Metabolism News and Research

Latest Metabolism News and Research

Intracellular antibody mops up mutant protein in Huntington's disease model

Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the brain cells of people with Huntington's.

26 May 2008

Scientists reveal the genetic determinants of fat storage in cells

New research by the Gladstone Institutes of Cardiovascular Disease (GICD) and the University of California, San Francisco (UCSF), has revealed the genetic determinants of fat storage in cells, which may lead to a new understanding of and potential treatments for obesity, diabetes, and heart disease. While scientists have long understood that lipid droplets contribute to fat build up in cells, the genes involved in droplet biology have been a focus of extensive research.

21 May 2008

Spectral Modeling technology substantiated through creation of antipsychotic bank of drug candidates

LIUS Molecular Design is pleased to announce that it has successfully created two antipsychotic drug candidates with third party confirmation of predicted biological activities via in vitro testing.

19 May 2008

Pfizer and Peter MacCallum support the future of cancer research in Australia

Australia's reputation for excellence in cancer research has been strengthened with the launch of the Peter MacCallum Pfizer Translational Oncology Research Collaborative Hub (TORCH) at the Peter MacCallum Cancer Centre, by the Minister for Innovation, Industry, Science and Research, Senator the Hon. Kim Carr.

18 May 2008

New dimension discovered in body clock rhythm

Research on what makes the body clock tick has led Dr Michael Hastings of the MRC Laboratory of Molecular Biology in Cambridge to discover a new and unanticipated cog in the human body clock. A patent for the compound involved has been filed by MRC Technology. The results, published in Science, could lead to therapies for people whose sleep is disrupted by shift work or old age.

18 May 2008

Drug therapy for phenylketonuria reverses heart damage

A pricy drug used to treat a rare but well-known genetic disorder may hold wider promise as a treatment for millions of Americans with potentially lethal enlarged hearts, due mainly to high blood pressure, a study from Johns Hopkins shows.

13 May 2008

Vitamin D protects cells from stress that can lead to cancer

By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.

13 May 2008

Model shows how mutation tips biochemistry to cause Alzheimer's

Your fate can be determined by tiny events. Imagine you live in the city and you walk everywhere to get exercise - you are healthy and not afraid of getting mugged. You almost never eat breakfast so you don't stop at the donut shop on the way to work, until one day the manager replaces the girl at the counter with her pretty red-haired younger sister. This seemingly unimportant change in your world is just enough to overcome your ability to resist high-fat temptation. A million donuts later, your cholesterol level surges and then your heart gives out. Curse you, little red-haired girl!

12 May 2008

Radioactive carbon-14 determines the number of fat cells remains constant in all body types

The radioactive carbon-14 produced by above-ground nuclear testing in the 1950s and '60s has helped researchers determine that the number of fat cells in a human's body, whether lean or obese, is established during the teenage years. Changes in fat mass in adulthood can be attributed mainly to changes in fat cell volume, not an increase in the actual number of fat cells.

9 May 2008

Having a big bum may protect you from diabetes!

Researchers at Harvard Medical School in the U.S. suggest that having a big bum may be a good thing from a health perspective.

7 May 2008

Fat transplantation can have metabolic benefits

When transplanted deep into the abdomen, fat taken from just under the skin comes with metabolic benefits, or at least it does in mice, reveals a new study in the May issue of Cell Metabolism, a Cell Press publication.

6 May 2008

Blocked brain enzyme shows potential as target for appetite control, weight loss and blood sugar management

Imagine being able to tone down appetite and promote weight loss, while improving the body's ability to handle blood sugar levels.

6 May 2008

Gut hormone makes food appear more desirable

A gut hormone that causes people to eat more does so by making food appear more desirable, suggests a new report in the May issue of Cell Metabolism, a publication of Cell Press. In a brain imaging study of individuals, the researchers found that reward centers respond more strongly to pictures of food in subjects who had received an infusion of the hormone known as ghrelin.

6 May 2008

Joslin researchers find certain body fat reduces insulin resistance

It has long been known that type 2 diabetes is linked to obesity, particularly fat inside the belly. Now, researchers at the Joslin Diabetes Center have found that fat from other areas of the body can actually reduce insulin resistance and improve insulin sensitivity.

6 May 2008

Drinking patterns in adolescents may be set after only a few exposures to alcohol

Scientists at Duke University Medical Center have shown a connection between early drinking patterns and a tendency to be a heavy drinker in adulthood, in a study of adolescent rats.

5 May 2008

High-fat diet for severe childhood epilepsy prevents seizures

According to experts in Britain a high-fat diet for children with severe epilepsy can dramatically reduce or prevent seizures; seizures are caused by bursts of electrical activity in the brain.

5 May 2008

It's official - there's a rogue fat gene!

Scientists from Oxford and Cambridge say in their second discovery they have found new genetic variants that influence fat mass, weight and risk of obesity and increase the chances of being fat, which may explain why some people are always battling with their weight.

5 May 2008