Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Prevention

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Latest Colorectal Cancer News and Research

New guidelines for optimizing bowel preparation in colonoscopy procedures

Updated consensus recommendations by the U.S. Multi-Society Task Force on Colorectal Cancer (MSTFCRC) address optimizing the quality of bowel preparation for colonoscopy.

5 Mar 2025

Co-occurring mutations may limit effectiveness of KRAS G12C inhibitors in colorectal and pancreatic cancer

Colorectal cancer and pancreatic ductal adenocarcinoma that harbored the KRAS G12C mutation often carried other genetic alterations that can be associated with resistance to KRAS G12C inhibitors, despite no prior treatment with this therapy, according to recent results from a large multidatabase analysis.

3 Mar 2025

AI detects colorectal cancer with high accuracy

A new AI-based tool for identifying colorectal cancer from tissue sample analysis has been developed at the University of Jyväskylä. The new artificial neural network model has surpassed all its predecessors in classification performance. The tool has also been made freely available.

28 Feb 2025

Study unravels the link between colorectal cancer risk and steatotic liver disease

Alcoholic and non-alcoholic fatty liver disease (NAFLD) are well-known risk factors for colorectal cancer (CRC).

27 Feb 2025

Lipid signatures could guide personalized treatment for colorectal cancer

Colorectal cancer, the second most common cause of cancer-related death, affects almost 2 million people worldwide every year.

26 Feb 2025

Study finds key p53 targets for future cancer treatment

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells."

24 Feb 2025

New photosensitizer shows promise in treating colorectal cancer

Colorectal cancer (CRC) is a highly malignant disease that readily metastasizes to vital organs. Many strategies have been employed for clinical CRC therapy.

22 Feb 2025

New 3D tissue imaging technique enhances thyroid tumor analysis

Empa researchers have developed a new 3D tissue analysis for thyroid tumors. This special X-ray technique uses artificial intelligence to enable faster and more precise diagnoses.

21 Feb 2025

Unfolded protein response disruptions contribute to colorectal cancer and gut-related disorders

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

20 Feb 2025

Preventing colorectal cancer through lifestyle choices

The evidence is clear - screening for colorectal cancer may save one's life. Today, more and more people are choosing colorectal cancer screening. As a result, there is a steady decline in the number of older people getting and dying from colorectal cancer. Lower rates of smoking among Americans have also contributed to the decline in the past several years.

19 Feb 2025

Milk boosts gut-friendly bacteria while cheese alters microbiome balance, study reveals

Researchers found that dairy consumption influences gut microbiota composition, with milk promoting beneficial bacteria and cheese altering microbial diversity in distinct ways.

18 Feb 2025

Rethinking red meat: Are dietary guidelines missing the bigger picture?

Research highlights the critical role of red meat in providing essential nutrients like iron, zinc, and B12, particularly for vulnerable populations, while questioning the low-certainty evidence linking it to chronic diseases. It urges policymakers to balance health, environmental, and economic factors when considering dietary guidelines.

13 Feb 2025

Could yogurt help prevent certain colorectal cancers? New study explores the link

Regular yogurt intake may lower the risk of Bifidobacterium-positive colorectal cancer, particularly in the proximal colon, but does not reduce the risk of Bifidobacterium-negative tumors. Further research is needed to confirm these findings and understand yogurt’s role in gut health and cancer prevention.

13 Feb 2025

Oral vancomycin induces PSC-IBD remission, driving gut microbiome and metabolic shifts

Findings indicate oral vancomycin induces remission in PSC-IBD, with notable microbiota changes and inflammation reduction, reversing after treatment ends.

13 Feb 2025

Long-term yogurt intake linked to reduced risk of colorectal cancer

Yogurt, which contains live strains of bacteria, is thought to protect against many types of diseases, with some reports indicating it could reduce risk of colorectal cancer.

12 Feb 2025

KAIST team discovers molecular switch to reverse cancer cells

Professor Kwang-Hyun Cho's research team has recently been highlighted for their work on developing an original technology for cancer reversal treatment that does not kill cancer cells but only changes their characteristics to reverse them to a state similar to normal cells.

6 Feb 2025

New research shines light on position-specific hallmarks of cancer

A team led by the Cancer Immunogenomics group at the Josep Carreras Leukaemia Research Institute, the Computational Biology group at the Barcelona Supercomputing Center and the Germans Trias i Pujol Research Institute shows, for the first time, that within a tumor, the expression of the different hallmarks of cancer is not cell-specific, but rather position-specific.

30 Jan 2025

Tracking cfDNA levels may help better evaluate surgery colorectal cancer effectiveness

A new research paper was published in Oncotarget's Volume 16 on January 21, 2025, titled "Assessment of cfDNA release dynamics during colorectal cancer surgery."

27 Jan 2025

Triple therapy shows strong response in BRAF V600E mutant metastatic colorectal cancer

Patients with metastatic colorectal cancer (mCRC) harboring BRAF V600E mutations benefitted from first-line treatment with the targeted therapies encorafenib and cetuximab plus a mFOLFOX6 chemotherapy regimen, according to results from the Phase III BREAKWATER trial led by researchers at The University of Texas MD Anderson Cancer Center.

26 Jan 2025

A global look at the gut: Scientists highlight microbiome diversity

Researchers analyzed 168,464 samples to uncover how geographic and technical factors shape global gut microbiome variation, highlighting underrepresented regions and technical biases.

23 Jan 2025