Coronary Artery Disease News and Research

Latest Coronary Artery Disease News and Research

Second pivotal Phase 3 trial to evaluate investigational Lp-PLA2 inhibitor darapladib initiated

Attached is a press release issued earlier this morning by GlaxoSmithKline, announcing that GSK has initiated its second pivotal Phase 3 trial to evaluate the efficacy of long-term treatment with the investigational Lp-PLA2 inhibitor darapladib in men and women with acute coronary syndrome (ACS).

10 Dec 2009

TRYTON-LM clinical study enrolls first two patients

Tryton Medical, Inc., the leading developer of stents designed to definitively treat bifurcation lesions, today announced the enrollment of the first two patients in TRYTON-LM, a prospective, single-arm study evaluating the feasibility of the Tryton stent in conjunction with Abbott’s XIENCE PRIME Everolimus Eluting Coronary Stent System to treat stable patients with complex de novo bifurcation lesions involving the left main coronary artery.

9 Dec 2009

Type 2 diabetics with CAD experience greater antiplatelet activity with prasugrel compared to clopidogrel

Results from a new study showed patients with type 2 diabetes who also had coronary artery disease (CAD) experienced greater antiplatelet activity with the investigational antiplatelet drug prasugrel compared to Plavix(R) (clopidogrel). Patients who received a 60 mg loading dose and 10 mg maintenance dose of prasugrel achieved significantly greater platelet inhibition compared with a 600 mg loading dose and 150 mg maintenance dose of Plavix.

4 Dec 2009

Findings suggest severity of atherosclerosis depends on the rate of white blood cell migration

By measuring the total gene activity in organs relevant for coronary artery disease (CAD), scientists at the Swedish medical university Karolinska Institutet have identified a module of genes that is important for the recruitment of white blood cells into the atherosclerotic plaque.

4 Dec 2009

Breastfeeding a child may lower a woman's risk of developing Metabolic Syndrome

Breastfeeding a child may lower a woman's risk of developing Metabolic Syndrome, a condition linked to heart disease and diabetes in women, according to a Kaiser Permanente study that was published today online ahead of print and will appear in the February issue of Diabetes, a journal of the American Diabetes Association.

4 Dec 2009

Breastfeeding reduces a woman's risk of developing Metabolic Syndrome

3 Dec 2009

Exercise remains one of the most effective interventions for peripheral artery disease

Peripheral artery disease (PAD) affects 5 million individuals in the U.S. and is the leading cause of limb amputations. Doctors have long considered exercise to be the single best therapy for PAD, and now a new study helps explain why. Led by researchers at Beth Israel Deaconess Medical Center and published in this week's Online Early Edition of the Proceedings of the National Academy of Sciences (PNAS), the findings demonstrate that a protein called PGC-1alpha plays a key role in the process.

3 Dec 2009

Research finds change in the outlook of people with type 2 diabetes and heart disease

The outlook for individuals with type 2 diabetes and coronary artery disease is not as grim as originally believed, according to new Saint Louis University research published in Circulation, the Journal of the American Heart Association.

2 Dec 2009

Overall use of blood-thinning agents not improving despite more options

Since 1999, stroke survivors have been advised to use aspirin, prescription antiplatelet agents, or prescription anticoagulants to help avoid another stroke. Many large surveys of the U.S. population have reported the use of aspirin for secondary prevention, but commonly combine people with stroke and coronary artery disease, and only rarely report the use of antithrombotic agents other than aspirin.

2 Dec 2009

European Commission and the EMEA approve Angiox in primary PCI for STEMI

The Medicines Company announced today that it has received European approval for the use of Angiox® (bivalirudin) as an anticoagulant in patients with heart attacks (so-called ST-segment elevation myocardial infarction (STEMI)) undergoing emergency heart procedures called primary percutaneous coronary intervention (PCI).

1 Dec 2009

Clinical trail shows PAD patients also experience asymptomatic heart disease

Results of a randomized, controlled clinical trial presented today at the annual meeting of the Radiological Society of North America (RSNA) reveal that one in five patients with narrowing or blockage in arteries that supply blood to the legs and other parts of the body also have significant but silent coronary artery disease.

1 Dec 2009

Phi Health launches high-performance MRI system at RSNA 2009

Phi Health, a healthcare technology company, announced at the RSNA 2009 Annual Meeting in Chicago, IL, November 29, 2009 – December 4, 2009, that it is introducing Memex, a proprietary high-performance, yet low-cost 1.5T MRI system.

1 Dec 2009

MICARDIS receives Health Canada approval to reduce the risk of non-fatal stroke

MICARDIS(R) (telmisartan) has received Health Canada approval to reduce the risk of non-fatal stroke or non-fatal myocardial infarction in patients 55 years or older at high risk of developing major cardiovascular events who cannot tolerate an angiotensin converting enzyme (ACE) inhibitor.

26 Nov 2009

Vitamin D deficiency may increase risk of stroke, heart disease and death, finds study

While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.

24 Nov 2009

New MEMS sensor may help clinicians distinguish stable and unstable plaque during cardiac emergencies

University of Sourthern California biomedical engineer and cardiologist Tzung "John" Hsiai hopes to develop a new tool to help clinicians distinguish cardiac emergencies requiring immediate surgery from chronic problems manageable with drugs and lifestyle change.

24 Nov 2009

Vitamin D: A multi-purpose nutrient for overall health

A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."

24 Nov 2009

Review of study presented at American Heart Association Scientific Sessions

Adding the cholesterol drug niacin to a statin improved HDL ("good") cholesterol levels and significantly reduced carotid arterial plaque buildup measured with ultrasound within 8 months, with further improvement seen at the end of the study (14 months).

21 Nov 2009

Dual niacin-statin therapy improves blood cholesterol levels but does not diminish plaque buildup

The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.

19 Nov 2009

Key findings from AstraZeneca's phase II studies of ticagrelor

AstraZeneca today announced the results of the phase II studies, ONSET/OFFSET and RESPOND for ticagrelor (BRILINTA(TM)) at the annual American Heart Association (AHA) Scientific Sessions in Orlando, FL,with ONSET/OFFSET study results being simultaneously published in the medical journal Circulation.

18 Nov 2009

Clinical Data commences patient enrollment in Stedivaze Phase III trial

Clinical Data, Inc. today announced that it has enrolled the first patient in its initial Phase III trial of Stedivaze™, a potential best-in-class vasodilator for use in cardiac stress testing. The study will evaluate the safety and efficacy of Stedivaze (apadenoson) for use as a pharmacologic stress agent in myocardial perfusion imaging (MPI), a method for detecting defects in the blood supply to the heart.

18 Nov 2009

Coronary Artery Disease News and Research

Latest Coronary Artery Disease News and Research

Second pivotal Phase 3 trial to evaluate investigational Lp-PLA2 inhibitor darapladib initiated

TRYTON-LM clinical study enrolls first two patients

Type 2 diabetics with CAD experience greater antiplatelet activity with prasugrel compared to clopidogrel

Findings suggest severity of atherosclerosis depends on the rate of white blood cell migration

Breastfeeding a child may lower a woman's risk of developing Metabolic Syndrome

Breastfeeding reduces a woman's risk of developing Metabolic Syndrome

Exercise remains one of the most effective interventions for peripheral artery disease

Research finds change in the outlook of people with type 2 diabetes and heart disease

Overall use of blood-thinning agents not improving despite more options

European Commission and the EMEA approve Angiox in primary PCI for STEMI

Clinical trail shows PAD patients also experience asymptomatic heart disease

Phi Health launches high-performance MRI system at RSNA 2009

MICARDIS receives Health Canada approval to reduce the risk of non-fatal stroke

Vitamin D deficiency may increase risk of stroke, heart disease and death, finds study

New MEMS sensor may help clinicians distinguish stable and unstable plaque during cardiac emergencies

Vitamin D: A multi-purpose nutrient for overall health

Review of study presented at American Heart Association Scientific Sessions

Dual niacin-statin therapy improves blood cholesterol levels but does not diminish plaque buildup

Key findings from AstraZeneca's phase II studies of ticagrelor

Clinical Data commences patient enrollment in Stedivaze Phase III trial

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

Coronary Artery Disease News and Research

Latest Coronary Artery Disease News and Research

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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