Colorectal Cancer News and Research

Latest Colorectal Cancer News and Research

Neogenix Oncology's ensituximab granted FDA orphan drug designation for pancreatic cancer treatment

Neogenix Oncology, Inc. (Neogenix) announced today that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to the company's product candidate ensituximab (monoclonal antibody NPC-1C) for the treatment of pancreatic cancer. The Company initiated in December 2009 a multi-center Phase I clinical trial of ensituximab (NPC-1C) for the treatment of advanced pancreatic and colorectal cancer.

1 Nov 2010

Spectrum submits complete response to FDA's CRL for FUSILEV to treat colorectal cancer

Spectrum Pharmaceuticals, a biotechnology company with fully integrated commercial and drug development operations with a primary focus in oncology, today announced that on Friday, October 29, 2010 it submitted a complete response to the "Complete Response" letter issued by the U.S. Food and Drug Administration (FDA), regarding its supplemental New Drug Application (sNDA) for FUSILEV (levoleucovorin) for Injection for treatment of patients with advanced metastatic colorectal cancer.

1 Nov 2010

Study suggests microRNA binding site helps improved prognosis of colorectal cancer at early stage

A variant site linked to poor outcome in advanced colorectal cancer has now been found to predict improved prognosis in early stages of cancer, according to research presented at the American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held Oct. 27-30, 2010.

29 Oct 2010

Studies identify effective strategies for improving colorectal cancer screening among African-Americans

African-Americans are less likely than whites to be screened for colorectal cancer, and the disparity almost certainly contributes to higher mortality. A new review of studies identifies effective strategies for improving the situation, but suggests that work remains to be done.

29 Oct 2010

Novel small molecule inhibitors may provide new therapy for colon cancer

Researchers are one step closer to providing a new therapy for colon cancer, after findings revealed that a small molecule focal adhesion kinase (FAK) inhibitor known as Y15 effectively blocked cell viability, promoted detachment and apoptosis, and decreased tumor growth in mice. These findings were presented at the American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held Oct. 27-30, 2010.

29 Oct 2010

New approach for early diagnosis of pancreatic cancer

Pancreatic tumors are one of the most lethal cancers, with fewer than five percent of patients surviving five years after diagnosis. But a new study that peers deeply into the genetics of pancreatic cancer presents a bit of good news an opportunity for early diagnosis. In contrast to earlier predictions, many pancreatic tumors are, in fact, slow growing, taking nearly 20 years to become lethal after the first genetic perturbations appear.

29 Oct 2010

Non-invasive stool-based screening test detects 64% of colorectal pre-cancers

Exact Sciences today presented data showing that its non-invasive Cologuard stool-based (sDNA) screening test detected 64 percent of colorectal pre-cancers and 85 percent of cancers. The study was conducted in collaboration with Mayo Clinic and examined more than 1,100 patient samples. Results were presented at the 2010 Special Conference for Colorectal Cancer: Biology to Therapy held by the American Association for Cancer Research in Philadelphia, PA.

29 Oct 2010

Researchers identify small-molecule inhibitors that effectively target FAK enzyme in colon cancer

Researchers have identified two small-molecule inhibitors that effectively targeted the focal adhesion kinase (FAK), an enzyme present in certain cancers that helps tumors thrive and survive.

29 Oct 2010

Researchers develop three-dimensional culture that mimics growth patterns of colon cancer stem cells

University of Pittsburgh researchers have devised a three-dimensional system in laboratory culture that mimics the growth patterns of colon cancer stem cells in patients. Their findings were presented at the American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held Oct. 27-30, 2010.

29 Oct 2010

New noninvasive stool DNA test to predict colorectal cancer

An investigational DNA methylation test could alter the screening landscape for colorectal cancer, according to data presented at the American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held here Oct. 27-30, 2010.

29 Oct 2010

Researchers find link between telomere length and colorectal cancer risk

For the first time, researchers have found a link between long telomeres and an increased risk for colorectal cancer, according to research presented at the American Association for Cancer Research special conference on Colorectal Cancer Biology to Therapy, held here Oct. 27-30, 2010.

29 Oct 2010

Government institutions need to find alternate funding sources for colorectal cancer screening

Offering colorectal cancer screening to poor minority women during mammography visits can effectively expand screening in this otherwise underserved population, although lack of medical insurance remains a significant barrier. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal of the American Cancer Society. The results highlight the need to find alternative funding sources for colorectal cancer screening from the government or private institutions.

28 Oct 2010

Epigenomics presents data on Septin9 biomarker clinical study for colorectal cancer at UEGW

Epigenomics AG, the cancer diagnostics company, announced that new data obtained in a clinical study with the Company's proprietary Septin9 biomarker for the blood-based detection of colorectal cancer, were presented yesterday at the 18th United European Gastroenterology Week (UEGW) in Barcelona, Spain.

28 Oct 2010

£600 million cancer drug fund for UK cancer patients

Good news for cancer patients in England, the government has announced that it would fulfill a pledge to set up a drugs fund. Earlier the Department of Health promised the extra funding after a report revealed the low level of spending in the UK on cancer medication compared to the rest of Europe.

27 Oct 2010

Five ways to prevent bowel cancer: Study

According to the latest research five simple lifestyle changes could cut the risk of bowel cancer by 23%. The Danish study enrolled 57,053 adults aged 50 to 64 without cancer between 1993 and 1997. They were followed up closely for 10 years. Results showed that people who followed public health recommendations (not smoking, a healthier diet, etc.) for each of these areas had a lower risk of developing colorectal cancer during this time.

27 Oct 2010

Exact Sciences 2010 third quarter total revenue increases to $1.4 million from $1.3 million

Exact Sciences Corp. today announced its financial results for the third quarter ended September 30, 2010.

27 Oct 2010

New G-DOC repository for biological information

Georgetown Lombardi Comprehensive Cancer Center, part of Georgetown University Medical Center, announces the launch of the Georgetown Database of Cancer or G-DOC. Under development for two years, G-DOC is a repository for biological information that is normally only available in scattered information libraries and tissue banks, if at all. Data sets grow as researchers deposit new information. G-DOC also contains relevant tools to analyze the data, plus new ones not seen before.

27 Oct 2010

Adherence to lifestyle recommendations reduces risk of colorectal cancer by 23%

Almost a quarter of colorectal (bowel) cancer cases could be prevented if people followed healthy lifestyle advice in five areas including diet and exercise, says a new study published on bmj.com today.

27 Oct 2010

Study finds association between KRAS p.G13D mutations and cetuximab treatment in colorectal cancer

Even though the cancer-treatment agent cetuximab is not considered effective treatment for KRAS (a gene)-mutated metastatic colorectal tumors, new research indicates that patients with colorectal cancer not responding to chemotherapy and a certain variation of this gene who were treated with cetuximab had longer overall and progression-free survival than patients with other KRAS-mutations, according to a study in the October 27 issue of JAMA.

27 Oct 2010

Oncolytics presents REO 013 clinical trial data for colorectal cancer at International Symposium in Spain

Oncolytics Biotech Inc. announced today that interim data from a U.K. translational clinical trial (REO 013) investigating intravenous administration of REOLYSIN in patients with metastatic colorectal cancer prior to surgical resection of liver metastases was presented at the International Symposium on Cytotoxic T-lymphocytes (CTL) and Immunostimulation being held in Pamplona, Spain.

27 Oct 2010

Colorectal Cancer News and Research

Latest Colorectal Cancer News and Research

Neogenix Oncology's ensituximab granted FDA orphan drug designation for pancreatic cancer treatment

Spectrum submits complete response to FDA's CRL for FUSILEV to treat colorectal cancer

Study suggests microRNA binding site helps improved prognosis of colorectal cancer at early stage

Studies identify effective strategies for improving colorectal cancer screening among African-Americans

Novel small molecule inhibitors may provide new therapy for colon cancer

New approach for early diagnosis of pancreatic cancer

Non-invasive stool-based screening test detects 64% of colorectal pre-cancers

Researchers identify small-molecule inhibitors that effectively target FAK enzyme in colon cancer

Researchers develop three-dimensional culture that mimics growth patterns of colon cancer stem cells

New noninvasive stool DNA test to predict colorectal cancer

Researchers find link between telomere length and colorectal cancer risk

Government institutions need to find alternate funding sources for colorectal cancer screening

Epigenomics presents data on Septin9 biomarker clinical study for colorectal cancer at UEGW

£600 million cancer drug fund for UK cancer patients

Five ways to prevent bowel cancer: Study

Exact Sciences 2010 third quarter total revenue increases to $1.4 million from $1.3 million

New G-DOC repository for biological information

Adherence to lifestyle recommendations reduces risk of colorectal cancer by 23%

Study finds association between KRAS p.G13D mutations and cetuximab treatment in colorectal cancer

Oncolytics presents REO 013 clinical trial data for colorectal cancer at International Symposium in Spain

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Colorectal Cancer News and Research

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