Juvenile Diabetes

Diabetes mellitus type 1 (Type 1 diabetes, T1D, T1DM, IDDM, juvenile diabetes) is a form of diabetes mellitus. Type 1 diabetes is an autoimmune disease that results in destruction of insulin-producing beta cells of the pancreas. Lack of insulin causes an increase of fasting blood glucose (around 70-120 mg/dL in nondiabetic people) that begins to appear in the urine above the renal threshold (about 190-200 mg/dl in most people), thus connecting to the symptom by which the disease was identified in antiquity, sweet urine.

What is Type 1 Diabetes?

Type 1 diabetes mellitus describes a condition where the body cannot produce insulin which leads to a very high level of blood sugar and associated complications. The condition, which usually develops in childhood or adolescence, affects millions of people worldwide.

Diabetes Mellitus Type 1 Pathophysiology

Diabetes Mellitus Type 1 Inheritance

Type 1 Diabetes Treatment

Type 1 Diabetes Cure

Type 1 Diabetes Prevention

Type 1 Diabetes Research

Latest Juvenile Diabetes News and Research

Research highlights cardiovascular benefits of semaglutide for overweight adults with impaired kidney function

The anti-obesity medication semaglutide may help to prevent heart attacks, strokes, and other major adverse cardiovascular events (MACE) as well as death in adults with overweight or obesity who don't have diabetes, whether or not they also have impaired kidney function, according to new research to be presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept).

13 Sep 2024

Novel drug-carrying molecule slips past the lung's natural defenses to cure disease

A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng Cai's Soft Biomatter Lab at the University of Virginia School of Engineering and Applied Science.

22 Aug 2024

FDA clears UAB startup's TIX100 for clinical trials

The University of Alabama at Birmingham startup TIXiMED, Inc., has obtained clearance from the United States Food and Drug Administration to proceed to clinical trials under an Investigational New Drug for TIX100, its novel oral Type 1 diabetes drug.

31 Jul 2024

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Researchers have discovered the novel mechanism that underlies a previously reported observation that infection by group A Streptococcus bacteria reduces the risk of later developing Type 1 diabetes.

5 Dec 2023

Existing drug could be repurposed to treat type 1 diabetes, study suggests

Type 1 diabetes is an autoimmune disease that causes the body's immune system to attack and destroy insulin-producing beta cells in the pancreas. Traditional management of type 1 diabetes has primarily involved replacing the missing insulin with injections which, though effective, can be expensive and burdensome.

1 Nov 2023

Repurposing of DFMO could lead to innovative therapies for type 1 diabetes

A recent study led by Indiana University School of Medicine in collaboration with the University of Chicago Medicine presents exciting future possibilities for the management of type 1 diabetes and the potential reduction of insulin dependency.

1 Nov 2023

Hybrid closed-loop technology could be game-changing for pregnant women with type 1 diabetes

For pregnant women with type 1 diabetes, a technology giving insulin doses as informed by a smartphone algorithm, helps them better manage their blood sugars, compared to traditional insulin pumps or multiple daily injections, according to a new randomized trial published in The New England Journal of Medicine and presented at the European Association for the Study of Diabetes (EASD) meeting.

10 Oct 2023

Automated insulin delivery could be a game-changer for pregnant women with type 1 diabetes

Automated insulin delivery should be rolled out to pregnant women with type 1 diabetes - according to researchers at the University of East Anglia.

5 Oct 2023

Antiviral treatment emerges as a potential game-changer in curbing type 1 diabetes progression

New research from the University of Oslo reveals antiviral drugs could help preserve insulin production in children newly diagnosed with type 1 diabetes, potentially slowing down or even preventing the disease. The study, building on earlier findings linking enterovirus to type 1 diabetes, showed that antiviral treatment led to maintained insulin production, proposing a new therapeutic avenue to treat and mitigate the progression of type 1 diabetes.

3 Oct 2023

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models.

25 Aug 2023

Inflammation regulating gene also plays a key role in maintaining normal blood-sugar levels, study shows

A study led by researchers at the Garvan Institute of Medical Research shows for the first time how a gene called RELA, known to regulate inflammation, also plays an essential role in maintaining normal blood-sugar levels.

14 Jun 2023

Bariatric surgery may be an effective treatment for obese people at risk of diabetes, peripheral neuropathy

For more than 100 million Americans who are obese, bariatric surgery may reverse complications related to diabetes, including regenerating damaged nerves, a Michigan Medicine study shows.

10 Apr 2023

Insulin deficiency leads to reduced pancreas size in type 1 diabetes

Individuals with Type 1 diabetes have a smaller pancreas than people without diabetes. This is surprising because insulin-producing beta cells account for just a small fraction of the pancreas, so the loss of beta cells in Type 1 diabetes would not be expected to reduce pancreas size.

10 Mar 2023

Promising alternative strategy for islet transplantation in people with type 1 diabetes

In people with type 1 diabetes, the body's immune system attacks and destroys insulin-producing β cells that control blood glucose levels and are part of a group of cells in the pancreas called pancreatic islets.

1 Mar 2023

Study shows the beneficial effect of verapamil in children with newly-diagnosed type 1 diabetes

Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).

24 Feb 2023

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

For the first time, humans with newly diagnosed Type 1 diabetes, or T1D, have received two treatments called GABA and GAD that have shown promise in animal studies and in isolated human pancreas islets. This investigator-initiated clinical trial, published in Nature Communications, focused exclusively on children with recent onset T1D.

22 Feb 2023

Juvenile Diabetes

Overview

Diabetes Mellitus Type 1 Pathophysiology

Diabetes Mellitus Type 1 Inheritance

Type 1 Diabetes Treatment

Feature Articles

Type 1 Diabetes Cure

Type 1 Diabetes Prevention

Type 1 Diabetes Research

Latest Juvenile Diabetes News and Research

Research highlights cardiovascular benefits of semaglutide for overweight adults with impaired kidney function

Novel drug-carrying molecule slips past the lung's natural defenses to cure disease

FDA clears UAB startup's TIX100 for clinical trials

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Existing drug could be repurposed to treat type 1 diabetes, study suggests

Repurposing of DFMO could lead to innovative therapies for type 1 diabetes

Hybrid closed-loop technology could be game-changing for pregnant women with type 1 diabetes

Automated insulin delivery could be a game-changer for pregnant women with type 1 diabetes

Antiviral treatment emerges as a potential game-changer in curbing type 1 diabetes progression

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

Inflammation regulating gene also plays a key role in maintaining normal blood-sugar levels, study shows

Bariatric surgery may be an effective treatment for obese people at risk of diabetes, peripheral neuropathy

Insulin deficiency leads to reduced pancreas size in type 1 diabetes

Promising alternative strategy for islet transplantation in people with type 1 diabetes

Study shows the beneficial effect of verapamil in children with newly-diagnosed type 1 diabetes

First clinical trial of GABA/GAD focused exclusively on children with recent onset Type 1 diabetes

Armed with hashtags, these activists made insulin prices a presidential talking point

Wafer-thin device could drastically alter the course of treatment for Type 1 diabetes

Global burden of type 1 diabetes likely to double by 2040, study predicts

Tight control of blood sugar in teens may help reduce diabetes-related brain damage

Precision in every drop: Inside Hamilton’s syringe technology

Exploring the Future of Neuroscience Drug Discovery

Genomic conservation in Thailand's mangroves

Juvenile Diabetes

Overview

Feature Articles

Type 1 Diabetes Cure

Type 1 Diabetes Prevention

Type 1 Diabetes Research

Latest Juvenile Diabetes News and Research

Precision in every drop: Inside Hamilton’s syringe technology

Exploring the Future of Neuroscience Drug Discovery

Genomic conservation in Thailand's mangroves

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