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Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

COVID-19 vaccination temporarily alters heart rate variability

HRV parameters after COVID-19 vaccination show significant short-term changes that may persist for up to three days until ultimately returning to baseline.

12 Dec 2022

XBB Omicron variant evades vaccine-induced immunity

A new study published in The Lancet Microbe examines the immune evasion characteristics of the Omicron XBB subvariant.

12 Dec 2022

$Forxiga (dapagliflozin) approved in Great Britain for symptomatic chronic heat failure across the full spectrum of left ventricular ejection fraction$

Forxiga (dapagliflozin) approved in Great Britain for symptomatic chronic heat failure across the full spectrum of left ventricular ejection fraction

AstraZeneca today announced that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted a licence extension for dapagliflozin in Great Britain for the treatment of symptomatic chronic heart failure (HF) in patients with HF and a left ventricular ejection fraction (LVEF) >40%, including HF with mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF).

From AstraZeneca 12 Dec 2022

In rural America, deadly costs of opioids outweigh the dollars tagged to address them

Tim Buck knows by heart how many people died from drug overdoses in his North Carolina county last year: 10. The year before it was 12 — an all-time high.

12 Dec 2022

Intranasal recombinant MVA-based vaccines effective against SARS-CoV-2 variants in mice

Researchers construct a recombinant host-range restricted vaccinia virus Ankara (rMVAs) expressing the spike proteins of several SARS-CoV-2 variants.

11 Dec 2022

Johns Hopkins researchers characterize a broad range of psychedelic occasioned belief changes

Johns Hopkins Medicine researchers continue their exploration into psychedelics and how these drugs may produce a wide range of profound changes in perception, cognition and mood.

9 Dec 2022

Researchers gain new insights into ADHD drug's mechanism of action

For decades, doctors have treated kids with attention-deficit/hyperactivity disorder (ADHD) with methylphenidate, a stimulant drug sold as Ritalin and Concerta, making it one of the most widely prescribed medications aimed at the central nervous system.

8 Dec 2022

Buprenorphine prescription remained constant during the first year of COVID-19 pandemic

The number of active prescriptions for the opioid disorder treatment drug buprenorphine remained constant during the first year of the COVID-19 pandemic, but the number of new prescriptions for the treatment was far below what would normally have been expected, according to a new RAND Corporation study.

7 Dec 2022

Paxlovid has been free so far. Next year, sticker shock awaits.

Nearly 6 million Americans have taken Paxlovid for free, courtesy of the federal government. The Pfizer pill has helped prevent many people infected with covid-19 from being hospitalized or dying, and it may even reduce the risk of developing long covid.

7 Dec 2022

Self-service vending machine filled with harm reduction supplies helps prevent overdoses

More than 107,000 Americans died from drug overdose in 2021, highlighting the need for evidence-based interventions.

6 Dec 2022

COVID-19 vaccination may cause temporary menstrual disturbances in adolescent girls

The Pfizer-BioNTech mRNA-based COVID-19 vaccine may increase the risk of menstrual disturbances in adolescent girls in their first cycle after vaccination.

6 Dec 2022

Higher dose of new antimalarial drug reduces disease recurrence by 85%

A new antimalarial drug is being introduced at a dose that is too low to be effective for all patients who need it, according to a report published today in eLife.

6 Dec 2022

Vaccine MVA-BN shows consistent, robust immunogenicity and safety results

A phase III clinical trial showed consistent immunogenicity for a freeze-dried formulation of Bavarian Nordic's Modified Vaccinia Ankara.

5 Dec 2022

Study examines whether cortisone-like medicine can reduce pain after total knee arthroplasty

Results from a study by Henry Ford Health orthopedic researchers is the latest of several high-powered studies geared toward effectively managing pain and decreasing opioids use after total knee replacement surgery.

5 Dec 2022

Trial shows acoziborole drug clears body of African sleeping sickness parasites

Researchers evaluate the efficacy and safety of an oral antimicrobial drug acoziborole in patients with human African trypanosomiasis.

4 Dec 2022

The business of clinical trials is booming. Private equity has taken notice.

After finding success investing in the more obviously lucrative corners of American medicine — like surgery centers and dermatology practices — private equity firms have moved aggressively into the industry's more hidden niches: They are pouring billions into the business of clinical drug trials.

2 Dec 2022

Gargling with povidone-iodine may reduce salivary viral load in COVID-19 patients

A prospective, randomized, open-level clinical trial demonstrates that gargling with povidone-iodine accelerates viral clearance and reduces saliva infectivity in patients with asymptomatic or mild coronavirus disease 2019 (COVID-19). The trial findings have been published in the journal Scientific Reports.

1 Dec 2022

Study compares the performance of two most popular AMD drugs

A pilot, "look-back" study of information about 106 patients with "wet" age-related macular degeneration (AMD) treated at the Wilmer Eye Institute at Johns Hopkins Medicine has revealed that nearly half of patients treated with aflibercept could safely stop eye injection therapy after one year without further vision loss.

30 Nov 2022

Existing drug may help decrease side effects of widely used cancer treatment

A Michigan State University researcher is part of an international team that found an existing drug may help decrease side effects of cisplatin, a widely used cancer treatment that was discovered at MSU in 1965.

30 Nov 2022

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Pharmaceutical News

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

COVID-19 vaccination temporarily alters heart rate variability

XBB Omicron variant evades vaccine-induced immunity

Forxiga (dapagliflozin) approved in Great Britain for symptomatic chronic heat failure across the full spectrum of left ventricular ejection fraction

In rural America, deadly costs of opioids outweigh the dollars tagged to address them

Intranasal recombinant MVA-based vaccines effective against SARS-CoV-2 variants in mice

Johns Hopkins researchers characterize a broad range of psychedelic occasioned belief changes

Researchers gain new insights into ADHD drug's mechanism of action

Buprenorphine prescription remained constant during the first year of COVID-19 pandemic

Paxlovid has been free so far. Next year, sticker shock awaits.

Self-service vending machine filled with harm reduction supplies helps prevent overdoses

COVID-19 vaccination may cause temporary menstrual disturbances in adolescent girls

Higher dose of new antimalarial drug reduces disease recurrence by 85%

Vaccine MVA-BN shows consistent, robust immunogenicity and safety results

Study examines whether cortisone-like medicine can reduce pain after total knee arthroplasty

Trial shows acoziborole drug clears body of African sleeping sickness parasites

The business of clinical trials is booming. Private equity has taken notice.

Gargling with povidone-iodine may reduce salivary viral load in COVID-19 patients

Study compares the performance of two most popular AMD drugs

Existing drug may help decrease side effects of widely used cancer treatment

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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