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New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

SARS-CoV-2, the respiratory virus that causes COVID-19, attacks the body in multiple steps. Gaining entry into cells deep within the lungs and hijacking the human host cell's machinery to churn out copies of itself are two of the earliest steps -- both essential for viral infection.

9 Nov 2020

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

The American College of Rheumatology (ACR) will preview its 2020 Guideline for the Management of Rheumatoid Arthritis (RA) at ACR Convergence, the ACR's annual meeting. The comprehensive, clinical recommendations for pharmacologic treatment of RA includes important updates to the previous guideline released in 2015.

9 Nov 2020

FDA releases final guidance to help identify and prevent insanitary conditions at compounders’ facilities

Protecting patients from exposure to poor quality compounded drugs is a fundamental part of the U.S. Food and Drug Administration's drug compounding program, and we are committed to protecting patients.

6 Nov 2020

Patients with rheumatic diseases reported antimalarial drug shortages during COVID-19

A new study shows that patients with rheumatic diseases across Africa, Southeast Asia, the Americas and Europe had trouble filling their prescriptions of antimalarial drugs, including hydroxychloroquine, during the 2020 global coronavirus pandemic, when antimalarials were touted as a possible COVID-19 treatment.

6 Nov 2020

Hydroxychloroquine not associated with prolonged heart rhythm intervals in RA or lupus patients

New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, discovers that use of hydroxychloroquine, a generic drug, does not cause any significant differences in QTc length or prolonged QTc, key measures of heart rate, in people with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE).

6 Nov 2020

Oral methotrexate can be an effective intervention for people with knee OA

A new study presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that after three months of treatment with oral methotrexate, adults with primary knee osteoarthritis (OA) with inflammation had significant improvements in physical function and inflammation, a sign that this inexpensive, generic pill may be an important intervention for knee OA.

6 Nov 2020

TB screening needed for people on methotrexate who live in at-risk areas

New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that tuberculosis (TB) screening and ongoing clinical care is needed for people on methotrexate who live in areas where the highly infectious illness is common.

6 Nov 2020

Osteoporosis drug increases bone mineral density in the hip and lumbar spine

New research presented at ACR Convergence, the American College Rheumatology's annual meeting, reveals that romosozumab, an osteoporosis drug, produces substantial gains in bone mineral density in the hip and lumbar spine within one year, and that transitioning patients to a potent antiresorptive drug can lead to even more bone density gains.

6 Nov 2020

Commonly prescribed anti-depressant may halt the growth of childhood sarcoma

A new study has found that a commonly prescribed anti-depressant may halt growth of a type of cancer known as childhood sarcoma, at least in mice and laboratory cell experiments.

6 Nov 2020

Researchers develop novel chemo-immunotherapy agent to treat pancreatic tumors

Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis.

6 Nov 2020

New resource can help predict drug sensitivity and optimize therapeutic strategies

Through large-scale profiling of protein changes in response to drug treatments in cancer cell lines, researchers at The University of Texas MD Anderson Cancer Center have generated a valuable resource to aid in predicting drug sensitivity, to understand therapeutic resistance mechanisms and to identify optimal combination treatment strategies.

6 Nov 2020

Study reveals new therapeutic approach for superbug infections

A research team led by Professor Hongzhe SUN, Chair Professor from the Department of Chemistry, Faculty of Science, in collaboration with Dr Pak-Leung HO, Director of the HKU Carol Yu Centre for Infection from the Department of Microbiology, Li Ka Shing Faculty of Medicine.

5 Nov 2020

Concept of 'wisdom of crowds' can improve decisions about overuse of antibiotics

A new study has demonstrated that using the 'wisdom of crowds' (also known as collective intelligence) of three or more medical prescribers, can improve decisions about antibiotic prescribing and help combat rising levels of antibiotic resistance.

4 Nov 2020

A $200 debit card won’t do much for seniors’ drug costs

If they've been listening to President Donald Trump, seniors may be expecting a $200 debit card in the mail any day now to help them pay for prescription drugs.

30 Oct 2020

Addictive drug displays different acute pharmacology and synaptic plasticity

Nucleus accumbens in the brain play a central role in the risk-reward circuit. Their operation is based chiefly on three essential neurotransmitters: dopamine, which promotes desire; serotonin, whose effects include satiety and inhibition; and glutamate, which drives goal-directed behaviors and responses to reward-associated cues and contexts.

30 Oct 2020

Study shows statins can have adverse effects on certain organs

600,000 Danes take medicine containing statins. Statins lower the cholesterol level and thus helps prevent cardiovascular disease and blood clots.

30 Oct 2020

New method could help increase effectiveness of vaccines against coronavirus

A University at Buffalo-led research team has discovered a technique that could help increase the effectiveness of vaccines against the novel coronavirus, the virus that causes COVID-19.

29 Oct 2020

Exposure to artemisinin drug could increase sexual conversion rate of malaria parasite

Exposure to suboptimal doses of the antiparasitic drug artemisinin could increase the sexual conversion rate of the malaria parasite Plasmodium falciparum, thereby increasing the probability of transmission, according to a study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by "la Caixa" Foundation.

29 Oct 2020

Biophysicists develop computer model that shows effect of antiseptics on bacterial membranes

A team of biophysics from leading Russian research and educational institutions (MSU, RUDN University, and the Federal Research and Clinical Center of the Federal Medical-Biological Agency of Russia) developed a computer model that shows the effect of antiseptics on bacterial membranes.

29 Oct 2020

Study highlights need for safe disposal of opioid drugs during COVID-19 pandemic

During the global coronavirus pandemic, the opioid crisis in the United States "has grown into a much more complicated and deadly drug overdose epidemic," according to a new report by the American Medical Association (AMA).

28 Oct 2020

Pharmaceutical News

New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

FDA releases final guidance to help identify and prevent insanitary conditions at compounders’ facilities

Patients with rheumatic diseases reported antimalarial drug shortages during COVID-19

Hydroxychloroquine not associated with prolonged heart rhythm intervals in RA or lupus patients

Oral methotrexate can be an effective intervention for people with knee OA

TB screening needed for people on methotrexate who live in at-risk areas

Osteoporosis drug increases bone mineral density in the hip and lumbar spine

Commonly prescribed anti-depressant may halt the growth of childhood sarcoma

Researchers develop novel chemo-immunotherapy agent to treat pancreatic tumors

New resource can help predict drug sensitivity and optimize therapeutic strategies

Study reveals new therapeutic approach for superbug infections

Concept of 'wisdom of crowds' can improve decisions about overuse of antibiotics

A $200 debit card won’t do much for seniors’ drug costs

Addictive drug displays different acute pharmacology and synaptic plasticity

Study shows statins can have adverse effects on certain organs

New method could help increase effectiveness of vaccines against coronavirus

Exposure to artemisinin drug could increase sexual conversion rate of malaria parasite

Biophysicists develop computer model that shows effect of antiseptics on bacterial membranes

Study highlights need for safe disposal of opioid drugs during COVID-19 pandemic

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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