Metabolism News and Research

Latest Metabolism News and Research

Thyroid journal publishes new ATA guidelines for management of anaplastic thyroid cancer

Anaplastic thyroid cancer is a rare form of thyroid tumor, but it is also the most deadly. Newly developed evidence-based recommendations for the diagnosis, treatment, and long-term monitoring and follow-up care of patients with this extremely aggressive form of thyroid cancer are published in Thyroid, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

8 Nov 2012

Washington University, SRI investigators launch Global Metabolomic Initiative

Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of bacteria, yeast, plants, animals and people.

7 Nov 2012

Duration of ibuprofen use may reduce risk of bladder cancer in northern New England patients

Dartmouth researchers have found that duration of ibuprofen use was associated with a reduced risk of bladder cancer in patients in northern New England, which has a high mortality rate of this disease. In a 2012 collaborative project with the National Cancer Institute, Margaret Karagas, PhD, co-director, Cancer Epidemiology & Chemoprevention program at Norris Cotton Cancer Center, and Professor of Community and Family Medicine at the Geisel School of Medicine at Dartmouth, and Richard Waddell, D.Sc, Research Assistant Professor of Medicine at the Geisel School of Medicine, looked for connections between ibuprofen use and bladder cancer.

7 Nov 2012

FDA EMDAC votes unanimously in support of Signifor use for treatment of Cushing's disease

The US Food and Drug Administration's (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) has voted unanimously in support of the use of Signifor (pasireotide) for the treatment of patients with Cushing's disease who require medical therapeutic intervention.

7 Nov 2012

Link between SFRP4 protein and risk of type 2 diabetes

When a patient is diagnosed with type 2 diabetes, the disease has usually already progressed over several years and damage to areas such as blood vessels and eyes has already taken place. To find a test that indicates who is at risk at an early stage would be valuable, as it would enable preventive treatment to be put in place.

7 Nov 2012

Results from liraglutide and exenatide head-to-head comparison trial on type 2 diabetes

A direct, head-to-head comparison of two of the newer treatments available for type 2 diabetes yielded mixed results.

7 Nov 2012

Dysregulation of CISTR-ACT causes brachydactyly type E

The patients have single short fingers (metacarpals) and toes (metatarsals) and can be restricted in growth due to a shortened skeleton. This hereditary disease is called brachydactyly type E (Greek for short fingers).

6 Nov 2012

Soy products do not prevent onset of vasomotor symptoms in women

A team of investigators led by UC Davis found that eating soy products such as soy milk and tofu did not prevent the onset of hot flashes and night sweats as women entered menopause.

2 Nov 2012

High blood cholesterol far more common than previously recognized

High blood cholesterol, a serious hereditary disease, is far more common than previously recognised and not treated sufficiently.

2 Nov 2012

CSHL scientists discover new way to specifically target and kill cancer cells

Cancer cells grow fast. That's an essential characteristic of what makes them cancer cells. They've crashed through all the cell-cycle checkpoints and are continuously growing and dividing, far outstripping our normal cells. To do this they need to speed up their metabolism.

1 Nov 2012

Nitisinone treatment effectively prevents tyrosinemia in children

A consortium of Quebec researchers coordinated by the Medical Genetics Service of the Sainte-Justine UHC has just published the findings of a 25-year study on the treatment of tyrosinemia, a life-threatening liver disease of genetic origin, which is screened at birth in the province of Quebec, where it is much more frequent than anywhere else in the world.

1 Nov 2012

Sprint Bioscience, TPP partner to develop small molecule inhibitors of choline kinase for cancer

TPP Global Development Ltd (TPP) enters into a collaboration with Sprint Bioscience AB to develop small molecule inhibitors of choline kinase as human therapeutics for the treatment of cancer.

30 Oct 2012

Positive interim data from XBiotech monoclonal antibody Phase II study for type 2 diabetes

XBiotech, a privately held biotechnology company, announced positive interim analysis results today from a Phase II study using a True Human monoclonal antibody (MABp1) in patients with type 2 diabetes. Results from this study continue to reinforce the role of IL-1α as a master regulator of chronic inflammation in multiple disease states, and the therapeutic benefits of neutralizing antibodies produced from the XBiotech platform.

29 Oct 2012

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Doxorubicin, a 50-year-old chemotherapy drug still in widespread use against a variety of cancers, has long been known to destroy heart tissue, as well as tumors, in some patients.

29 Oct 2012

Resveratrol does not appear to offer metabolic benefits in healthy women

Resveratrol, an ingredient in red wine thought to improve insulin sensitivity, reduce risk of heart disease and increase longevity, does not appear to offer these benefits in healthy women, new research at Washington University School of Medicine in St. Louis indicates.

26 Oct 2012

Study identifies essential mechanism that regulates calcium flow into mitochondria

Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell's energy storehouse - the mitochondria -- is important for understanding a cell's normal state, as well as what happens when things go wrong, for example in cancer, cardiovascular disease, neurodegeneration, and many rare disorders of the mitochondria.

26 Oct 2012

Sevoflurane, propofol produce different metabolic patterns in brains of unconscious children

Two commonly used anesthetics produce different metabolic patterns in the brains of unconscious children, according to a study from the November issue of a Anesthesiology.

26 Oct 2012

Study indicates that Firemaster 550 is an endocrine disruptor

The flame-retardant mixture known as "Firemaster 550" is an endocrine disruptor that causes extreme weight gain, early onset of puberty and cardiovascular health effects in lab animals, according to a new study spearheaded by researchers from North Carolina State University and Duke University.

25 Oct 2012

New biomarker measures aggressiveness of primary prostate tumors

Research out of Roswell Park Cancer Institute (RPCI) supports the adoption of a new biomarker to measure the aggressiveness of primary prostate tumors.

24 Oct 2012

TSRI scientists to study structural rules that govern nuclear receptors

A consortium of scientists from both campuses of The Scripps Research Institute (TSRI) has been awarded $2.7 million from the National Institute of General Medical Sciences of the National Institutes of Health to study the structural rules that govern a large superfamily of proteins that help regulate critical functions such as reproduction, development and metabolism.

24 Oct 2012

Metabolism News and Research

Latest Metabolism News and Research

Thyroid journal publishes new ATA guidelines for management of anaplastic thyroid cancer

Washington University, SRI investigators launch Global Metabolomic Initiative

Duration of ibuprofen use may reduce risk of bladder cancer in northern New England patients

FDA EMDAC votes unanimously in support of Signifor use for treatment of Cushing's disease

Link between SFRP4 protein and risk of type 2 diabetes

Results from liraglutide and exenatide head-to-head comparison trial on type 2 diabetes

Dysregulation of CISTR-ACT causes brachydactyly type E

Soy products do not prevent onset of vasomotor symptoms in women

High blood cholesterol far more common than previously recognized

CSHL scientists discover new way to specifically target and kill cancer cells

Nitisinone treatment effectively prevents tyrosinemia in children

Sprint Bioscience, TPP partner to develop small molecule inhibitors of choline kinase for cancer

Positive interim data from XBiotech monoclonal antibody Phase II study for type 2 diabetes

Scientists identify mechanism via Top2b enzyme that drives doxorubicin-induced heart damage

Resveratrol does not appear to offer metabolic benefits in healthy women

Study identifies essential mechanism that regulates calcium flow into mitochondria

Sevoflurane, propofol produce different metabolic patterns in brains of unconscious children

Study indicates that Firemaster 550 is an endocrine disruptor

New biomarker measures aggressiveness of primary prostate tumors

TSRI scientists to study structural rules that govern nuclear receptors

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications

Precision in every drop: Inside Hamilton’s syringe technology