Chromosome News and Research

Latest Chromosome News and Research

Researchers study how cancer cells re-organize 3D structure of DNA to ramp up oncogene activity

In cancer, a lot of biology goes awry: Genes mutate, molecular processes change dramatically, and cells proliferate uncontrollably to form entirely new tissues that we call tumors.

10 May 2021

Researchers show SARS-CoV-2 genes can be integrated into the human genome

Researchers in the United States have shown that genes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – can be integrated into the genome of infected human cells.

10 May 2021

New method shows that tau forms small aggregates as part of the body's normal physiology

It turns out that not all build-ups of tau protein are bad, and a team of researchers from the Perelman School of Medicine at the University of Pennsylvania developed a method to show that.

6 May 2021

Researchers report rare case of cardiac arrhythmias in a neonate with Turner syndrome

Doctors treating babies born with Turner syndrome need to look for heart rhythm abnormalities, in addition to the usual heart problems of high blood pressure or left-sided structural heart defects, according to Meena Bolourchi, MD, assistant professor of pediatrics at Boston University School of Medicine.

30 Apr 2021

High-powered MRI detects subtle differences in the hippocampus of people with Down syndrome

Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus--a region of the brain tied to memory and learning.

29 Apr 2021

Researchers apply 'kitchen sink approach' to produce 16 high-quality reference genomes

The flightless kakapo of New Zealand is in trouble. The world's heaviest parrot--representing one of the most ancestral branches of the parrot family tree--is nearly extinct, with barely 200 adults plodding the underbrush of four small islands.

29 Apr 2021

Researchers try to simplify gene nomenclature across various organisms

Constantina Theofanopoulou wanted to study oxytocin. Her graduate work had focused on how the hormone influences human speech development, and now she was preparing to use those findings to investigate how songbirds learn to sing. The problem was that birds do not have oxytocin. Or so she was told.

29 Apr 2021

Marmoset study establishes standards for the new era of biodiversity genomics

The international consortium today announces a series of publications in a special collection of Nature that resulted from the first phase of the Vertebrate Genome Project (VGP) to release 16 high quality reference genomes.

29 Apr 2021

Researchers identify genetic abnormalities that drive invasiveness in head and neck cancer

A multi-institutional team of researchers has identified both the genetic abnormalities that drive pre-cancer cells into becoming an invasive type of head and neck cancer and patients who are least likely to respond to immunotherapy.

26 Apr 2021

Blood-brain barrier and its effect on the immune system play a role in schizophrenia

Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything that could lead to disease and dangerous inflammation--at least when all is functioning normally.

21 Apr 2021

HP1a is a key epigenetic regulator that maintains chromosome integrity

The information of the human genome is encoded by approximately 3 billion DNA base pairs and packaged into 23 pairs of chromosomes.

16 Apr 2021

New genetic markers may lead to personalized treatments for lung cancer

Investigators at Wake Forest School of Medicine, part of Wake Forest Baptist Health, have identified a set of new genetic markers that could potentially lead to new personalized treatments for lung cancer.

15 Apr 2021

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion.

13 Apr 2021

Aneuploidy testing can be key in determining optimal treatment for lung cancer patients

Patients with non-small cell lung cancer (NSCLC) whose cancer cells have low levels of aneuploidy - an abnormal number of chromosomes - tend to respond better to immune checkpoint inhibitor drugs than patients with higher levels, Dana-Farber Cancer Institute researchers will report at the virtual AACR Annual Meeting 2021.

12 Apr 2021

Asymptomatic SARS-CoV-2 individuals with blood group AB at highest risk

Scientists worldwide are conducting extensive research to understand the nature of the virus, its transmission kinetics, etc. They have found a strong correlation between the ABO blood group and SARS-CoV-2 regarding its morbidity and mortality.

9 Apr 2021

Full assembly of human chromosome 8 reveals novel genes, disease risks

The full assembly of human chromosome 8 is reported this week in Nature. While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing structure and function generally.

8 Apr 2021

Mother's stress levels during conception could be a determinant of fetal sex

A study carried out by scientists from the University of Granada has revealed that women who experience stress both before becoming pregnant and during conception are almost twice as likely to have a girl as a boy.

6 Apr 2021

New genetic link to male infertility found

The findings published in eLife show that men with this unstable subtype of the Y chromosome have a significantly increased risk of genomic rearrangements.

1 Apr 2021

SwRI researchers part of two collaborative teams receive SAMF bioscience grants

Collaborative teams that include Southwest Research Institute staff received two of six recently awarded San Antonio Medical Foundation (SAMF) bioscience grants. SwRI, in collaboration with UT Health San Antonio and University Health System, received a nearly $200,000 grant to develop machine learning algorithms for cancer detection.

31 Mar 2021

Rare genetic variant may explain severe COVID-19 in young healthy male patients

A recent study describes the association of rare alleles in a specific gene with severe COVID-19 in young male patients.

29 Mar 2021

Chromosome News and Research

Latest Chromosome News and Research

Researchers study how cancer cells re-organize 3D structure of DNA to ramp up oncogene activity

Researchers show SARS-CoV-2 genes can be integrated into the human genome

New method shows that tau forms small aggregates as part of the body's normal physiology

Researchers report rare case of cardiac arrhythmias in a neonate with Turner syndrome

High-powered MRI detects subtle differences in the hippocampus of people with Down syndrome

Researchers apply 'kitchen sink approach' to produce 16 high-quality reference genomes

Researchers try to simplify gene nomenclature across various organisms

Marmoset study establishes standards for the new era of biodiversity genomics

Researchers identify genetic abnormalities that drive invasiveness in head and neck cancer

Blood-brain barrier and its effect on the immune system play a role in schizophrenia

HP1a is a key epigenetic regulator that maintains chromosome integrity

New genetic markers may lead to personalized treatments for lung cancer

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Aneuploidy testing can be key in determining optimal treatment for lung cancer patients

Asymptomatic SARS-CoV-2 individuals with blood group AB at highest risk

Full assembly of human chromosome 8 reveals novel genes, disease risks

Mother's stress levels during conception could be a determinant of fetal sex

New genetic link to male infertility found

SwRI researchers part of two collaborative teams receive SAMF bioscience grants

Rare genetic variant may explain severe COVID-19 in young healthy male patients

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Chromosome News and Research

Latest Chromosome News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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