Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Researchers clarify the mechanism by which drugs like Celebrex and Vioxx cause heart problems

Researchers at the University of Pennsylvania School of Medicine have clarified the mechanism by which drugs like Celebrex and Vioxx cause heart problems, in multiple animal models.

18 Apr 2006

217 new targets for anti-cancer drugs

By identifying novel genes critical to cancer progression, biologists at the U.S. Department of Energy's Argonne National Laboratory have expanded the number of drug targets researchers have available for study to find ways to stop tumors in their tracks.

18 Apr 2006

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.

16 Apr 2006

First evidence that circulating endothelial microparticles lead to heart valve disease

Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium - the cells that line the inside of blood vessels and some organs -and appear to cause no problems.

13 Apr 2006

IL-25 both promotes and limits inflammatory diseases

The same signal responsible for promoting the type of immune responses that cause asthma and allergy can also limit the type of inflammation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers from the University of Pennsylvania School of Veterinary Medicine.

13 Apr 2006

Study assesses formularies across Medicare drug plans

Medicare's new private stand-alone drug plans vary significantly - in terms of covered drugs, out-of-pocket costs for specific medications, and restrictions placed on the use of certain drugs - according to a new analysis released today by the Kaiser Family Foundation.

11 Apr 2006

Lubricin research points to future therapies for osteoarthritis

New evidence to explain how the body's natural joint lubricant prevents the wear and tear that can lead to osteoarthritis has been uncovered by researchers at Duke University's Pratt School of Engineering.The findings may lead to new methods for treating arthritis, the researchers said.

11 Apr 2006

Alcohol use, comorbidity, and mortality

Older men who drink as few as two drinks twice a week and also have diseases that could be worsened by alcohol or cause problems with medications taken while drinking alcohol have higher death rates, as compared to men who either drink less or may drink more but don't have such comorbidities.

11 Apr 2006

Study illustrates contribution of obesity to decreased mobility in high functioning older women with osteoarthritis

Osteoarthritis, common among older adults, is strongly linked to late-life disability, but the process by which this happens has not been well studied.

11 Apr 2006

Drug trial disaster will discourage future volunteers

According to the British government agency responsible for medical safety, the Medicines and Healthcare Products Regulatory Agency (MHRA), no evidence has been found to suggest there were any problems with the manufacturing of a drug which left six volunteers seriously ill.

6 Apr 2006

MIT look at how cells make life-or-death decisions

The biological processes underlying diseases such as rheumatoid arthritis and cancer are fundamentally linked, and should be linked in how they are treated with drugs, a series of MIT studies indicates.

6 Apr 2006

Inflammation cuts both ways

Inflammation cuts both ways. When invaded by an infectious agent, for example, the body calls on the forces of inflammation to fight and defeat the intruder.

6 Apr 2006

Celebrex appears to prevent colon cancer

Researchers say they have found that high doses of the arthritis drug Celebrex reduced the number of pre-cancerous growths in the colon.

4 Apr 2006

Quality of care provided for elderly osteoarthritic patients needs improvement

Osteoarthritis is a debilitating disease affecting up to 80% of elderly adults. Among those living on their own, it is the leading cause of an inability to engage in daily activities, especially if the knee or hip is affected.

4 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Inflammation, cartilage and bone erosions, joint destruction--that's the typical progression of arthritis and most rheumatic diseases.

4 Apr 2006

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Vascular endothelial cells (VECs) form the walls of blood vessels and play a critical role in inflammation.

4 Apr 2006

Mustard and garlic kick linked to single pain receptor

A single pain receptor is solely responsible for the kick delivered by mustard oil and garlic, according to research in the Cell. Mustard oil is the active ingredient in mustard and in the pungent green sushi condiment known as wasabi.

28 Mar 2006

Remicade (infliximab) gains Australian approval for treatment of early rheumatoid arthritis

Schering-Plough Corporation today announced that the Therapeutic Goods Administration of the Department of Health and Ageing in Australia has revised the indication of Remicade (infliximab) to include the treatment of early rheumatoid arthritis (RA) and approved a new indication for psoriatic arthritis (PsA).

23 Mar 2006

Stem cells, gene therapy and allograft applications show promise for treating orthopaedic conditions

Recent advances in gene therapy, stem cells and other promising applications are offering new hope for patients and helping orthopaedic surgeons provide state-of-the-art treatment for various frame-related conditions.

23 Mar 2006

Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

Researchers clarify the mechanism by which drugs like Celebrex and Vioxx cause heart problems

217 new targets for anti-cancer drugs

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

First evidence that circulating endothelial microparticles lead to heart valve disease

IL-25 both promotes and limits inflammatory diseases

Study assesses formularies across Medicare drug plans

Lubricin research points to future therapies for osteoarthritis

Alcohol use, comorbidity, and mortality

Study illustrates contribution of obesity to decreased mobility in high functioning older women with osteoarthritis

Drug trial disaster will discourage future volunteers

MIT look at how cells make life-or-death decisions

Inflammation cuts both ways

Celebrex appears to prevent colon cancer

Quality of care provided for elderly osteoarthritic patients needs improvement

Targeting the inflamed synovium: The quest for specificity

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Mustard and garlic kick linked to single pain receptor

Remicade (infliximab) gains Australian approval for treatment of early rheumatoid arthritis

Stem cells, gene therapy and allograft applications show promise for treating orthopaedic conditions

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

Arthritis & Rheumatology News and Research

Latest Arthritis & Rheumatology News and Research

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

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