Pharmacology News and Research

Latest Pharmacology News and Research

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Many types of cancer become drug resistant, making them difficult to treat. Researchers with University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to selectively sensitize certain cancer cells to radiation therapy that may improve tumor control and reduce treatment-related side effects.

5 Oct 2016

BUSM scientists discover new strategy to treat colon cancers driven by mutant KRAS genes

Researchers from Boston University School of Medicine have discovered a possible strategy to treat colon cancers that are caused by the mutant KRAS gene, which is responsible for approximately half of all colon cancer cases.

4 Oct 2016

Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

A Duke University-led study shows how exposure to the particulate matter from cigarette smoke may affect early development in zebrafish embryos and increases the risk of neurological disorders and physical deformities.

4 Oct 2016

UEF research shows retinal changes may be detected earlier than brain changes

Diseases of the central nervous system (CNS) may manifest as pathological changes in the retina of the eye.

3 Oct 2016

Alternative therapies appear to be effective in ameliorating IBS symptoms

A new review looks at the evidence behind the effectiveness of complementary or alternative therapies-including probiotics, prebiotics, synbiotics, fiber, and herbal medicinal products-for the treatment of bowel disorders such as irritable bowel syndrome (IBS), functional constipation, and ulcerative colitis.

3 Oct 2016

Researchers suggest need for human studies to examine effects of cannabinoid use during pregnancy

In this new era of legalized marijuana, far too little research has been conducted on the effect of cannabis on the development of human embryos, say researchers at Georgetown University Medical Center who scoured medical literature on the topic and found what they say is worrisome animal research.

30 Sep 2016

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

The Alzheimer's Drug Discovery Foundation announces a $2.1 million grant awarded to R. Scott Turner, MD, PhD, of Georgetown University Medical Center to conduct a phase II clinical trial of low-dose nilotinib (marketed as Tasigna for use as a cancer therapy) in patients with Alzheimer's disease.

29 Sep 2016

Bioactive compound from neem plant shows promising effects on prostate cancer

A team of international researchers led by Associate Professor Gautam Sethi from the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore has found that nimbolide, a bioactive terpenoid compound derived from Azadirachta indica or more commonly known as the neem plant, could reduce the size of prostate tumour by up to 70 per cent and suppress its spread or metastasis by half.

29 Sep 2016

Alcohol produces same neural and molecular changes as rapid antidepressant drugs

Can having a few drinks help people with clinical depression feel better? Yes. At least in terms of biochemistry.

28 Sep 2016

Researchers aim to discover new treatments for triple-negative breast cancer

The precision medicine approach involving DNA sequencing to pinpoint specific alterations that can be targeted with anti-cancer therapies is becoming an alternate treatment avenue for those with poor-responding cancers.

28 Sep 2016

Cross-disciplinary concepts may lead to effective, personalised cancer treatments

It is not only tumours and metastases that differ in each type of cancer and each individual sufferer but also receptors in cells.

27 Sep 2016

NIGHTSEA and EMS nominate Dr. Sarah Petersen for 2016 KEY Award

NIGHTSEA, creators and manufacturers of the innovative Stereo Microscope Fluorescence Adapter (SFA), and Electron Microscopy Sciences (EMS) are pleased to award the second annual KEY Award for New Faculty to Dr. Sarah Petersen of Kenyon College.

From NIGHTSEA 24 Sep 2016

Human pluripotent stem cells may revolutionize drug discovery in heart disease

Coaxing stem cells from patients to become heart cells may help clinicians personalize drug treatments and prevent heart-related toxicity.

20 Sep 2016

Study quantifies burden of clinically impactful ADRs in general adult population

In a study of 1000 adult patients with unplanned admission to a tertiary hospital in Singapore, the prevalence of adverse drug reactions (ADRs) at the time of admission was 12.4 percent, and the prevalence of ADRs causing admission to the hospital was 8.1 percent.

19 Sep 2016

UC Irvine study shows how YHS effectively treats different forms of pain

Root extracts from the flowering herbal plant Corydalis yanhusuo, or YHS, has widely used for centuries as a pain treatment. Yet few studies have investigated how it works on different forms of pain, and little is known about its molecular mechanisms.

14 Sep 2016

Study finds South Africans living with HIV more resilient despite chronic pain

When one thinks about chronic conditions that are commonly painful, HIV doesn't typically spring to mind. However, more than 50% of HIV-positive individuals experience a painful condition like headache, chest pain or neuropathy, and that pain is frequently experienced as moderate to severe in intensity.

14 Sep 2016

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

Triptolide molecule can turn into 'cruise missile' against cancer

More than 20 years ago, a billboard in China piqued the interest of a chemical biologist. It endorsed an extract from the plant known as the “thunder god vine” as an immunosuppressant.

9 Sep 2016

Researchers discover how immune cells transition from silent to merciless killing machines

Neutrophils are the superheroes of the body's immune system. Normally mild-mannered, they travel through the bloodstream until they reach an emergency situation, such as a cut or infection, where they switch into battle-mode to engulf and destroy foreign invaders.

9 Sep 2016

New molecular mechanism may explain pain relieving drug’s diverse benefits

Aspirin's ability to reduce the risk of both cardiovascular disease and colon cancer has been a welcome, yet puzzling, attribute of the pain reliever that has been a mainstay in medicine cabinets for more than 100 years.

7 Sep 2016

Pharmacology News and Research

Latest Pharmacology News and Research

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

BUSM scientists discover new strategy to treat colon cancers driven by mutant KRAS genes

Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

UEF research shows retinal changes may be detected earlier than brain changes

Alternative therapies appear to be effective in ameliorating IBS symptoms

Researchers suggest need for human studies to examine effects of cannabinoid use during pregnancy

ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients

Bioactive compound from neem plant shows promising effects on prostate cancer

Alcohol produces same neural and molecular changes as rapid antidepressant drugs

Researchers aim to discover new treatments for triple-negative breast cancer

Cross-disciplinary concepts may lead to effective, personalised cancer treatments

NIGHTSEA and EMS nominate Dr. Sarah Petersen for 2016 KEY Award

Human pluripotent stem cells may revolutionize drug discovery in heart disease

Study quantifies burden of clinically impactful ADRs in general adult population

UC Irvine study shows how YHS effectively treats different forms of pain

Study finds South Africans living with HIV more resilient despite chronic pain

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Triptolide molecule can turn into 'cruise missile' against cancer

Researchers discover how immune cells transition from silent to merciless killing machines

New molecular mechanism may explain pain relieving drug’s diverse benefits

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Pharmacology News and Research

Latest Pharmacology News and Research

Pittcon Highlights: Pharmaceutical & Biologic eBook

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Automating research - solutions and best practices

How can microdialysis benefit drug development

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