Gene News and Research

Latest Gene News and Research

Deletion on chromosome 11q may guide decision to use chemotherapy for neuroblastoma

When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer.

16 May 2005

Drugs that block the enzyme Odc prevent the onset of cancers

The drug DFMO prevents cancer in laboratory models of lymphoma but fails to kill existing cancerous cells that have lost the ability to self-destruct, according to investigators at St. Jude Children's Research Hospital.

16 May 2005

Scientists discover how excess body fat can lead to the onset of diabetes

One out of 12 people in the western world suffers from type 2 (adult onset) diabetes. Worldwide, 150 million people are diabetic and their numbers are expected to double in the next 20 years, a result of the growing obesity epidemic. Yet, the reasons for the strong correlation between excess body fat and diabetes have been puzzling researchers.

16 May 2005

Combined MRI and mammography more effective at detecting breast cancer in high risk women

Annual screening, using magnetic resonance imaging (MRI) and X-ray mammography, is the best way to detect breast cancer in women that have a high genetic risk of the disease, according to a study published online by The Lancet.

16 May 2005

Disabling gene defuses rheumatoid arthritis in mice

Scientists studying mice have identified a gene that allows immune cells known as neutrophils to protect themselves from the inflammatory chemicals they secrete.

16 May 2005

Cancer can be found earlier in high-risk men if more aggressive screening criteria used

Men at high risk of developing prostate cancer should undergo aggressive screening for the disease. That is the recommendation following a Fox Chase Cancer Center study of 520 men at high-risk of developing prostate cancer in which 25 percent were diagnosed with the disease despite having a low PSA. The findings were presented today at the American Society of Clinical Oncology 41st Annual Meeting.

15 May 2005

Unsuspected protein CD147, regulates the production of plaque-forming peptides that are the defining feature of Alzheimer's

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory have discovered an unsuspected subunit of the protein complex gamma-secretase, which plays a central role in Alzheimer's disease.

15 May 2005

Research findings help predict risk of blood clots in women receiving tamoxifen therapy for breast cancer

New research findings may help physicians determine which women have an increased risk of blood clots when taking tamoxifen for the management of breast cancer, a team led by Dana-Farber Cancer Institute investigators will report at the American Society of Clinical Oncology's annual meeting.

15 May 2005

Humans more prone to cancer than chimpanzees

Chimpanzees and humans share a common ancestor, and even today 99 percent of the two species' DNA is identical. But since the paths of man and chimp diverged 5 million years ago, that one percent of genetic difference appears to have changed humans in an unexpected way: It could have made people more prone to cancer.

15 May 2005

Prostate cancer drug, Omnitarg by Genentech falls short

Research into an experimental prostate cancer drug being developed by Genentech Inc. will probably be abandoned after scientists found that the drug failed to prove effective in a mid-stage trial.

15 May 2005

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

In this week's journal Nature, scientists at the Salk Institute for Biological Studies report that they have solved one of the "holy grail" puzzles of developmental biology: the existence of a mechanism that insures that the exterior of our bodies is symmetrical while inner organs are arranged asymmetrically.

11 May 2005

Virus that targets and kills glioblastoma

Yale School of Medicine scientists have identified a virus that targets and kills glioblastoma, a deadly type of human brain tumor resistant to current medical or surgical treatment, according to a study published as the cover article in the Journal of Virology.

11 May 2005

Targeted Genetics announces new patent for Hyperlipidemia

Targeted Genetics Corporation announced today issuance of U.S. patent #6,887,463, entitled, "Methods and Compositions for Gene Therapy for the Treatment of Defects in Lipoprotein Metabolism."

11 May 2005

Healthy dose of fat is needed for a healthy metabolism

Just when we had all been convinced by information from just about every quarter, that fat was the bad guy of the diet kingdom, new research has found that a healthy dose of fat is needed for a healthy metabolism.

11 May 2005

Drug lowers inflammatory markers associated with risk for heart attack

A preliminary study suggests that use of a drug that inhibits a specific protein in patients with certain genetic variants that increase their risk for heart attack reduced their levels of inflammatory markers associated with heart attack risk, according to a study in the May 11 issue of JAMA.

10 May 2005

Discovery of a fundamental new route into cells may lead to new methods of drug delivery

Researchers from The University of Queensland’s Institute for Molecular Bioscience (IMB), and the Centre for Microscopy and Microanalysis used electron microscopy to uncover new structures, 100,000th of a mm in size, which are involved in the very first step of particle and nutrient uptake into cells.

10 May 2005

Laboratory model of immune system overcomes ethical constraints on studies of hematopoietic stem cells in humans

Scientists at St. Jude Children’s Research Hospital have joined with colleagues at several other institutions to develop a laboratory model of the human immune system. This model will allow scientists to study ways for improving the results of hematopoietic stem cell (HSC) transplantation without putting patients at risk.

10 May 2005

First DNA-based blood test to help detect cystic fibrosis

The Food and Drug Administration (FDA) has approved the first DNA-based blood test to help detect cystic fibrosis. The Tag-It Cystic Fibrosis Kit directly analyzes human DNA to find genetic variations indicative of the disease. The test will be used to help diagnose cystic fibrosis in children and to identify adults who are "carriers" of the gene variations.

10 May 2005

Scientists inhibit tumor formation

By studying mice with skin cancer, researchers at the Huntsman Cancer Institute at the University of Utah discovered a way to inhibit a mutant gene found in up to 30 percent of human tumors.

9 May 2005

Bionomics files key U.S. patents relating to cancer drug target BNO69

Bionomics Limited announced today that it has filed further patent applications in key markets (including the US) relating to its proprietary cancer drug target BNO69.

9 May 2005

Gene News and Research

Latest Gene News and Research

Deletion on chromosome 11q may guide decision to use chemotherapy for neuroblastoma

Drugs that block the enzyme Odc prevent the onset of cancers

Scientists discover how excess body fat can lead to the onset of diabetes

Combined MRI and mammography more effective at detecting breast cancer in high risk women

Disabling gene defuses rheumatoid arthritis in mice

Cancer can be found earlier in high-risk men if more aggressive screening criteria used

Unsuspected protein CD147, regulates the production of plaque-forming peptides that are the defining feature of Alzheimer's

Research findings help predict risk of blood clots in women receiving tamoxifen therapy for breast cancer

Humans more prone to cancer than chimpanzees

Prostate cancer drug, Omnitarg by Genentech falls short

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

Virus that targets and kills glioblastoma

Targeted Genetics announces new patent for Hyperlipidemia

Healthy dose of fat is needed for a healthy metabolism

Drug lowers inflammatory markers associated with risk for heart attack

Discovery of a fundamental new route into cells may lead to new methods of drug delivery

Laboratory model of immune system overcomes ethical constraints on studies of hematopoietic stem cells in humans

First DNA-based blood test to help detect cystic fibrosis

Scientists inhibit tumor formation

Bionomics files key U.S. patents relating to cancer drug target BNO69

eBook: Using iPSCs models for human disease research and drug discovery eBook

Precision in every drop: Inside Hamilton’s syringe technology

Exploring the Future of Neuroscience Drug Discovery

Genomic conservation in Thailand's mangroves