Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Prevention

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Latest Colorectal Cancer News and Research

New research shines light on position-specific hallmarks of cancer

A team led by the Cancer Immunogenomics group at the Josep Carreras Leukaemia Research Institute, the Computational Biology group at the Barcelona Supercomputing Center and the Germans Trias i Pujol Research Institute shows, for the first time, that within a tumor, the expression of the different hallmarks of cancer is not cell-specific, but rather position-specific.

30 Jan 2025

Tracking cfDNA levels may help better evaluate surgery colorectal cancer effectiveness

A new research paper was published in Oncotarget's Volume 16 on January 21, 2025, titled "Assessment of cfDNA release dynamics during colorectal cancer surgery."

27 Jan 2025

Triple therapy shows strong response in BRAF V600E mutant metastatic colorectal cancer

Patients with metastatic colorectal cancer (mCRC) harboring BRAF V600E mutations benefitted from first-line treatment with the targeted therapies encorafenib and cetuximab plus a mFOLFOX6 chemotherapy regimen, according to results from the Phase III BREAKWATER trial led by researchers at The University of Texas MD Anderson Cancer Center.

26 Jan 2025

A global look at the gut: Scientists highlight microbiome diversity

Researchers analyzed 168,464 samples to uncover how geographic and technical factors shape global gut microbiome variation, highlighting underrepresented regions and technical biases.

23 Jan 2025

Study finds anti-correlation of KLRG1 and PD-1 expression in tumor fighting T cells

A new research paper was published in Oncotarget's Volume 16 on January 20, 2025, titled "Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells."

21 Jan 2025

AI uncovers promising biomarkers for early detection of colorectal cancer

Machine learning and artificial intelligence (AI) techniques and analysis of large datasets have helped University of Birmingham researchers to discover proteins that have strong predictive potential for colorectal cancer.

21 Jan 2025

Protein CD74 could predict immunotherapy response in bowel cancer

Researchers at the Francis Crick Institute and Barts Cancer Institute, Queen Mary University of London, have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy.

16 Jan 2025

A new AI tool for unlocking the secrets of spatial multi-omics in cancer

A new artificial intelligence-powered tool called MISO (Multi-modal Spatial Omics) can detect cell-level characteristics of cancer by looking at data from extremely small pieces of tissue-some as small as 400 square micrometers, equivalent to the width of five human hairs.

16 Jan 2025

Mouse protein disrupts cancer-causing epigenetic changes in human colorectal cancer

A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new study from researchers at the Johns Hopkins Kimmel Cancer Center and the Chinese Academy of Sciences.

16 Jan 2025

Panakeia launches AI-driven PANProfiler Colon for rapid cancer profiling

Panakeia (“the Company”), a pioneer in AI-driven multi-omic biomarker profiling, today announces the launch of PANProfiler Colon, an AI-driven software solution for profiling of Microsatellite instability (MSI) and mismatch repair deficiency (dMMR) entirely digitally and directly from Hematoxylin and Eosin (H&E)-stained images of colon cancer tissue samples.

15 Jan 2025

New target identified for potential colorectal cancer treatment

Colorectal cancer (CRC) is a type of cancer that begins in the colon (large intestine) or rectum, which are parts of the digestive system.

15 Jan 2025

Short-chain fatty acids propionate and butyrate directly modify chromatin to regulate gene expression

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer and normal cellular processes.

13 Jan 2025

Medicare Advantage leads to lower cancer drug costs in colorectal cancer

A new study examining the use of high-cost drugs among patients with colorectal cancer and non-small cell lung cancer found those insured through Medicare Advantage received less expensive cancer drugs compared to others on Traditional Medicare.

10 Jan 2025

Machine learning reveals why cancer trials fall short in real-world patients

TrialTranslator uses machine learning to assess cancer RCT generalizability, revealing survival gaps for high-risk patients and enhancing research accuracy.

10 Jan 2025

Dairy products linked to lower colorectal cancer risk, thanks to calcium

This study reveals strong links between calcium intake and reduced colorectal cancer risk, highlighting dietary factors influencing cancer incidence in women.

10 Jan 2025

Targeting miR-4274 and PEX5 can help overcome radioresistance in colorectal cancer

Colorectal cancer (CRC) is a global health concern, and despite advances in radiotherapy, endogenous radioresistance in CRC patients remains a challenge.

9 Jan 2025

Geneoscopy closes $105 M in Series C funding round to power next-generation of gastrointestinal diagnostic tests

Geneoscopy, Inc., a life sciences company focused on developing diagnostic tests for the advancement of gastrointestinal health, today announced the closing of a Series C funding round raising $105 million.

9 Jan 2025

New AI system aims to improve real-world application of clinical trial results

A new study led by Winship Cancer Institute of Emory University and Abramson Cancer Center of University of Pennsylvania researchers demonstrates that a first-of-its-kind platform using artificial intelligence (AI) could help clinicians and patients assess whether and how much an individual patient may benefit from a particular therapy being tested in a clinical trial.

8 Jan 2025

Multidisciplinary Hispanic health study receives $21 million NIH grant

A multidisciplinary team of University of Miami researchers studying factors associated with health outcomes and disease risk in the Hispanic community has received a $21 million grant from the National Institutes of Health (NIH).

7 Jan 2025

Vegan or not, plant-based foods boost gut microbes for better health

Study shows distinct gut microbiome signatures across diets, highlighting the health benefits of plant-based foods and risks of red meat consumption.

7 Jan 2025

Colorectal Cancer

Overview

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Prevention

Feature Articles

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Latest Colorectal Cancer News and Research

New research shines light on position-specific hallmarks of cancer

Tracking cfDNA levels may help better evaluate surgery colorectal cancer effectiveness

Triple therapy shows strong response in BRAF V600E mutant metastatic colorectal cancer

A global look at the gut: Scientists highlight microbiome diversity

Study finds anti-correlation of KLRG1 and PD-1 expression in tumor fighting T cells

AI uncovers promising biomarkers for early detection of colorectal cancer

Protein CD74 could predict immunotherapy response in bowel cancer

A new AI tool for unlocking the secrets of spatial multi-omics in cancer

Mouse protein disrupts cancer-causing epigenetic changes in human colorectal cancer

Panakeia launches AI-driven PANProfiler Colon for rapid cancer profiling

New target identified for potential colorectal cancer treatment

Short-chain fatty acids propionate and butyrate directly modify chromatin to regulate gene expression

Medicare Advantage leads to lower cancer drug costs in colorectal cancer

Machine learning reveals why cancer trials fall short in real-world patients

Dairy products linked to lower colorectal cancer risk, thanks to calcium

Targeting miR-4274 and PEX5 can help overcome radioresistance in colorectal cancer

Geneoscopy closes $105 M in Series C funding round to power next-generation of gastrointestinal diagnostic tests

New AI system aims to improve real-world application of clinical trial results

Multidisciplinary Hispanic health study receives $21 million NIH grant

Vegan or not, plant-based foods boost gut microbes for better health

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

Colorectal Cancer

Overview

Feature Articles

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Latest Colorectal Cancer News and Research

Innovating for impact: Jordi Labs on aligning methodologies with FDA expectation

Exploring the role of confocal-based high-content imaging in advancing core facilities

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

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