Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Unc5-GPC3 complex modulates the migration of neurons and brain-derived cancer cells

During brain development, neurons have to migrate long distances through complex environments until they reach their final destination.

18 Oct 2022

New combination therapy shows potential to improve survival in children with neuroblastoma

Children who suffer a relapse of the aggressive cancer known as neuroblastoma have small chances of survival.

22 Aug 2022

New strategies to enhance the survival of children with neuroblastoma

Neuroblastoma, a childhood cancer that develops from neural cells on the adrenal glands, accounts for 15% of childhood cancer deaths. Almost half of children with high-risk neuroblastoma harbor extra copies of the gene MYCN (MYCN amplified), the primary driver of neuroblastoma and its resistance to therapy.

18 Aug 2022

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

In a study recently published in Cancer Research, a journal of the American Association for Cancer Research, a team of researchers led by C. Patrick Reynolds, M.D., Ph.D., director for the Texas Tech University Health Sciences Center School of Medicine Cancer Center, sought to expand upon his lab's previous research that showed ALT tumors identified by a biomarker known as C-circles share a common biology that confers vulnerabilities to be exploited for cancer therapy.

10 Aug 2022

CHOP helps launch new computational platform to harmonize pediatric cancer data

Children's Hospital of Philadelphia has helped launch a new computational platform that will harmonize pediatric cancer data, allowing researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.

4 Aug 2022

Novel targeted therapy may be an effective treatment option for neuroblastoma

New research from VCU Massey Cancer Center -; published Thursday in Cell Reports -; demonstrated that a novel targeted therapy could be an effective treatment option for a deadly pediatric cancer known as neuroblastoma.

28 Jul 2022

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

Effective and safe treatments are needed for medulloblastoma-;the most common type of cancerous brain tumor in children-;especially for patients whose cancer has spread to the spinal cord.

14 Jul 2022

New machine learning algorithm finds a gene signature characteristic of tumors

How do cancer cells differ from healthy cells? A new machine learning algorithm called "ikarus" knows the answer, reports a team led by MDC bioinformatician Altuna Akalin in the journal Genome Biology. The AI program has found a gene signature characteristic of tumors.

10 Jun 2022

Study confirms the benefits of 'bridge therapy' for some children with high-risk neuroblastoma

Approximately half of children with neuroblastoma-;a childhood cancer that develops from immature nerve cells-;have a form that indicates a high likelihood of recurrence.

6 Jun 2022

Children from historically marginalized groups or poor backgrounds less likely to survive neuroblastoma

Children with high-risk neuroblastoma had worse outcomes if they were from certain racial/ethnic groups or were on public rather than private insurance, despite being treated in clinical trials with standardized protocols, according to a study led by investigators from Dana-Farber/Boston Children's Cancer and Blood Disorders Center.

26 May 2022

New technique can accurately detect viruses in tumors from clinical next-generation sequencing

Researchers have developed a method to accurately detect viruses from clinical next-generation sequencing and describe novel associations between specific tumors and viruses that warrant further investigation.

5 May 2022

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Certain childhood tumors have an extreme need for amino acids. Scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg, and HI-STEM gGmbH have now discovered the molecular mechanisms underlying this and how the cancer cells could be turned off.

28 Apr 2022

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

Yale scientists uncover key regulator of body weight. Yale scientists have discovered that a protein known as augmentor-alpha regulates body weight in mice, an insight that could lead to new treatments for metabolic disorders.

11 Apr 2022

TTUHSC researcher secures $1.9 million grant to investigate vulnerabilities in ALT cancers

The National Cancer Institute, part of the National Institutes of Health, recently awarded a five-year, $ $1.9 million grant to C. Patrick Reynolds, M.D., Ph.D., director for the School of Medicine Cancer Center at the Texas Tech University Health Sciences Center.

23 Mar 2022

Potential tumor vulnerability may be exploited to improve treatment of neuroblastoma

A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths from pediatric malignancies.

7 Feb 2022

Antibody combination produces a synergistic response in difficult-to-treat pediatric cancers

A combination of anti-cancer antibodies produced a powerfully synergistic response in two hard-to-treat pediatric cancers, according to a new study, in mice, led by researchers at the Stanford University School of Medicine.

19 Jan 2022

Study reveals chromosome-level changes that relate to drug resistance in melanoma

Precision therapies targeting melanoma and other cancers have improved patient survival, but tumors often stop responding to drugs, and recent studies point to changes in DNA – both inside and outside chromosomes – as a driving factor in tumor genesis as well as in treatment resistance.

20 Dec 2021

Scientists create a new method to efficiently barcode individual cells

Scientists have developed a pioneering new technique to barcode individual cells more accurately and efficiently - which could help pave the way for quicker disease diagnosis.

18 Dec 2021

Novel monoclonal antibody could help revolutionize treatment of children with high-risk neuroblastoma

Survival rates increased about 20% for children with high-risk neuroblastoma enrolled in a St. Jude Children’s Research Hospital clinical trial that included a novel monoclonal antibody produced onsite. The findings appeared today in the Journal of Clinical Oncology.

6 Dec 2021

New combination treatment enables complete tumor regression in mice with high-risk neuroblastoma

In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study from University of Gothenburg researchers shows.

30 Nov 2021

Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Unc5-GPC3 complex modulates the migration of neurons and brain-derived cancer cells

New combination therapy shows potential to improve survival in children with neuroblastoma

New strategies to enhance the survival of children with neuroblastoma

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

CHOP helps launch new computational platform to harmonize pediatric cancer data

Novel targeted therapy may be an effective treatment option for neuroblastoma

Phase I clinical trial of new blocking antibody therapy shows promising results for the treatment of advanced medulloblastoma

New machine learning algorithm finds a gene signature characteristic of tumors

Study confirms the benefits of 'bridge therapy' for some children with high-risk neuroblastoma

Children from historically marginalized groups or poor backgrounds less likely to survive neuroblastoma

New technique can accurately detect viruses in tumors from clinical next-generation sequencing

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Discovery of key regulator of body weight could lead to new treatments for metabolic disorders

TTUHSC researcher secures $1.9 million grant to investigate vulnerabilities in ALT cancers

Potential tumor vulnerability may be exploited to improve treatment of neuroblastoma

Antibody combination produces a synergistic response in difficult-to-treat pediatric cancers

Study reveals chromosome-level changes that relate to drug resistance in melanoma

Scientists create a new method to efficiently barcode individual cells

Novel monoclonal antibody could help revolutionize treatment of children with high-risk neuroblastoma

New combination treatment enables complete tumor regression in mice with high-risk neuroblastoma

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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