Huntington's Disease News and Research

Latest Huntington's Disease News and Research

Study shows cellular, molecular overlaps in ALS and FTLD

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, manifest in very different ways. In addition, they are known to primarily affect very different regions of the brain.

22 Mar 2024

Study provides insights into the action and specificity of splice-modifying drugs

Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing.

6 Mar 2024

UCLA Health study uncovers astrocytes' role in neuropsychiatric disorders

UCLA Health researchers have discovered a group of specialized support cells in the brain that can regulate behaviors associated with human neuropsychiatric disorders.

29 Feb 2024

Wastewater clues could revolutionize Alzheimer's detection

Review explores the potential of wastewater-based epidemiology (WBE) for diagnosing Alzheimer's disease (AD) through biomarkers in biofluids, offering a non-invasive, cost-effective approach to early detection and large-scale monitoring.

18 Feb 2024

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and the mechanisms by which they cause cell dysfunction and diseases.

30 Jan 2024

Novel learning-based framework for predicting Alzheimer’s disease progression

About 55 million people worldwide are living with dementia, according to the World Health Organization. The most common form is Alzheimer's disease, an incurable condition that causes brain function to deteriorate.

27 Jan 2024

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

Researchers explored how Death Induced by Survival gene Elimination through the analysis of RNA-induced silencing complex-bound short RNAs in Alzheimer's disease models influences neuronal survival and correlates with neurotoxicity in AD.

22 Jan 2024

SickKids scientists untangle cellular waste buildup in Zellweger Spectrum Disorder

For the first time, a research team at The Hospital for Sick Children (SickKids) has uncovered a way to potentially reduce the amount of toxic cellular waste accumulating in patients with Zellweger Spectrum Disorder (ZSD).

9 Jan 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins - and ultimately affect aging.

4 Jan 2024

Sex-specific brain immunometabolism differences may underlie increased Alzheimer's risk in women

Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer's and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women's increased risk for the disease and its severity.

21 Nov 2023

C-Path releases new publication on transforming drug development for neurological disorders

Critical Path Institute (C-Path) is pleased to announce the release of a new peer-reviewed publication, titled "Transforming Drug Development for Neurological Disorders: Proceedings from a Multi-disease Area Workshop," now published in Neurotherapeutics, The Journal of the American Society for Experimental Neurotherapeutics.

9 Nov 2023

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Huntington's disease causes involuntary movements and dementia, has no cure, and is fatal. For the first time, UC Riverside scientists have shown they can slow its progression in flies and worms, opening the door to human treatments.

8 Nov 2023

Immune system proteins play role in early stages of Huntington's disease

Huntington's Disease is the most common neurodegenerative disorder controlled by a single gene and is characterized by motor and cognitive deficits and psychiatric symptoms.

12 Oct 2023

Graphene oxide nanoflakes may help treat Alzheimer's disease

A probable early driver of Alzheimer's disease is the accumulation of molecules called amyloid peptides. These cause cell death, and are commonly found in the brains of Alzheimer's patients.

4 Oct 2023

The role of orexin in the modulation of sleep and wakefulness

The current evidence of the intricate relationship between orexin, rapid eye movement (REM) sleep, and appetite.

24 Aug 2023

Sleep dysfunction is underreported and underrecognized in Huntington's disease

A good night's sleep is essential for everyone. In individuals with Huntington’s disease (HD), sleep disturbances constitute an additional burden that may exacerbate disease outcomes and impact patients’ quality of life.

21 Aug 2023

Zebrafish model could help unlock Parkinson's disease mechanisms

Nearly one million people in the United States are living with Parkinson's disease, making it the second-most common neurodegenerative disease after Alzheimer's.

21 Aug 2023

Scientists discover potential cause of genetic mutations linked to Huntington's disease

Scientists have discovered an additional potential cause of the genetic mutations that result in rare conditions such as Huntington's disease (HD).

18 Aug 2023

Tiny amounts of hydrogen sulfide could help people live healthier for longer

Future therapies to help people live healthy lives for longer could be developed from drugs that release tiny amounts of the gas hydrogen sulfide (H2S), new research has indicated.

31 Jul 2023

Could brain age be used to measure disease stratification in Huntington's disease?

Study evaluated the biological age of the brain as a disease stratification measure for Huntington's disease (HD).

24 Jul 2023

Huntington's Disease News and Research

Latest Huntington's Disease News and Research

Study shows cellular, molecular overlaps in ALS and FTLD

Study provides insights into the action and specificity of splice-modifying drugs

UCLA Health study uncovers astrocytes' role in neuropsychiatric disorders

Wastewater clues could revolutionize Alzheimer's detection

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Novel learning-based framework for predicting Alzheimer’s disease progression

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

SickKids scientists untangle cellular waste buildup in Zellweger Spectrum Disorder

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Sex-specific brain immunometabolism differences may underlie increased Alzheimer's risk in women

C-Path releases new publication on transforming drug development for neurological disorders

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Immune system proteins play role in early stages of Huntington's disease

Graphene oxide nanoflakes may help treat Alzheimer's disease

The role of orexin in the modulation of sleep and wakefulness

Sleep dysfunction is underreported and underrecognized in Huntington's disease

Zebrafish model could help unlock Parkinson's disease mechanisms

Scientists discover potential cause of genetic mutations linked to Huntington's disease

Tiny amounts of hydrogen sulfide could help people live healthier for longer

Could brain age be used to measure disease stratification in Huntington's disease?

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

Huntington's Disease News and Research

Latest Huntington's Disease News and Research

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

The evolution of OCT for retinal imaging and disease intervention

Supercharging Next-Gen Antibody Discovery with AI and High-Throughput Experimentation

Prof. Dr. Kristina Kusche-Vihrog

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