Pharmacology News and Research

Latest Pharmacology News and Research

Annexin A5 protein may have therapeutic potential for treatment of sepsis

Sepsis is the leading cause of in-hospital death and there is no specific treatment for it. Now, research led by Dr. Qingping Feng of Western University (London, Canada) suggests a protein called recombinant human annexin A5 may have therapeutic potential for the treatment of this disease. The paper is published in advance, online in Critical Care Medicine.

15 Nov 2013

Acquired resistance to cancer therapies: an interview with Dr Rajendra Kumari, Chief Scientific Officer at PRECOS

Cancer can be treated by a number of different ways depending on the location, grade and stage of tumour. A patient's age, medical history and lifestyle will also be taken into consideration and a combination of treatments will also be adopted to provide maximum effect.

14 Nov 2013

Research findings call for a rethinking of cancer genetics

Johns Hopkins researchers report that the deletion of any single gene in yeast cells puts pressure on the organism’s genome to compensate, leading to a mutation in another gene. Their discovery, which is likely applicable to human genetics because of the way DNA is conserved across species, could have significant consequences for the way genetic analysis is done in cancer and other areas of research, they say.

14 Nov 2013

'Quitting cold turkey' can lead to mental decline, shows study

Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Georgetown University Medical Center researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people.

13 Nov 2013

Clinical guidelines suggest BP levels in diabetes people should be kept lower than standard

Many people with diabetes also have high blood pressure. Clinical guidelines have suggested blood pressure levels in people with diabetes should be kept lower than the standard for people without diabetes. However, a new review from The Cochrane Library does not find support for this practice.

13 Nov 2013

New view can give scientists better understanding of how antidepressants work in human brain

Research from Oregon Health & Science University's Vollum Institute, published in the current issue of Nature, is giving scientists a never-before-seen view of how nerve cells communicate with each other.

13 Nov 2013

FOXO3 transcription factor may protect against alcohol-induced liver injury

New data suggest that the transcription factor FOXO3 may protect against alcohol-induced liver injury. Researchers determined that alcohol given to mice deficient in FOXO3 caused severe liver injury resembling human alcoholic hepatitis.

11 Nov 2013

Breast cancer drug appears to protect cells against UV radiation, inflammation

Exemestane, a synthetic steroid drug widely prescribed to fight breast cancers that thrive on estrogens, not only inhibits the production of the hormone, but also appears to protect cells throughout the body against damage induced by UV radiation, inflammation and other assaults, according to results of research by Johns Hopkins scientists.

8 Nov 2013

Drug formulation services for highly potent active pharmaceutical ingredients provided by Evonik

Evonik Industries has broadened its capabilities in finished drug product formulation and clinical supply manufacturing and can now handle drug products containing highly potent active pharmaceutical ingredients (HPAPIs) in Darmstadt, Germany, and Birmingham, Alabama/USA. Investments in high containment facilities and upgrades in the laboratory and GMP areas in Birmingham enable Evonik to handle HPAPIs with occupational exposure limits (OEL) as low as 0.1μg/m3 and in Darmstadt as low as 1 μg/m3. Starting 2014, OEL as low as 0.1μg/m3 will also be possible in Darmstadt.

8 Nov 2013

Volition’s NuQ-5mc assay detects 75% of patients with colorectal cancer

VolitionRx Limited, a life sciences company focused on developing blood-based diagnostic tests for different types of cancer, today announces the publication of preliminary data from an ongoing independent trial of one of its NuQ assays.

8 Nov 2013

Findings raise prospects for new therapies to protect heart from progressive disease

Some of the most commonly prescribed drugs for the treatment of heart failure are beta-blockers and nitrates, which help to relax blood vessels and decrease the heart's workload. The drugs were thought to produce those effects through distinct molecular pathways, but according to a new study led by scientists at Temple University School of Medicine, both types of drugs may help the failing heart by counteracting the effects of an enzyme known as GRK2.

8 Nov 2013

New study looks at hormone/SNS relationship in women taking hormone contraceptives

After menopause, women's levels of estrogen and progesterone fall. Their formerly lower risk for heart disease equals, even surpasses, men's risk. One possible contributing explanation for the change in risk is that sex hormones affect the sympathetic nervous system, which controls constriction of blood vessels and participates in the fight or flight response.

7 Nov 2013

New drug combination therapy effectively kills cancer cells

Results from a recent preclinical study have shown that a new drug combination therapy being developed at Virginia Commonwealth University Massey Cancer Center effectively killed colon, liver, lung, kidney, breast and brain cancer cells while having little effect on noncancerous cells. The results lay the foundation for researchers to plan a future phase 1 clinical trial to test the safety of the therapy in a small group of patients.

6 Nov 2013

Endocrine Society announces winners of organization's prestigious 2014 Laureate Awards

The Endocrine Society today announced it has selected 15 accomplished endocrinologists as winners of the organization's prestigious 2014 Laureate Awards.

5 Nov 2013

Community pharmacist program improves COPD care

Patients with chronic obstructive pulmonary disease who receive a community pharmacist-based intervention have improved inhalation technique and medication adherence, show the results of a randomized trial.

5 Nov 2013

Reviva announces successful completion of End-of-Phase 2 meeting for RP5063 drug

Reviva Pharmaceuticals, Inc., a privately held pharmaceutical company focused on the discovery and development of new, safer and highly effective therapies for chronic indications, announced today the successful completion of an End-of-Phase 2 meeting with the Food and Drug Administration for its lead, new investigational antipsychotic drug, RP5063.

5 Nov 2013

Researchers study quality, effectiveness and safety of generic drugs used to treat depression

Researchers at Washington University School of Medicine in St. Louis are studying the quality, effectiveness and safety of generic drugs used to treat depression.

4 Nov 2013

Absence of vision from birth leads to permanent state of pain hypersensitivity, shows report

Absence of vision from birth leads to a permanent state of pain hypersensitivity, reports PAIN. An international team of scientists investigated whether congenitally blind subjects experience pain differently than sighted individuals. Their results, published in the current issue of PAIN®, reveal compelling evidence that congenitally blind individuals are hypersensitive to pain caused by thermal stimuli.

3 Nov 2013

Array BioPharma reports net loss of $0.13 per share for first quarter of fiscal 2014

Array BioPharma Inc. today reported results for the first quarter of its fiscal year ending June 30, 2014.

31 Oct 2013

e-Therapeutics begins ETS6103 phase IIb trial for major depressive disorder

e-Therapeutics plc announces that it has started a randomised double-blind controlled phase IIb trial of ETS6103 in major depressive disorder.

31 Oct 2013

Pharmacology News and Research

Latest Pharmacology News and Research

Annexin A5 protein may have therapeutic potential for treatment of sepsis

Acquired resistance to cancer therapies: an interview with Dr Rajendra Kumari, Chief Scientific Officer at PRECOS

Research findings call for a rethinking of cancer genetics

'Quitting cold turkey' can lead to mental decline, shows study

Clinical guidelines suggest BP levels in diabetes people should be kept lower than standard

New view can give scientists better understanding of how antidepressants work in human brain

FOXO3 transcription factor may protect against alcohol-induced liver injury

Breast cancer drug appears to protect cells against UV radiation, inflammation

Drug formulation services for highly potent active pharmaceutical ingredients provided by Evonik

Volition’s NuQ-5mc assay detects 75% of patients with colorectal cancer

Findings raise prospects for new therapies to protect heart from progressive disease

New study looks at hormone/SNS relationship in women taking hormone contraceptives

New drug combination therapy effectively kills cancer cells

Endocrine Society announces winners of organization's prestigious 2014 Laureate Awards

Community pharmacist program improves COPD care

Reviva announces successful completion of End-of-Phase 2 meeting for RP5063 drug

Researchers study quality, effectiveness and safety of generic drugs used to treat depression

Absence of vision from birth leads to permanent state of pain hypersensitivity, shows report

Array BioPharma reports net loss of $0.13 per share for first quarter of fiscal 2014

e-Therapeutics begins ETS6103 phase IIb trial for major depressive disorder

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Pharmacology News and Research

Latest Pharmacology News and Research

Pittcon Highlights: Pharmaceutical & Biologic eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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