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N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers in the United States demonstrated the efficacy of a novel biopolymer, N-dihydrogalactochitosan (GC), as an adjuvant for next-generation mucosal coronavirus disease 2019 (COVID-19) vaccine.

12 Sep 2022

COVID-19 drugs persist through wastewater treatment, may negatively affect aquatic organisms

Certain drugs used to treat COVID-19 patients - including remdesivir, dexamethasone and antibiotics for associated bacterial infections - persist through wastewater treatment and may occur in waterways at levels high enough to negatively affect aquatic organisms, according to a new study led by researchers at Penn State.

12 Sep 2022

Self-replicating intradermal RNA vaccine against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers assessed the efficiency of a controllable self-replicating ribonucleic acid (c-srRNA) vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

12 Sep 2022

A direct side-by-side comparison of all available COVID-19 vaccines

In a recent study posted to the medRxiv* preprint server, researchers assessed immune responses to homologous and heterologous coronavirus disease 2019 (COVID-19) vaccine combinations among Córdoba, Spain residents.

11 Sep 2022

A new monkeypox vaccine is needed to prevent global transmission

In a recent study published in the journal Vaccines, scientists reviewed all relevant literature to find the available vaccines and therapeutics to prevent MPV.

11 Sep 2022

HKUMed team estimates a moderate link between antipsychotic use and breast cancer by over 30%

A research team from the Centre for Safe Medication Practice and Research (CSMPR), Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) conducted the world's first systematic review and meta-analysis of observational studies with over two million individuals and estimated a moderate association between antipsychotic use and breast cancer by over 30%.

9 Sep 2022

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

Researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit AlphaFold2 for antibiotic discovery better.

9 Sep 2022

All SARS-CoV-2 variants neutralized by a potent new antibody

Researchers describe a mouse model used to generate a VH1-2 heavy chain (HC)- and Vκ1-33 light chain (LC)-based recombinant antibody that broadly neutralized all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the newly emergent Omicron sub-variant BA.5.

9 Sep 2022

Licorice compounds proposed as effective candidates for treatment of COVID-19

Researchers describe the different mechanisms by which licorice active ingredients target SARS-CoV-2.

8 Sep 2022

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

New tool uses artificial intelligence to calculate harmful effects of medicines

Research led by the University of Exeter and Kent and Medway NHS and Social Care Partnership Trust, published in Age and Ageing, assessed a new tool designed to calculate which medicines are more likely to experience adverse anticholinergic effects on the body and brain.

7 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

Inhaled glucocorticoids linked to changes in brain matter

A recent BMJ Open study conducted a cross-sectional analysis to test the hypothesis that the usage of systemic and inhaled glucocorticoids was associated with alterations in grey matter volume (GMV) and white matter microstructure.

5 Sep 2022

Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak

A new study published in the Viruses journal aimed to investigate the cross-reactivity of VACV-based vaccines against the MPXV viruses responsible for the 2022 outbreak.

5 Sep 2022

MOO can alleviate depression via increasing 5-HTP in the gut microbiota, study reveals

Announcing a new article publication from Acta Pharmaceutica Sinica B. Morinda officinalis oligosaccharides(MOO) is an oral drug approved in China for the treatment of depression in China.

5 Sep 2022

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Announcing a new article publication from Acta Pharmaceutica Sinica B. The brain is the most advanced organ with various complex structural and functional microregions.

5 Sep 2022

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

A new study determines the antiviral efficacy of favipiravir against ZIKV and SARS-CoV-2 infections.

4 Sep 2022

Cannabis legalization likely to reduce conventional pharmaceutical sales by billions of dollars

Researchers from California Polytechnic State University and The University of New Mexico find that stock market investors predict cannabis legalization will reduce conventional pharmaceutical sales by billions of dollars.

2 Sep 2022

Globalization and cessation of smallpox vaccination are influencing monkeypox spread

A recent review by Barbara S. Schnierle of the Paul-Ehrlich-Institut, Germany, and published in the journal Viruses summarized the existing knowledge about MPXV, the disease it causes, and the strategies to curb its spread.

1 Sep 2022

Dolutegravir-based regimen more effective for treating pregnant people with HIV-1

Dolutegravir-based antiretroviral therapies (ART) for HIV-1 are more effective for pregnant people than some other ART regimens commonly used in the U.S. and Europe, according to a study led by Harvard T.H. Chan School of Public Health researchers.

1 Sep 2022

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Pharmaceutical News

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

COVID-19 drugs persist through wastewater treatment, may negatively affect aquatic organisms

Self-replicating intradermal RNA vaccine against SARS-CoV-2

A direct side-by-side comparison of all available COVID-19 vaccines

A new monkeypox vaccine is needed to prevent global transmission

HKUMed team estimates a moderate link between antipsychotic use and breast cancer by over 30%

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

All SARS-CoV-2 variants neutralized by a potent new antibody

Licorice compounds proposed as effective candidates for treatment of COVID-19

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

New tool uses artificial intelligence to calculate harmful effects of medicines

Auranofin inhibits SARS-CoV-2 replication

Inhaled glucocorticoids linked to changes in brain matter

Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak

MOO can alleviate depression via increasing 5-HTP in the gut microbiota, study reveals

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

Cannabis legalization likely to reduce conventional pharmaceutical sales by billions of dollars

Globalization and cessation of smallpox vaccination are influencing monkeypox spread

Dolutegravir-based regimen more effective for treating pregnant people with HIV-1

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