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Trial shows acoziborole drug clears body of African sleeping sickness parasites

Researchers evaluate the efficacy and safety of an oral antimicrobial drug acoziborole in patients with human African trypanosomiasis.

4 Dec 2022

The business of clinical trials is booming. Private equity has taken notice.

After finding success investing in the more obviously lucrative corners of American medicine — like surgery centers and dermatology practices — private equity firms have moved aggressively into the industry's more hidden niches: They are pouring billions into the business of clinical drug trials.

2 Dec 2022

Gargling with povidone-iodine may reduce salivary viral load in COVID-19 patients

A prospective, randomized, open-level clinical trial demonstrates that gargling with povidone-iodine accelerates viral clearance and reduces saliva infectivity in patients with asymptomatic or mild coronavirus disease 2019 (COVID-19). The trial findings have been published in the journal Scientific Reports.

1 Dec 2022

Study compares the performance of two most popular AMD drugs

A pilot, "look-back" study of information about 106 patients with "wet" age-related macular degeneration (AMD) treated at the Wilmer Eye Institute at Johns Hopkins Medicine has revealed that nearly half of patients treated with aflibercept could safely stop eye injection therapy after one year without further vision loss.

30 Nov 2022

Existing drug may help decrease side effects of widely used cancer treatment

A Michigan State University researcher is part of an international team that found an existing drug may help decrease side effects of cisplatin, a widely used cancer treatment that was discovered at MSU in 1965.

30 Nov 2022

Cannabidiol and the shifting perspective of epilepsy drug discovery

Researchers discuss the research hat contributed to cannabidiol as a potential antiseizure medication in the 21st century.

29 Nov 2022

Benzodiazepine-related beliefs may influence clinicians' willingness to prescribe the drug

Despite the continuing growth of benzodiazepine (BZD)-related overdoses, BZD prescription rates have held constant.

29 Nov 2022

Large COVID vaccination study found that thrombosis and thrombocytopenia are very rare complications

Researchers determine the rates of thrombosis, thrombocytopenia, and thrombosis with thrombocytopenia following COVID-19 vaccination and infection.

28 Nov 2022

Could mRNA vaccines triumph over other viral infections in humans and domestic animals?

Researchers review potential areas for mRNA vaccine development against pathogenic viruses other than SARS-CoV-2.

28 Nov 2022

COVID-19 lockdown did not cause a mass surge in dispensing of opioids, study finds

While some feared that New Yorkers would re-fill prescriptions to stockpile opioid medications in the early weeks of the COVID-19 lockdown much in the way people hoarded toilet paper, in fact, New York State opioid prescriptions declined in the period around the March 20, 2020 "PAUSE" order, according to new research.

28 Nov 2022

Are nasal-spray vaccines the solution to respiratory infectious diseases?

A recent study published in the journal Trends in Molecular Medicine reviewed the current efforts in developing nasal vaccines, delivery systems, and clinical applications for preventing respiratory illnesses.

28 Nov 2022

Nanoparticles displaying SARS-CoV-1 and SARS-CoV-2 spikes induce broad antibody responses in animal model

A recent study published in the journal iScience reported that nanoparticles (NPs) co-displaying spike proteins from different sarbecoviruses improve the breadth of neutralizing responses.

27 Nov 2022

The potential of Sofosbuvir against COVID-19 neurological symptoms

Researchers discuss how SARS-CoV-2 infects cortical neurons and damages their synapses that form the connection between brain cells.

25 Nov 2022

Study aims to develop broad-spectrum antivirals against SARS-CoV-2 via drug repurposing strategies

This study aims to determine which FDA-approved compound(s) can be repurposed as a broad-spectrum antiviral drug(s) against SARS-CoV-2 and variants.

24 Nov 2022

Young people treated for sleep disorders with benzodiazepines may be at higher risk of overdose

Teens and young adults who are treated for sleep disorders with benzodiazepines such as Xanax – a medication commonly prescribed to treat anxiety and insomnia – may be at a higher risk of overdose, according to Rutgers researchers.

23 Nov 2022

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

In a recent study posted to the bioRxiv* preprint server, researchers in China demonstrated the efficacy of three messenger ribonucleic acid (mRNA) technology-based Monkeypox virus (MPXV) vaccines in combating a lethal Vaccinia virus (VACV) challenge in mice models.

22 Nov 2022

Plant-based monoclonal antibody increases potency of antibody cocktail against SARS-CoV-2 Omicron variant

A novel mAb against the SARS-CoV-2 RBD through a hybridoma technique, followed by chimerization and expression in plants.

22 Nov 2022

Study finds no benefits from angiotensin receptor blocker treatment for COVID-19

In a recent study published in the BMJ, researchers conducted a phase three, multicenter, randomized controlled trial to evaluate the effect of using angiotensin receptor blockers that disrupt the renin-angiotensin system on the clinical outcomes of individuals with coronavirus disease 2019 (COVID-19).

21 Nov 2022

Additional mRNA COVID vaccine doses could salvage antibody responses in blood cancer patients

A third COVID-19 vaccine dose in this patients with blood cancers could enhance their antibody responses against SARS-CoV-2

21 Nov 2022

Comprehensive analysis outlines the potential toxicities of antibody drug conjugates

Over the past two decades, numerous complex cancer therapies called antibody drug conjugates (ADCs) have been tested in clinical trials and approved for use in patients.

21 Nov 2022

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Pharmaceutical News

Trial shows acoziborole drug clears body of African sleeping sickness parasites

The business of clinical trials is booming. Private equity has taken notice.

Gargling with povidone-iodine may reduce salivary viral load in COVID-19 patients

Study compares the performance of two most popular AMD drugs

Existing drug may help decrease side effects of widely used cancer treatment

Cannabidiol and the shifting perspective of epilepsy drug discovery

Benzodiazepine-related beliefs may influence clinicians' willingness to prescribe the drug

Large COVID vaccination study found that thrombosis and thrombocytopenia are very rare complications

Could mRNA vaccines triumph over other viral infections in humans and domestic animals?

COVID-19 lockdown did not cause a mass surge in dispensing of opioids, study finds

Are nasal-spray vaccines the solution to respiratory infectious diseases?

Nanoparticles displaying SARS-CoV-1 and SARS-CoV-2 spikes induce broad antibody responses in animal model

The potential of Sofosbuvir against COVID-19 neurological symptoms

Study aims to develop broad-spectrum antivirals against SARS-CoV-2 via drug repurposing strategies

Young people treated for sleep disorders with benzodiazepines may be at higher risk of overdose

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

Plant-based monoclonal antibody increases potency of antibody cocktail against SARS-CoV-2 Omicron variant

Study finds no benefits from angiotensin receptor blocker treatment for COVID-19

Additional mRNA COVID vaccine doses could salvage antibody responses in blood cancer patients

Comprehensive analysis outlines the potential toxicities of antibody drug conjugates

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