Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Two statistically significant genetic variants may be linked to increased PTSD risk in veterans

In a massive analysis of DNA samples from more than 13,000 U.S. soldiers, scientists have identified two statistically significant genetic variants that may be associated with an increased risk of post-traumatic stress disorder (PTSD), an often serious mental illness linked to earlier exposure to a traumatic event, such as combat and an act of violence.

12 May 2016

New BSR report sets roadmap to enhance care for individuals with rare rheumatic and musculoskeletal conditions

The British Society for Rheumatology has today launched a report setting out a programme of work to enhance care for people with rare rheumatic and musculoskeletal conditions.

11 May 2016

TSRI scientists design potential drug candidate to treat triple negative breast cancer

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers—triple negative breast cancer.

10 May 2016

Cancer may have negative impact on health of individuals as they age

A new study indicates that cancer may have negative impacts on both the physical and mental health of individuals as they age. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study suggests that cancer increases the risk for certain health issues above and beyond normal aging. This is likely due, in part, to decreased physical activity and stress associated with cancer diagnosis and treatment.

9 May 2016

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

A major type of inflammatory bowel disease (IBD) may be caused in part by genetic variants that prevent beneficial bacteria in the gut from doing their job, according to a new study published today in the journal Science.

6 May 2016

Study sheds light on development of ILCs that play vital role in body's immune defense

Through the use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases have found that the development of immune cells, called innate lymphoid cells (ILCs), gradually prepares these cells for rapid response to infection. This work, which appeared online today in Cell, sheds light on the development and function of a cell type that is increasingly recognized as having an important role in the body's immune defense. NIAMS is part of the National Institutes of Health.

6 May 2016

New 3D-printed talus replacement surgery to treat avascular necrosis provides life-changing experience

The talus is the part ankle that allows the foot to move in all different directions. High impact injuries like falls, or traffic accidents can cause the talus bone to be fractured, and a high percentage of these injuries result in avascular necrosis (AVN)—the death of the bone. In a first-of-its-kind procedure using 3D printing technology, internationally renowned orthopedic surgeon Dr. Mark Myerson, Director, The Institute for Foot and Ankle Reconstruction at Mercy Medical Center, explains how a talus replacement, tailored to the patient's specific dimensions, can result in a "life-changing experience" for the patient.

4 May 2016

Diabetes risk linked to increased dosage, duration and timing of steroids

Glucocorticoid (or steroid) therapy, prescribed to around half of patients with rheumatoid arthritis, is a known risk factor for developing diabetes. A study from The University of Manchester has found how the risk of diabetes increases in relation to the dosage, duration and timing of steroids.

4 May 2016

Study finds link between placenta and offspring bone

Researchers at the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, studied 518 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) who underwent bone scans at nine, 15 and 17 years old. Measurements such as thickness, volume and weight, were also taken from the mothers' placenta.

4 May 2016

Study identifies shortfall in uptake of influenza, pneumococcal vaccination among RA patients

Research from The University of Manchester has found a shortfall in the uptake of influenza and pneumococcal vaccinations among those diagnosed with rheumatoid arthritis (RA), potentially increasing their infection risk.

3 May 2016

Study shows impact of increasing number of opioid-related hospitalizations on health care costs

Infection is a serious complication of intravenous drug abuse and a major cause of illness and death among intravenous drug users. As the national problem of opioid abuse, including of heroin, continues to grow, new research by clinicians at Beth Israel Deaconess Medical Center and the VA Boston Healthcare System, published today in the May issue of the journal Health Affairs, offers new insights into the significant impact of the trend on opioid-related hospitalizations, infectious complications and health care costs.

3 May 2016

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

3 May 2016

Researchers one step closer to understanding disease origin

Researchers are one step closer to understanding the genetic and biological basis of diseases like cancer, diabetes, Alzheimer's and rheumatoid arthritis - and identifying new drug targets and therapies - thanks to work by three computational biology research teams from the University of Arizona Health Sciences, University of Pennsylvania and Vanderbilt University.

30 Apr 2016

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

29 Apr 2016

People diagnosed with psoriatic arthritis often left with little or no support for emotional problems

In a new University of Manchester study, people with psoriatic arthritis have told researchers about the condition's deeply damaging mental effects and how healthcare services failed to prepare them for its reality.

29 Apr 2016

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to a collaboration between the Perelman School of Medicine at the University of Pennsylvania, the University of Arizona Health Sciences, and Vanderbilt University. The group published their findings this month in npj Genomic Medicine.

29 Apr 2016

TSRI study reveals important traits in LCMV, Lassa virus

For the first time, scientists at The Scripps Research Institute (TSRI) have solved the structure of the biological machinery used by a common virus to recognize and attack human host cells.

27 Apr 2016

Study shows canine AD shares significant features of human version

Atopic dermatitis (AD), a chronic inflammatory skin condition and the most common form of eczema, is estimated to afflict as much as 10 percent of the U.S. population, and is much more common now than it was 50 years ago. Veterinary clinical estimates also show that approximately 10 percent of dogs have atopic dermatitis.

26 Apr 2016

RA patients more likely to experience hearing loss

RA is the commonest autoimmune arthritis affecting 1% of the general population. Despite its main articular manifestations, RA caninvolveextra-articular organs including the auditory system.

25 Apr 2016

Wellderly study finds link between cognitive decline genes and healthy aging

An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or "Wellderly," has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translational Science Institute (STSI) reported today in the journal Cell.

22 Apr 2016

Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Two statistically significant genetic variants may be linked to increased PTSD risk in veterans

New BSR report sets roadmap to enhance care for individuals with rare rheumatic and musculoskeletal conditions

TSRI scientists design potential drug candidate to treat triple negative breast cancer

Cancer may have negative impact on health of individuals as they age

Genetic variations that prevent beneficial gut bacteria from working may lead to Crohn's disease

Study sheds light on development of ILCs that play vital role in body's immune defense

New 3D-printed talus replacement surgery to treat avascular necrosis provides life-changing experience

Diabetes risk linked to increased dosage, duration and timing of steroids

Study finds link between placenta and offspring bone

Study identifies shortfall in uptake of influenza, pneumococcal vaccination among RA patients

Study shows impact of increasing number of opioid-related hospitalizations on health care costs

LJI study could provide important target for autoimmune disease interventions

Researchers one step closer to understanding disease origin

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

People diagnosed with psoriatic arthritis often left with little or no support for emotional problems

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

TSRI study reveals important traits in LCMV, Lassa virus

Study shows canine AD shares significant features of human version

RA patients more likely to experience hearing loss

Wellderly study finds link between cognitive decline genes and healthy aging

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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