Metabolism News and Research

Latest Metabolism News and Research

Merck announces data from MK-3102 Phase IIb trial on type 2 diabetes

Merck, known as MSD outside the United States and Canada, today announced Phase IIb data for MK-3102, the company's investigational once-weekly DPP-4 inhibitor in development for the treatment of type 2 diabetes.

4 Oct 2012

Roche announces availability of new HIV-1 viral load test in the U.S.

Roche announced today the U.S. availability of a new HIV-1 viral load test based on the company's proprietary dual-target approach. The COBAS TaqMan HIV-1 Test v2.0 for use with the High Pure System enables labs to combine an FDA-approved process for manual specimen preparation with an automated real-time PCR analyzer for amplification and detection.

From Roche Sequencing and Life Science 4 Oct 2012

Prevalence of diabetic complications is race-specific

Diabetes is among the ten leading causes of death in both white and African American patients, but the prevalence of diabetic complications are race-specific, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

4 Oct 2012

BMI concerns raised for childhood stem cell transplantation survivors

Childhood survivors of hematologic malignancies treated with allogeneic hematopoietic stem cell transplantation should undergo long-term monitoring of their body mass index and lean body mass, US researchers recommend.

3 Oct 2012

New mouse model could foster ALS, Paget's and dementia breakthroughs

Efforts to treat disorders like Lou Gehrig's disease, Paget's disease, inclusion body myopathy and dementia will receive a considerable boost from a new research model created by UC Irvine scientists.

3 Oct 2012

Low vitamin D levels may increase death in African American and Caucasian older adults

Low levels of vitamin D and high levels of parathyroid hormone are associated with increased mortality in African American and Caucasian older adults, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM).

3 Oct 2012

GW researcher to help HIV patients better understand treatments for cardiovascular issues

In 1980, men and women who were diagnosed with the human immunodeficiency virus (HIV) had little to no hope of living long, full lives. Thanks to advances in science and medicine, this is no longer the case. HIV patients now live a near-normal lifespan. However, as patients live longer, new medical issues arise.

3 Oct 2012

Low serum levels of IGF-1 and IGFBP-3 associated with Alzheimer's in men

Low serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) are associated with Alzheimer's Disease in men, but not women, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

3 Oct 2012

Obesity from high-energy diets may impair brain, fuel overeating

"Betcha can't eat just one!" For obese people trying to lose weight, the Lays potato chip advertising slogan hits a bit too close to home as it describes the daily battle to resist high calorie foods.

3 Oct 2012

Research report helps explain how macrophages accumulate triglycerides

A research report appearing in the Journal of Leukocyte Biology helps explain how specific immune cells, called macrophages, accumulate triglycerides to support their function.

2 Oct 2012

F-18-FLT-PET predicts early response to chemoradiotherapy in head and neck cancer

Determining the optimal treatment course and predicting outcomes may get easier in the future for patients with head and neck sqaumous cell carcinomas (HNSCCs) with the use of an investigational imaging agent.

2 Oct 2012

Exelixis announces interim data from cabozantinib phase 2 trial on metastatic CRPC

Exelixis, Inc. today announced interim data from 51 patients with metastatic castration-resistant prostate cancer (CRPC) and bone metastases receiving a 40 mg daily dose of cabozantinib in an ongoing non-randomized expansion (NRE) cohort of a phase 2 randomized discontinuation trial.

1 Oct 2012

Women with early menopause more likely to develop heart attack or stroke

Women who experience early menopause are more likely to have a heart attack or stroke than women whose menopause occurs at a later age, according to a new study by Melissa Wellons, M.D., assistant professor of Medicine in the Vanderbilt Division of Diabetes, Endocrinology and Metabolism.

29 Sep 2012

Intarcia announces results from ITCA 650 phase 2 study on type 2 diabetes

Intarcia Therapeutics, Inc. announced that an analysis of the results of a phase 2 clinical study of ITCA 650 (continuous subcutaneous delivery of exenatide) for the treatment of type 2 diabetes will be presented at the 48th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Berlin, Germany on Wednesday, October 3, 2012.

29 Sep 2012

Rapamycin can alleviate frontotemporal lobar degeneration

A southern Taiwan-based National Cheng Kung University (NCKU) research team has discovered that rapamycin, a drug as a autophagy activator is a possible treatment to alleviating frontotemporal lobar degeneration (FTLD), one of the mainly causes of dementia, and so far no medication can be used.

29 Sep 2012

Inhibiting TRPV4 protects against diet-induced obesity, inflammation and insulin resistance

Ember Therapeutics, Inc., a company harnessing breakthroughs in brown fat biology and insulin sensitization to revolutionize the treatment of metabolic disease, today announced the publication of key preclinical data demonstrating that inhibition of the Transient Receptor Potential Vanilloid (TRPV) family of ion channels - specifically TRPV4 - resulted in activation of brown/beige fat and protection from diet-induced obesity, inflammation and insulin resistance. Ember holds an exclusive option to license these TRPV4 findings and technology.

28 Sep 2012

Molecular link between thermogenesis and development of inflammation in fat cells

Flipping a newly discovered molecular switch in white fat cells enabled mice to eat a high-calorie diet without becoming obese or developing the inflammation that causes insulin resistance, report scientists from Dana-Farber Cancer Institute.

28 Sep 2012

Two-part ACR guidelines on gout

Gout is one of the most common forms of inflammatory arthritis, affecting nearly 4% of adult Americans. Newly approved guidelines that educate patients in effective methods to prevent gout attacks and provide physicians with recommended therapies for long-term management of this painful disease are published in Arthritis Care & Research, a peer-reviewed journal of the American College of Rheumatology (ACR).

28 Sep 2012

Dietary habits associated with NAFLD in obese children

Research has identified a number of variables associated with nonalcoholic fatty liver disease in obese children.

27 Sep 2012

MicroRNA processing in fat tissue plays a major role in aging and stress resistance

As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor - microRNA processing in fat tissue - which plays a major role in aging and stress resistance.

27 Sep 2012

Metabolism News and Research

Latest Metabolism News and Research

Merck announces data from MK-3102 Phase IIb trial on type 2 diabetes

Roche announces availability of new HIV-1 viral load test in the U.S.

Prevalence of diabetic complications is race-specific

BMI concerns raised for childhood stem cell transplantation survivors

New mouse model could foster ALS, Paget's and dementia breakthroughs

Low vitamin D levels may increase death in African American and Caucasian older adults

GW researcher to help HIV patients better understand treatments for cardiovascular issues

Low serum levels of IGF-1 and IGFBP-3 associated with Alzheimer's in men

Obesity from high-energy diets may impair brain, fuel overeating

Research report helps explain how macrophages accumulate triglycerides

F-18-FLT-PET predicts early response to chemoradiotherapy in head and neck cancer

Exelixis announces interim data from cabozantinib phase 2 trial on metastatic CRPC

Women with early menopause more likely to develop heart attack or stroke

Intarcia announces results from ITCA 650 phase 2 study on type 2 diabetes

Rapamycin can alleviate frontotemporal lobar degeneration

Inhibiting TRPV4 protects against diet-induced obesity, inflammation and insulin resistance

Molecular link between thermogenesis and development of inflammation in fat cells

Two-part ACR guidelines on gout

Dietary habits associated with NAFLD in obese children

MicroRNA processing in fat tissue plays a major role in aging and stress resistance

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