Metabolism News and Research

Latest Metabolism News and Research

NOXXON commences NOX-A12 Phase IIa trial in relapsed MM

NOXXON Pharma today announced the treatment of the first cohort of three multiple myeloma (MM) patients in a Phase IIa clinical trial of its anti-CXCL12/SDF-1 (CXC chemokine ligand 12 / Stromal Cell-Derived Factor-1) Spiegelmer NOX-A12.

26 Sep 2012

Wiley announces publication of 6-volume Encyclopedia of Drug Metabolism and Interactions

Wiley is pleased to announce publication of the state-of-the-art, 6-volume Encyclopedia of Drug Metabolism and Interactions.

25 Sep 2012

New online, peer-reviewed journal on cardiovascular endocrinology

Wolters Kluwer Health is pleased to announce the publication of Cardiovascular Endocrinology, a new online, peer-reviewed journal committed to fostering effective collaboration between cardiologists and endocrinologists in addressing diabetes, hypertension, dyslipidemia, and related diseases and conditions.

24 Sep 2012

Interleukin-6 could affect hunger and satiety

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have identified a molecule in the immune system that could affect hunger and satiety. The researchers hope that new treatments for obesity will benefit from this finding.

24 Sep 2012

New mouse models can help scientists study SECISBP2 syndrome

New mouse models can help scientists study a rare disease, called SECISBP2 syndrome, that causes abnormal thyroid hormone metabolism, delayed bone maturation, as well as other abnormal characteristics that vary by individual, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.

24 Sep 2012

Maternal choline intake could essentially change fetal genetic expression into adulthood

Just as women are advised to get plenty of folic acid around the time of conception and throughout early pregnancy, new research suggests another very similar nutrient may one day deserve a spot on the obstetrician's list of recommendations.

24 Sep 2012

What moms eat before pregnancy affects children epigenetically

Everyone knows that what mom eats when pregnant makes a huge difference in the health of her child. Now, new research in mice suggests that what she ate before pregnancy might be important too. According to a new research report published online in The FASEB Journal, what a group of female mice ate-before pregnancy-chemically altered their DNA and these changes were passed to her offspring. These DNA alterations, called "epigenetic" changes, drastically affected the pups' metabolism of many essential fatty acids.

21 Sep 2012

Children with mild to moderate kidney disease have carotid atherosclerosis

A federally funded study led by researchers at Johns Hopkins Children's Center has found that children with mild to moderate kidney disease have abnormally thick neck arteries, a condition known as carotid atherosclerosis, usually seen in older adults with a long history of elevated cholesterol and untreated hypertension.

21 Sep 2012

MU endocrinologist to receive American Heart Association lifetime achievement award

One of the first researchers to study the deadly link between cardiovascular disease and diabetes will receive an American Heart Association lifetime achievement award today at a ceremony in Washington, D.C. The award presented to University of Missouri endocrinologist James Sowers, MD, recognizes his more than 30 years of accomplishments as a physician, scientist and educator.

21 Sep 2012

ChromaDex announces findings from pTeroPure Phase 2/3 trial on high blood pressure

ChromaDex Corporation announced today findings from a Phase 2/3 trial at the University of Mississippi Medical Center showing its patented nutritional ingredient pTeroPure (pterostilbene) significantly reduced blood pressure in adults.

21 Sep 2012

Iron transport may contribute to diabetes

Scientists have been trying to explain the causes of diabetes for many years. Researchers at the University of Copenhagen and Novo Nordisk A/S have now shown that the increased activity of one particular iron-transport protein destroys insulin-producing beta cells. In addition, the new research shows that mice without this iron transporter are protected against developing diabetes.

21 Sep 2012

Cytochroma commences CTAP101 phase 3 study in secondary hyperparathyroidism

Cytochroma today announced the initiation of a phase 3 study of CTAP101 capsules in patients with secondary hyperparathyroidism (SHPT), stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency.

21 Sep 2012

Scientists discover bone abnormalities in rats undergoing chronic lack of sleep

Scientists at the Medical College of Wisconsin, in a team led by Carol Everson, Ph.D., professor of neurology, cell biology, neurobiology and anatomy, have discovered abnormalities in bone and bone marrow in rats undergoing chronic lack of sleep. They discovered abnormalities in serum markers of bone metabolism in sleep-deprived rats, which led them to conduct direct measurements of bone parameters; this time in rats experiencing recurrent sleep restriction during a large portion of their young adulthood.

19 Sep 2012

Diet, lack of AgRP-neurons can lead to obesity and diabetes

The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers in The EMBO Journal. The outcome, however, depends on the type of diet that the animals are fed.

19 Sep 2012

Mephedrone may cause memory loss

The party drug mephedrone can cause lasting damage to the brain, according to new research led by the University of Sydney.

19 Sep 2012

Additional campus-based health promotion strategies needed for students

A new study published today in the journal Applied Physiology, Nutrition, and Metabolism looks beyond the much-feared weight gain common to first-year students and reports on the full 4-year impact of higher education on weight, BMI, and body composition.

17 Sep 2012

Modifying fat intake during pregnancy benefits children regardless of mother's size

If you are overweight and pregnant, your baby isn't destined to a life of obesity after all, according to a new research report published online in The FASEB Journal. In the report, a team of U.S. scientists show that modifying fat intake during pregnancy to a moderate level is enough to benefit the child regardless of the mother's size.

17 Sep 2012

New test to assess viral load of cytomegalovirus

Roche announced today the commercial availability of a new test to assess a patient's viral load of cytomegalovirus (CMV). Physicians use information from the test to help them manage patients who have been diagnosed with CMV disease, specifically patients with an immune system that has been suppressed for solid organ transplantation.

From Roche Sequencing and Life Science 17 Sep 2012

Researchers identify gene mutations in Wolfram syndrome that affects insulin-secreting beta cells

The rare disorder Wolfram syndrome is caused by mutations in a single gene, but its effects on the body are far reaching. The disease leads to diabetes, hearing and vision loss, nerve cell damage that causes motor difficulties, and early death.

17 Sep 2012

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

vasopharm GmbH, a pharmaceutical company dedicated to the discovery and development of novel therapeutics for the treatment of cerebro- and cardiovascular diseases, today announces that the explorative phase IIa NOSTRA trial in Traumatic Brain Injury Patients met all clinical endpoints for safety and in addition demonstrated strong evidence of clinical benefit in patients.

17 Sep 2012

Metabolism News and Research

Latest Metabolism News and Research

NOXXON commences NOX-A12 Phase IIa trial in relapsed MM

Wiley announces publication of 6-volume Encyclopedia of Drug Metabolism and Interactions

New online, peer-reviewed journal on cardiovascular endocrinology

Interleukin-6 could affect hunger and satiety

New mouse models can help scientists study SECISBP2 syndrome

Maternal choline intake could essentially change fetal genetic expression into adulthood

What moms eat before pregnancy affects children epigenetically

Children with mild to moderate kidney disease have carotid atherosclerosis

MU endocrinologist to receive American Heart Association lifetime achievement award

ChromaDex announces findings from pTeroPure Phase 2/3 trial on high blood pressure

Iron transport may contribute to diabetes

Cytochroma commences CTAP101 phase 3 study in secondary hyperparathyroidism

Scientists discover bone abnormalities in rats undergoing chronic lack of sleep

Diet, lack of AgRP-neurons can lead to obesity and diabetes

Mephedrone may cause memory loss

Additional campus-based health promotion strategies needed for students

Modifying fat intake during pregnancy benefits children regardless of mother's size

New test to assess viral load of cytomegalovirus

Researchers identify gene mutations in Wolfram syndrome that affects insulin-secreting beta cells

vasopharm's explorative phase IIa NOSTRA trial in TBI meets clinical endpoints for safety

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