Gastrointestinal Health News and Research

Latest Gastrointestinal Health News and Research

Modulation of estrobolome may help lower breast cancer risk

Investigating disparities in the composition of the estrobolome, the gut bacterial genes capable of metabolizing estrogens in both healthy individuals and in women diagnosed with estrogen-driven breast cancer may lead to the development of microbiome-based biomarkers that could help mitigate the risk of certain cancers, according to a review paper published April 22 in the JNCI: Journal of the National Cancer Institute.

25 Apr 2016

Under-expressed miR-9 gene may contribute to schizophrenia risk

By turning skin cells into brain neurons, researchers at the Icahn School of Medicine at Mount Sinai have identified that certain tiny molecules aiding in gene expression, known as microRNAs (miRNAs), are under-expressed in the brains of the 14 schizophrenia patients they studied. Their findings, published online today in the journal Cell Reports, show that one of these molecules, a miRNA known as miR-9, is a risk factor that controls the activity of hundreds of genes.

22 Apr 2016

Naturally-occurring molecule can cause immune cells to go into hyperactive state

Researchers at Boston Children's Hospital report that a fatty chemical naturally found in damaged tissues can induce an unexpected kind of immune response, causing immune cells to go into a "hyperactive" state that is highly effective at rallying infection-fighting T-cells. The findings, published online by Science on April 21, could enhance vaccines and make them much more effective.

22 Apr 2016

Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Specific combinations of gut bacteria produce substances that affect myelin content and cause social avoidance behaviors in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal eLife. This research suggests that targeting intestinal bacteria, or their metabolites, could be one way to treat debilitating psychiatric disorders and demyelinating diseases, like multiple sclerosis.

21 Apr 2016

Non-invasive test to diagnose EoE could replace need for repeated endoscopy

A non-invasive test to diagnose and monitor an inflammatory disease that injures the esophagus - called eosinophilic esophagitis or EoE - would replace the need for repeated endoscopy for a growing number of children and adults with this relatively new condition.

21 Apr 2016

Specific oral microbiome linked to pancreatic cancer risk

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research.

20 Apr 2016

New therapy strategy for liver disease shows initial measureable success with norUrso

The new therapy strategy for primary sclerosing cholangitis, a liver disease that at present still cannot be cured with medication, shows initial measureable success with the nor-ursodeoxycholic acid (norUrso).

19 Apr 2016

New study to explore outcomes of pregnancy in Brazilian women with Zika virus

An observational study of pregnant women in Brazil to further understand Zika virus and its impact on reproductive health and fetus development have been launched. William Britt, M.D., professor of pediatric infectious diseases at the University of Alabama at Birmingham, leads the study, which complements his current research in Brazil on cytomegalovirus infection during pregnancy.

18 Apr 2016

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

The removal of the enzyme Dnmt1 during oligodendrocyte progenitor cell (OPC) differentiation in the central nervous system resulted in inefficient myelin formation and neurological deterioration, including loss of control of bodily movements, in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal Cell Reports. The results could lead to a new understanding of multiple sclerosis and other myelin disorders in humans.

16 Apr 2016

VIEKIRAX and EXVIERA achieve high SVR rates in GT1 and GT4 hepatitis C virus infected patients

AbbVie, a global biopharmaceutical company, today announced new real-world data showing 96 percent of genotype 1 (GT1) patients (n=486/505 assessable for analysis) and 100 percent (n=53/53) of genotype 4 (GT4) patients achieved sustained virologic response at 12 weeks post-treatment (SVR12).

15 Apr 2016

Dynamic HBsAg measurements predict HBV inactivity

In patients with hepatitis B e antigen-negative chronic hepatitis B virus infection, repeated measurement of hepatitis B surface antigen during long-term follow-up can help identify those with inactive virus, suggests a chart review.

13 Apr 2016

RedHill Biopharma initiates phase II study of BEKINDA for irritable bowel syndrome

RedHill Biopharma Ltd. (NASDAQ; RDHL) (TASE: RDHL) (“RedHill” or the “Company”), a biopharmaceutical company primarily focused on development and commercialization of late clinical-stage, proprietary, orally-administered, small molecule drugs for inflammatory and gastrointestinal diseases, including cancer, today announced that it has initiated a randomized, double-blind, 2-arm parallel group Phase II clinical study in the U.S. evaluating the safety and efficacy of BEKINDA™ 12 mg in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).

13 Apr 2016

Novel antibiotics to overcome antibacterial resistance

Small and innovative pharmaceutical companies, with products in early stages of development, presented some of their novel approaches and antimicrobial therapies under development during a dedicated session at the annual congress (ECCMID) of the European Society of Clinical Microbiology and Infectious Diseases(ESCMID) in Amsterdam.

13 Apr 2016

Bacteroidia pilins prevalent in human gut and mouth form new type of pili to cling to hosts

Many bacteria interact with their environment through hair-like structures known as pili, which attach to and help mediate infection of host organisms, among other things. Now a U.S.-Japanese research team, including scientists from the Department of Energy's SLAC National Accelerator Laboratory, has discovered that certain bacteria prevalent in the human gut and mouth assemble their pili in a previously unknown way - information that could potentially open up new ways of fighting infection.

12 Apr 2016

Lung ultrasound may be highly effective, safe for diagnosing pneumonia in children

Lung ultrasound has been shown to be highly effective and safe for diagnosing pneumonia in children and a potential substitute for chest X-ray, according to a study conducted at the Icahn School of Medicine at Mount Sinai. Results are currently published in the medical journal Chest.

12 Apr 2016

Substances from tequila plant may help treat osteoporosis

Mexican scientist identified substances from the plant that enhance absorption of calcium in the body.

11 Apr 2016

Keynotes announced for ECCMID 2016

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) previews some of the keynote lectures at the 26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). The globe’s most prominent infection specialists will be gathering at its annual congress in Amsterdam from 9 – 12 April 2016.

8 Apr 2016

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Nonalcoholic fatty liver disease, or NAFLD, comprises a group of liver disorders whose prevalence is widespread and rising. It's estimated that at least one-third of Americans have NAFLD; among obese persons, the figure is 50 percent.

6 Apr 2016

Two common approaches to post-operative AF equally safe, effective

Cleveland Clinic researchers, as part of the Cardiothoracic Surgical Trials Network, have found that two common approaches to post-operative atrial fibrillation - rhythm control and rate control - are equally safe and effective.

5 Apr 2016

Mount Sinai Health System recognized as 'Leaders in LGBT Healthcare Equality' by HRC Foundation

Six campuses of the Mount Sinai Health System - The Mount Sinai Hospital, Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West (formerly known as Mount Sinai Roosevelt), Mount Sinai Queens, and New York Eye and Ear Infirmary of Mount Sinai - have been recognized as "Leaders in LGBT Healthcare Equality" by the Human Rights Campaign (HRC) Foundation, the educational arm of the country's largest lesbian, gay, bisexual and transgender (LGBT) civil rights organization.

5 Apr 2016

Gastrointestinal Health News and Research

Latest Gastrointestinal Health News and Research

Modulation of estrobolome may help lower breast cancer risk

Under-expressed miR-9 gene may contribute to schizophrenia risk

Naturally-occurring molecule can cause immune cells to go into hyperactive state

Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Non-invasive test to diagnose EoE could replace need for repeated endoscopy

Specific oral microbiome linked to pancreatic cancer risk

New therapy strategy for liver disease shows initial measureable success with norUrso

New study to explore outcomes of pregnancy in Brazilian women with Zika virus

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

VIEKIRAX and EXVIERA achieve high SVR rates in GT1 and GT4 hepatitis C virus infected patients

Dynamic HBsAg measurements predict HBV inactivity

RedHill Biopharma initiates phase II study of BEKINDA for irritable bowel syndrome

Novel antibiotics to overcome antibacterial resistance

Bacteroidia pilins prevalent in human gut and mouth form new type of pili to cling to hosts

Lung ultrasound may be highly effective, safe for diagnosing pneumonia in children

Substances from tequila plant may help treat osteoporosis

Keynotes announced for ECCMID 2016

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Two common approaches to post-operative AF equally safe, effective

Mount Sinai Health System recognized as 'Leaders in LGBT Healthcare Equality' by HRC Foundation

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Gastrointestinal Health News and Research

Latest Gastrointestinal Health News and Research

Microbiology eBook

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Automating research - solutions and best practices

How can microdialysis benefit drug development

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