Metabolism News and Research

Latest Metabolism News and Research

Aerobics increases blood protein that may suppress appetite

Three months of aerobic exercise decreased body fat and calorie intake in overweight and obese people, according to a new study, and the researchers believe that changes to a central nervous system factor are responsible. The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

16 Jun 2008

Largest ever Canadian study on osteoporosis informs health policy

Dr David Goltzman and his team from the Research Institute of the McGill University Health Centre (RI MUHC) and McGill University - along with colleagues from across Canada - have issued new recommendations to public health authorities about how to best cope with osteoporosis, a bone disease which leads to increased risk of fracture, particularly in the elderly.

16 Jun 2008

European researchers take lid off the genome

European researchers have made significant progress unravelling how genes are governed and why this sometimes goes wrong in disease.

15 Jun 2008

Nanoparticles trigger built-in cell-death signal to overcome drug resistance

One of the most vexing problems in treating cancer is the propensity of tumors to develop resistance to a wide range of anticancer drugs. Over 70 percent of ovarian cancer patients, for example, have drug-resistant tumors at the time of their initial diagnosis, and virtually all patients who relapse have drug-resistant tumors.

15 Jun 2008

Drug combo offers new approach for reversing type 1 diabetes

Promising results from a study that tested a new approach for reversing Type 1 diabetes are being presented this week at the American Diabetes Association's 68th Annual Scientific Session in San Francisco.

11 Jun 2008

Having heart surgery? Watch your blood sugar

Nearly half of all heart surgery patients may experience blood sugar levels high enough to require temporary insulin treatment after their operation, even though they've never had diabetes, according to a new study from the University of Michigan Health System.

10 Jun 2008

Decisions best made on a full stomach

British researchers say decisions are best made on a full stomach. The scientists say a full stomach minimises hasty decisions and prevents impulsive actions.

8 Jun 2008

Discovery of new signal pathway important to diabetes research

Scientists at Karolinska Institutet and Miami University have discovered that cells in the pancreas cooperate - signal - in a way hitherto unknown. The discovery can eventually be of significance to the treatment of diabetes.

4 Jun 2008

Synthetic molecules developed by Hebrew University researchers hold promise for new family of anti-cancer drugs

Synthetic molecules designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.

4 Jun 2008

Prostate Cancer Foundation 'beefs up' cancer research

The Prostate Cancer Foundation (PCF) has committed more than $19 million in new research funding for scientific investigations focused on discovering new treatments for recurrent prostate cancer. A total of eight programs representing 18 leading research institutions and 36 researchers were selected as part of the foundation's 2008 Challenge Awards. The funded programs will receive the first of three annual payments, ranging between $500,000 and $1.0 million per program, this week.

4 Jun 2008

How the cholesterol-lowering drug ezetimibe (Zetia) works

A new study in the June issue of Cell Metabolism, a Cell Press publication, sheds light on the action of the drug ezetimibe (trade name Zetia), which is used to treat high cholesterol. Ezetimibe is unique among cholesterol-lowering drugs in that it works by cutting the amount of cholesterol taken in from the diet rather than by blocking cholesterol's manufacture in the body.

3 Jun 2008

You may not be what you eat after all!

A new study shows that increased eating does not necessarily lead to increased fat. The finding in the much-studied roundworm opens the possibility of identifying new targets for drugs to control weight, the researchers say.

3 Jun 2008

Thinness versus obesity not directly linked to eating habits

Whether you are fat or thin isn't directly determined by your eating habits, suggest researchers who report new findings made in worms in the June issue of Cell Metabolism, a publication of Cell Press.

3 Jun 2008

Paclitaxel Poliglumex/Capecitabine regimen well tolerated and active in metastatic breast cancer

At the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO), data were presented from a phase II investigator-sponsored trial paclitaxel poliglumex (Opaxio, CT-2103) in combination with capecitabine in first-line treatment of patients with metastatic breast cancer (MBC).

3 Jun 2008

Personal genomes may lead to personalized vitamin supplements

As the cost of sequencing a single human genome drops rapidly, with one company predicting a price of $100 per person in five years, soon the only reason not to look at your "personal genome" will be fear of what bad news lies in your genes.

2 Jun 2008

Mouse ovaries and testes age in unique ways

Aging leads to large changes in gene activity in the ovaries of mice, but only limited changes in testes, according to research published in the open-access journal, BMC Biology.

2 Jun 2008

Genta announces initial trial results for novel drug for bone disease

Genta Incorporated has announced the release of final results from the Company's Phase 1 clinical trial of G4544, a proprietary small molecule that is intended as a treatment for diseases associated with accelerated bone loss. Results showed that the drug was very well-tolerated, and that blood levels were achieved in a range that is known to be clinically bioactive. The data were featured in a poster session at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago on Saturday, May 31, 2008.

2 Jun 2008

Molecular fingerprint of cocaine addiction revealed

The first large-scale analysis of proteins in the brains of monkeys addicted to cocaine reveals new information on how long-term cocaine use changes the amount and activity of various proteins affecting brain function.

27 May 2008

Researchers find multiple cancer genes cooperate to cause malignant cell transformation

Pinpointing new targets for cancer treatments is as difficult as finding a needle in a haystack, yet a University of Rochester team has discovered an entire novel class of genes they believe will lead to a greater understanding of cancer cell function and the next generation of effective and less harmful therapies for patients.

26 May 2008

Discovery of potential target for elevated triglycerides

Diabetes researchers at the John G. Rangos Sr. Research Center at Children's Hospital of Pittsburgh of UPMC have identified a potential target for the development of new therapies to treat hypertriglyceridemia, a lipid disorder commonly seen in people who are obese and diabetic. Results of their study are published in the June issue of the Journal of Clinical Investigation.

26 May 2008