Pharmacology News and Research

Latest Pharmacology News and Research

New, low-cost biosimilar for IBD therapy shows efficacy and safety

Treatment of Crohn's disease and ulcerative colitis has been greatly improved by the introduction of biologic therapies such as infliximab (which targets tumour necrosis factor alpha), but at considerable cost.

3 Mar 2017

Case Western Reserve and VA team up to tackle rising problem of antibiotic resistance

Since the discovery of penicillin in 1928, antibiotics have made the world a much safer and healthier place. But Shakespeare was onto something when he asked if it's possible to have too much of a good thing. In the case of antibiotics, the answer is increasingly "yes."

3 Mar 2017

Study provides insights into how cancer cells can evade FGFR inhibitors

A new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

2 Mar 2017

New London Major Early-Phase Contract Research Center Opened on Rare Disease Day

Richmond Pharmacology, one of the UK’s leading early-phase contract research organisations, have today opened their new research facility in London Bridge – at the site formerly known as the Guy’s Drug Research Unit. The move is a significant boost to the UK’s efforts to continue to grow as a global hub for Life Sciences, an area of strategic importance outlined in the Government’s recent industrial strategy.

1 Mar 2017

Novel non-pharmacological approach shows promise to manage chronic pain

Chronic pain afflicts over 100 million people across the United States. It diminishes their productivity and their quality of life and costs hundreds of billions of dollars each year to medically manage. It shatters people's emotional wellbeing, tears apart families and claims lives through suicides and accidental drug overdoses.

1 Mar 2017

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

Scientists at the Institute for Infectious Diseases, University of Bern have developed an in vitro stem cell-based bioassay grown on multi-electrode arrays capable of detecting the biological activity of Clostridium botulinum neurotoxins.

28 Feb 2017

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

A University of Cincinnati researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.

28 Feb 2017

NR could potentially prevent chemotherapy-induced peripheral neuropathy in cancer patients

A new study in rats suggests that nicotinamide riboside (NR), a form of vitamin B3, may be useful for treating or preventing nerve pain (neuropathy) caused by chemotherapy drugs.

24 Feb 2017

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

For the first time a "tipping point" molecular link between the blood sugar glucose and Alzheimer's disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer's.

24 Feb 2017

New analysis finds high rates of initial medication non-adherence in chronic treatments

A new analysis indicates that not obtaining a medication the first time it is prescribed-called initial medication non-adherence-is common among patients within the Catalan health system in Spain.

23 Feb 2017

Incidence of inflammatory bowel disease continues to increase in Denmark, research reveals

New research indicates that the incidence of inflammatory bowel disease-including ulcerative colitis (UC) and Crohn's disease (CD)-in Denmark is on the rise and is among the highest in the world.

23 Feb 2017

Study shows way to reverse high blood pressure in baby rats born to hypertensive mothers

Mothers contribute a lot of defining traits to their offspring, from eye color to toe length. But pregnant mothers with health complications, such as diabetes or hypertension, also can pass these symptoms to their children.

22 Feb 2017

UC San Diego researchers receive new grant to advance malaria research

An international research team, led by principal investigator Elizabeth A. Winzeler, PhD, professor in the pediatric division of host-microbe systems and therapeutics at University of California San Diego School of Medicine, and colleagues have received a three-year, $4.7 million supplemental grant from the Bill & Melinda Gates Foundation to advance their development of improved therapies for malaria eradication and elimination.

17 Feb 2017

Scientists map vast spider web of cancer proteins to reveal new drug targets

Scientists at Winship Cancer Institute of Emory University have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered "undruggable."

17 Feb 2017

SLU scientist examines potential biomarkers for pain linked to debilitating health conditions

With new funding from The Mayday Fund, a Saint Louis University researcher will leverage her discovery of a pain pathway to determine if either of two key molecules can be used as biomarkers for pain associated with four debilitating health conditions: chemotherapy-induced peripheral neuropathy, endometriosis, interstitial cystitis and vulvodynia.

16 Feb 2017

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

A component of an enzyme family linked to DNA repair, stress responses, and cancer also plays a role in enhancing or inhibiting major cellular activities under physiological conditions, new research shows.

16 Feb 2017

New test could lead to early diagnosis and effective treatment of mild traumatic brain injury

A new test using peripheral vision reaction time could lead to earlier diagnosis and more effective treatment of mild traumatic brain injury, often referred to as a concussion, according to Peter J. Bergold, PhD, professor of physiology and pharmacology at SUNY Downstate Medical Center and corresponding author of a study newly published online by the Journal of Neurotrauma.

16 Feb 2017

Neurotrophic factor GDNF regulates dopamine neurons in the brain, research shows

New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems.

15 Feb 2017

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

A father's nicotine use may have a significant impact on children's risk of some diseases. In a study published in the online biomedical sciences journal eLife, Oliver J. Rando, MD, PhD, and colleagues at UMass Medical School, demonstrate that mice born of fathers who are habitually exposed to nicotine inherit enhanced chemical tolerance and drug clearance abilities.

14 Feb 2017

Long-term use of testosterone therapy in hypogonadal men may reduce risk of death from CV disease

Despite the continued controversy surrounding the use of testosterone in men who have testosterone deficiency (hypogonadism), a new study has found that long-term use of testosterone therapy not only improves vigor and vitality, but may reduce the risk of death due to cardiovascular (CV) disease.

13 Feb 2017

Pharmacology News and Research

Latest Pharmacology News and Research

New, low-cost biosimilar for IBD therapy shows efficacy and safety

Case Western Reserve and VA team up to tackle rising problem of antibiotic resistance

Study provides insights into how cancer cells can evade FGFR inhibitors

New London Major Early-Phase Contract Research Center Opened on Rare Disease Day

Novel non-pharmacological approach shows promise to manage chronic pain

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

NR could potentially prevent chemotherapy-induced peripheral neuropathy in cancer patients

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

New analysis finds high rates of initial medication non-adherence in chronic treatments

Incidence of inflammatory bowel disease continues to increase in Denmark, research reveals

Study shows way to reverse high blood pressure in baby rats born to hypertensive mothers

UC San Diego researchers receive new grant to advance malaria research

Scientists map vast spider web of cancer proteins to reveal new drug targets

SLU scientist examines potential biomarkers for pain linked to debilitating health conditions

UT Southwestern scientists unravel role of PARP enzymes in major cellular activities

New test could lead to early diagnosis and effective treatment of mild traumatic brain injury

Neurotrophic factor GDNF regulates dopamine neurons in the brain, research shows

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

Long-term use of testosterone therapy in hypogonadal men may reduce risk of death from CV disease

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Pharmacology News and Research

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