COVID-19?

A team of scientists reviews the current and potential impact of the biomaterial sciences on the COVID-19 pandemic.

15 Apr 2021

Allometric model shows human travel is closely related to spread of COVID-19

A new study indicates that the spread of COVID-19 is governed by power-law dynamics, suggesting that alternative modeling approaches need to be used to understand and predict its propagation.

15 Apr 2021

Early monoclonal antibody therapies beneficial for COVID-19, finds study

A team of scientists recently conducted a large-scale study at Northwell Health, New York, USA, to evaluate the efficacy of neutralizing monoclonal antibody (MAB) therapies in preventing disease progression among patients with mild to moderate COVID-19. The findings reveal that the timing of initiating MAB therapy is a crucial factor in determining its efficacy against COVID-19.

14 Apr 2021

Small molecule inhibitors of SARS-CoV-2 identified by screening

A new study describes the identification of small molecule inhibitors that block the catalytic activity of the crucial viral non-structural protein 5 (nsp5), using a large-scale screening method.

12 Apr 2021

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

A new preprint, recently released on the bioRxiv* server, explores the impact of a single mutation, the P681H mutation, on the transmissibility of the virus.

12 Apr 2021

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Many different variants and lineages have arisen from the ancestral Wuhan-Hu1 strain of the SARS-CoV-2. This requires careful attention to control measures since many are more infective and transmissible than the older strains. A recent study compares the UK variant of this virus with the wildtype in terms of susceptibility to routine cleaning and disinfection measures.

12 Apr 2021

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the bioRxiv* preprint server.

12 Apr 2021

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Even as vaccines against SARS-CoV-2 are being developed and administered at an unprecedented pace, treating this infection remains a challenge. To address this, researchers from China have used nanobodies (Nb) as a possible therapeutic approach. They reported Nb phage display libraries derived from four camels immunized with the SARS-CoV-2 spike RBD.

12 Apr 2021

SARS-CoV-2 spike E484K mutation reduces antibody neutralization

Researchers at the Department of Microbiology, Icahn School of Medicine at Mount Sinai New York, USA, showed that the SARS-CoV-2 spike E484K mutation reduces antibody neutralization.

12 Apr 2021

Researchers identify several novel SARS-CoV-2 inhibitors

Researchers in London, UK, have identified several compounds with SARS-CoV-2 inhibiting properties, that potentially may be developed into antiviral solutions in the future.

9 Apr 2021

Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants

A new monoclonal antibody targets a particular region of the RBD on the SARS-CoV-2. This region is usually not accessible to immune cells, which may be why it has broad neutralizing capabilities.

9 Apr 2021

How has the COVID-19 pandemic affected sleep patterns for many US citizens?

A team of scientists recently conducted an online survey to examine the changes in sleep duration among adult US citizens during the COVID-19 pandemic.

9 Apr 2021

Autoantibodies may contribute to severe COVID-19 and potential long-COVID-19 symptoms

New research in the USA and China. investigated how autoantibodies could mediate NETs during a COVID-19 infection. Extensive damage to the body from neutrophil extracellular traps (NETs) after infection may be contributing to thromboinflammation and the symptoms experienced by COVID-19 ‘long-haulers’.

8 Apr 2021

Enhanced neutralization of SARS-CoV-2 South African variant with heterologous adjuvant vaccine candidate

A new study describes the use of a single dose of vaccine based on the viral protein called the receptor-binding domain (RBD) to elicit powerful neutralizing activity against both the Wuhan strain and the most concerning VOC called the South African (SA) strain.

7 Apr 2021

Miscellaneous News

Researchers identify risk factors for SARS-CoV-2 reinfection

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds

Rapid mRNA vaccination effectively controls SARS-CoV-2 transmission in long-term care facilities

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

Curcumin nanosystems could be powerful COVID-19 therapeutics

Researchers develop “Nano-Glue” with therapeutic potential against SARS-CoV-2

Can biomaterials offer novel therapeutic strategies against COVID-19?

Allometric model shows human travel is closely related to spread of COVID-19

Early monoclonal antibody therapies beneficial for COVID-19, finds study

Small molecule inhibitors of SARS-CoV-2 identified by screening

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

SARS-CoV-2 spike E484K mutation reduces antibody neutralization

Researchers identify several novel SARS-CoV-2 inhibitors

Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants

How has the COVID-19 pandemic affected sleep patterns for many US citizens?

Autoantibodies may contribute to severe COVID-19 and potential long-COVID-19 symptoms

Enhanced neutralization of SARS-CoV-2 South African variant with heterologous adjuvant vaccine candidate

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