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The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

Researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit AlphaFold2 for antibiotic discovery better.

9 Sep 2022

All SARS-CoV-2 variants neutralized by a potent new antibody

Researchers describe a mouse model used to generate a VH1-2 heavy chain (HC)- and Vκ1-33 light chain (LC)-based recombinant antibody that broadly neutralized all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the newly emergent Omicron sub-variant BA.5.

9 Sep 2022

Licorice compounds proposed as effective candidates for treatment of COVID-19

Researchers describe the different mechanisms by which licorice active ingredients target SARS-CoV-2.

8 Sep 2022

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

New tool uses artificial intelligence to calculate harmful effects of medicines

Research led by the University of Exeter and Kent and Medway NHS and Social Care Partnership Trust, published in Age and Ageing, assessed a new tool designed to calculate which medicines are more likely to experience adverse anticholinergic effects on the body and brain.

7 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

Inhaled glucocorticoids linked to changes in brain matter

A recent BMJ Open study conducted a cross-sectional analysis to test the hypothesis that the usage of systemic and inhaled glucocorticoids was associated with alterations in grey matter volume (GMV) and white matter microstructure.

5 Sep 2022

Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak

A new study published in the Viruses journal aimed to investigate the cross-reactivity of VACV-based vaccines against the MPXV viruses responsible for the 2022 outbreak.

5 Sep 2022

MOO can alleviate depression via increasing 5-HTP in the gut microbiota, study reveals

Announcing a new article publication from Acta Pharmaceutica Sinica B. Morinda officinalis oligosaccharides(MOO) is an oral drug approved in China for the treatment of depression in China.

5 Sep 2022

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Announcing a new article publication from Acta Pharmaceutica Sinica B. The brain is the most advanced organ with various complex structural and functional microregions.

5 Sep 2022

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

A new study determines the antiviral efficacy of favipiravir against ZIKV and SARS-CoV-2 infections.

4 Sep 2022

Cannabis legalization likely to reduce conventional pharmaceutical sales by billions of dollars

Researchers from California Polytechnic State University and The University of New Mexico find that stock market investors predict cannabis legalization will reduce conventional pharmaceutical sales by billions of dollars.

2 Sep 2022

Globalization and cessation of smallpox vaccination are influencing monkeypox spread

A recent review by Barbara S. Schnierle of the Paul-Ehrlich-Institut, Germany, and published in the journal Viruses summarized the existing knowledge about MPXV, the disease it causes, and the strategies to curb its spread.

1 Sep 2022

Dolutegravir-based regimen more effective for treating pregnant people with HIV-1

Dolutegravir-based antiretroviral therapies (ART) for HIV-1 are more effective for pregnant people than some other ART regimens commonly used in the U.S. and Europe, according to a study led by Harvard T.H. Chan School of Public Health researchers.

1 Sep 2022

Leukemia drug successfully disrupts HER2-positive brain metastasis in animal studies

In animal studies led by researchers at Duke Cancer Institute, a drug approved to treat leukemia successfully disrupted the ability of HER2-positive breast cancer tumors from colonizing the brain.

30 Aug 2022

Naturally occurring compound possesses antibacterial activity against several microorganisms

University researchers have found a naturally occurring compound, known as hydroquinine, has bacterial killing activity against several microorganisms.

30 Aug 2022

EEG tests reveal fentanyl's effects on the brain

Fentanyl is used to supplement sedation and to relieve severe pain during and after surgery, but it's also one of the deadliest drugs of the opioid epidemic.

30 Aug 2022

Research reveals administration of ineffective COVID-19 treatments after FDA deauthorization

Monoclonal antibodies are laboratory-designed treatments tailor-made to fight specific infections. In early 2021, the U.S. Food & Drug Administration issued emergency use authorization for two monoclonal antibodies (bamlanivimab/etesevimab and casirivimab/imdevimab) for the treatment of mild to moderate COVID-19 in high-risk, non-hospitalized patients.

30 Aug 2022

mRNA COVID boosters are effective against severe Omicron for at least six months

A new study published in the journal JAMA Network Open aimed to analyze the association of the types of vaccine and their combination with the waning of protection against Omicron in residents of Singapore who were aged 30 years and above and had received at least two doses of a COVID vaccine.

30 Aug 2022

Full-dose anticoagulation lowers the risk of blood clotting complications in COVID-19 patients

A clinical trial of patients with COVID-19 led by investigators at the TIMI Study Group at Brigham and Women's Hospital and the Critical Care Cardiology Trials Network has found that full-dose anticoagulation lowers the risk of blood clotting complications compared with standard-dose prophylactic anticoagulation.

29 Aug 2022

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Pharmaceutical News

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

All SARS-CoV-2 variants neutralized by a potent new antibody

Licorice compounds proposed as effective candidates for treatment of COVID-19

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

New tool uses artificial intelligence to calculate harmful effects of medicines

Auranofin inhibits SARS-CoV-2 replication

Inhaled glucocorticoids linked to changes in brain matter

Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak

MOO can alleviate depression via increasing 5-HTP in the gut microbiota, study reveals

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

Cannabis legalization likely to reduce conventional pharmaceutical sales by billions of dollars

Globalization and cessation of smallpox vaccination are influencing monkeypox spread

Dolutegravir-based regimen more effective for treating pregnant people with HIV-1

Leukemia drug successfully disrupts HER2-positive brain metastasis in animal studies

Naturally occurring compound possesses antibacterial activity against several microorganisms

EEG tests reveal fentanyl's effects on the brain

Research reveals administration of ineffective COVID-19 treatments after FDA deauthorization

mRNA COVID boosters are effective against severe Omicron for at least six months

Full-dose anticoagulation lowers the risk of blood clotting complications in COVID-19 patients

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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