Metabolism News and Research

Latest Metabolism News and Research

Scientists identify how cells make choice between various mechanisms to repair DNA

When DNA in the cell nucleus gets damaged, our cells can resort to a variety of repair mechanisms. A recent study published in 'Nature Cell Biology', to which scientists from Helmholtz Zentrum Muenchen made major contributions, elucidates the molecular basis by which a cell makes the choice between these repair mechanisms.

28 Feb 2019

Existing drug for rare kidney disease could benefit patients with mitochondrial disorders

New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders--complex conditions with severe energy deficiency for which no proven effective treatments exist.

27 Feb 2019

New study explores stem cells to gain insight into rotator cuff disease

Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult.

27 Feb 2019

Fusion of mitochondria enables cells to more efficiently use oxygen for energy

Mitochondria are the powerhouses of the cell. And for mitochondria, much like for double-header engines stacked together in a steam train, working in multiples has its benefits.

27 Feb 2019

Novel Imaging Methods for Biomedicine

Wei Min has been awarded the Pittcon 2019 Achievement Award. In this interview, he outlines the current imaging challenges in biomedicine and how his novel chemical imaging methods can overcome these.

From Pittcon 26 Feb 2019

Biophysicists visualize atomic-level dynamics of largest protein-degrading machine

Protein dynamics are essential for their functions. Protein nanomachines made of multiple protein molecules are highly dynamics during their actions on their functional targets, sometime called substrates.

26 Feb 2019

Lack of diversity in cell lines does not allow minorities to reap the benefits of precision medicine

As the biomedical field races to develop therapies based on an individual's genetic makeup, a City of Hope scientist and his colleagues found that some commercial cell lines used for countless laboratory studies have mislabeled ancestry when it comes to minorities.

25 Feb 2019

Fat cells exhibit circadian rhythms affecting critical metabolic functions, study finds

Fat cells in the human body have their own internal clocks and exhibit circadian rhythms affecting critical metabolic functions, new research in the journal Scientific Reports, finds.

25 Feb 2019

New form of hereditary osteoporosis identified

A research group headed by Professor Outi Mäkitie, Unviersity of Helsinki, identified in families with childhood-onset osteoporosis disease-causing mutations in a gene that had previously not been connected with the skeletal system or osteoporosis.

25 Feb 2019

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

An increase in the incidence and mortality rate of cancer has been noted worldwide, especially for lung cancer.

22 Feb 2019

Mitochondrial proteotoxicity appears to be epicentre of molecular pathogenesis

Researchers at the University of Helsinki uncovered the mechanisms for a novel cellular stress response arising from the toxicity of newly synthesized proteins.

22 Feb 2019

Vitamin D supplementation less effective in the presence of obesity, shows study

A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.

21 Feb 2019

New technology measures hormones that influence reproductive health efficiently

The technology, developed by researchers at Imperial College London and The University of Hong Kong, can be used to measure hormones that affect fertility, sexual development and menstruation more quickly and cheaply than current methods.

21 Feb 2019

Discovery of potent compound in native California shrub may lead to treatment for Alzheimer's

The medicinal powers of aspirin, digitalis, and the anti-malarial artemisinin all come from plants. A Salk Institute discovery of a potent neuroprotective and anti-inflammatory chemical in a native California shrub may lead to a treatment for Alzheimer's disease based on a compound found in nature.

21 Feb 2019

Scientists can monitor brain activity to predict epileptic seizures few minutes in advance

Elizabeth Delacruz can't crawl or toddle around like most youngsters nearing their second birthday.

21 Feb 2019

Why melanoma tumors in the brain may be worse?

Melanoma tumors that have spread to the brain are equipped to thwart immunotherapies and targeted therapies that succeed against tumors growing in other sites.

20 Feb 2019

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

In pharmaceutical companies, rats are used commonly in nonclinical studies to investigate the safety, efficacy, and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics.

20 Feb 2019

Researchers identify multiple genetic variants associated with body fat distribution

A new breakthrough from the Genetic Investigation of Anthropometric Traits consortium, which includes many public health researchers from the University of North Carolina at Chapel Hill, identifies multiple genetic variants associated with how the body regulates and distributes body-fat tissue.

18 Feb 2019

High-protein and low-calorie diet helps older adults lose weight safely, shows study

A high-protein, low-calorie diet helps older adults with obesity lose more weight, maintain more muscle mass, improve bone quality and lose "bad" fat, according to results from a new randomized controlled trial led by Wake Forest University researcher Kristen Beavers.

15 Feb 2019

HDL proteome behaves like a tiny Velcro ball that is rolling on surfaces

Cholesterol carried in high-density lipoprotein particles, or HDL cholesterol, has been dubbed the good cholesterol, because people whose HDL levels are high have a lower risk of developing heart disease. That link was first established in 1977 and has been confirmed over and over in epidemiological studies.

15 Feb 2019

Metabolism News and Research

Latest Metabolism News and Research

Scientists identify how cells make choice between various mechanisms to repair DNA

Existing drug for rare kidney disease could benefit patients with mitochondrial disorders

New study explores stem cells to gain insight into rotator cuff disease

Fusion of mitochondria enables cells to more efficiently use oxygen for energy

Novel Imaging Methods for Biomedicine

Biophysicists visualize atomic-level dynamics of largest protein-degrading machine

Lack of diversity in cell lines does not allow minorities to reap the benefits of precision medicine

Fat cells exhibit circadian rhythms affecting critical metabolic functions, study finds

New form of hereditary osteoporosis identified

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

Mitochondrial proteotoxicity appears to be epicentre of molecular pathogenesis

Vitamin D supplementation less effective in the presence of obesity, shows study

New technology measures hormones that influence reproductive health efficiently

Discovery of potent compound in native California shrub may lead to treatment for Alzheimer's

Scientists can monitor brain activity to predict epileptic seizures few minutes in advance

Why melanoma tumors in the brain may be worse?

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

Researchers identify multiple genetic variants associated with body fat distribution

High-protein and low-calorie diet helps older adults lose weight safely, shows study

HDL proteome behaves like a tiny Velcro ball that is rolling on surfaces

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production