Immunotherapy

Immunotherapy is the concept of using the immune system to treat disease, for example, developing a vaccine against cancer. Immunotherapy may also refer to the therapy of diseases caused by the immune system, allergies for example.

What is Immunotherapy?

Immunotherapy is a treatment that is designed to harness the ability of the body’s immune system to combat infection or disease.

Activation Immunotherapies

Immunotherapy and Helminthic Therapy

Suppression Immunotherapies

Immunotherapy: Past, Present and Future

Adoptive T Cell Therapy Methodology

Adoptive T Cell Therapy Applications

Immunotherapy: The Future of Lung Cancer Treatment?

Neoantigens' Role in Immunotherapy

Latest Immunotherapy News and Research

Molecular drivers and emerging treatments in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

20 Apr 2025

Common pinworm treatment may halt and reverse cancer growth in Merkel cell carcinoma

A common pinworm medication may stop and reverse cancer growth in Merkel cell carcinoma, an aggressive form of skin cancer, according to research led by University of Arizona Cancer Center researchers and published in the Journal of Clinical Investigation.

18 Apr 2025

Some lung cancer patients maintain long-term control after stopping immunotherapy

A subset of patients with non-small cell lung cancer (NSCLC) who discontinued immune checkpoint inhibitor (ICI) therapy due to immune-related adverse events (irAEs) continued to experience long-term disease control.

18 Apr 2025

Study identifies a new key factor contributing to aggressive nature of pancreatic cancer

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates-only 10% after five years.

15 Apr 2025

UVA scientist secures funding to use sound waves for breast cancer therapy

University of Virginia researcher Natasha D. Sheybani, PhD, has received $5.5 million from the federal Department of Defense to support her cutting-edge efforts to use focused sound waves to improve our immune system's ability to battle breast cancer.

15 Apr 2025

Inherited genetic variants play crucial role in cancer development and behavior

A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the National Cancer Institute-funded Clinical Proteomic Tumor Analysis Consortium (CPTAC) and colleagues around the world, has discovered that the genes we are born with-known as germline genetic variants-play a powerful, underappreciated role in how cancer develops and behaves.

15 Apr 2025

Selective depletion of PD-1 positive lymphocytes using a novel bispecific killer engager

This new article publication from Acta Pharmaceutica Sinica B, discusses a bispecific killer engager for targeted depletion of PD-1 positive lymphocytes.

14 Apr 2025

UVA researcher wins major grant to revolutionize breast cancer treatment

A promising approach to achieve safer, more effective, and more precise breast cancer treatment has earned a University of Virginia researcher a new $5.5 million grant.

11 Apr 2025

Boosting tumor-infiltrating lymphocyte therapy with the power of B cells

Researchers at Moffitt Cancer Center have found that tapping into the body's own immune system and activating a type of immune cell known as B cells, could be the key to boosting the effectiveness of tumor-infiltrating lymphocyte, or TIL therapy.

11 Apr 2025

Monitoring Type 2 Diabetes progression using ultrasound localization microscopy

A research paper by scientists at The Second Affiliated Hospital of Zhejiang University School of Medicine presented the application of Ultrasound Localization Microscopy (ULM) for monitoring the progression of Type 2 Diabetes and assessing the efficacy of anti-cytokine immunotherapy.

10 Apr 2025

Sylvester Cancer Center launches clinical trial for patients with high-grade neuroendocrine tumors

A clinical trial for patients with high-grade neuroendocrine tumors is now open for enrollment at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

9 Apr 2025

Tim-3 identified as promising therapeutic target for Alzheimer's disease

Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's disease (AD), but its role in the brain was unknown until now.

9 Apr 2025

IL-12 cytokine factory demonstrates success in targeting hard-to-treat cancers

A team of researchers from the Rice Biotech Launch Pad at Rice University has developed an implantable "cytokine factory" that safely triggers potent immune responses against hard-to-treat cancers, including metastatic melanoma, pancreatic and colorectal tumors.

8 Apr 2025

Blocking an enzyme to overcome immunotherapy resistance in melanoma patients

About 65% of melanoma patients do not respond to immunotherapy. New work by the team of Prof. Max Mazzone (VIB-KU Leuven Center for Cancer Biology) discovered that an enzyme called HPGDS (expressed in a specific subset of macrophages), plays a key role in immunotherapy resistance.

7 Apr 2025

EchoBack CAR T-cells could be a game changer in cancer immunotherapy

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring.

2 Apr 2025

Blood cancer patients should continue BTKi therapy during COVID-19 vaccination

Blood cancer patients who receive a type of anti-cancer therapy should continue to take the drug while having COVID-19 vaccinations, a new study suggests.

2 Apr 2025

ICRAFT platform identifies new targets for cancer immunotherapy

Professor Zeng Zexian's team from the Center for Quantitative Biology at the Peking University Academy for Advanced Interdisciplinary Studies, in collaboration with the Peking University-Tsinghua University Joint Center for Life Sciences, has developed ICRAFT, an innovative computational platform for identifying cancer immunotherapy targets.

1 Apr 2025

New TIL therapy improves treatment's effectiveness in patients with metastatic gastrointestinal cancers

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH).

1 Apr 2025

Lipid accumulation in tumors linked to therapy resistance in breast cancer

A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy.

28 Mar 2025

Understanding the roles of NOTCH signaling in cancer resistance

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have seen minimal improvement, largely due to therapeutic resistance.

27 Mar 2025