Pharmacology News and Research

Latest Pharmacology News and Research

Researchers find genetic switch for internal body clock

University of California, Irvine researchers have identified the chemical switch that triggers the genetic mechanism regulating our internal body clock.

13 Dec 2007

Novel technique using computer modeling identifies potential side effects of pharmaceuticals

Early identification of adverse effects of drugs before they are tested in humans is crucial in developing new therapeutics, as unexpected effects account for a third of all drug failures during the development process.

12 Dec 2007

FDA and Pharsight continue to collaborate under CRADA

Pharsight Corporation has provided an update on its Cooperative Research and Development Agreement (CRADA) with the Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER).

12 Dec 2007

New understanding of biological effects of alcohol on genes within cells

Alcohol triggers the activation of a variety of genes that can influence the health and activity of brain cells, and new research from Weill Cornell Medical College in New York City sheds light on how that process occurs.

10 Dec 2007

Depression nearly triples the risk of death following a heart attack

...even when accounting for other heart attack risk factors, according to research presented at the American College of Neuropsychopharmacology (ACNP) annual meeting, which showed that among 360 depressed, post myocardial infarction patients followed for more than six years, those who did not recover from their depression in the first six months were more than twice as likely to die.

10 Dec 2007

Genetic markers for mental illness

Researchers have discovered natural genetic differences that might help predict the most effective antipsychotic drugs for particular patients with mental disorders such as schizophrenia, Parkinson's and drug addiction.

4 Dec 2007

Perchlorate contamination of drinking water may pose a greater health risk than previously thought

Scientists at the Albert Einstein College of Medicine of Yeshiva University have shown that perchlorate - an industrial pollutant linked to thyroid ailments - is actively concentrated in breast milk.

4 Dec 2007

Neuromuscular consequences of reflexive covert orienting

The person you're speaking with may be looking at you, but are they really paying attention? Or has the person covertly shifted their attention, without moving their eyes? Dr. Brian Corneil, of the Centre for Brain and Mind at The University of Western Ontario in London, Canada has found a way of actually measuring covert attention.

2 Dec 2007

Queen's University Belfast opens new centre for cancer research

Queen's Chancellor Senator George Mitchell officially opened the University's new £25M cancer research centre aimed at stopping the spread of cancer.

29 Nov 2007

BioMarin files investigational NDA for PEG-PAL for the treatment of phenylketonuria

BioMarin Pharmaceutical Inc. has announced that it has filed an investigational new drug application (IND) with the U.S. Food and Drug Administration (FDA) for PEG-PAL (Poly Ethylene Glycol-Phenylalanine Ammonia Lyase), formerly known as Phenylase, for the treatment of phenylketonuria (PKU).

27 Nov 2007

Study of Mexican Americans shows that polymorphisms of the CYP2E1 gene enhance susceptibility to alcoholism

Mexican Americans make up 66 percent of the U.S. Hispanic population and, when compared to other ethnic groups, show high rates of heavy drinking and alcohol-related problems.

27 Nov 2007

Bortezomib pushes cancer cells into overdrive, so that they self-destruct

University of Michigan Comprehensive Cancer Center researchers have discovered that bortezomib, a promising cancer drug, is able to strike a blow against melanoma tumor cells by revving up the action of a cancer-promoting gene.

21 Nov 2007

New non-addictive pain-killers

Two University of Adelaide pharmacologists working with one the world's leading neuroscientists have helped pave the way for the development of new pain-killing drugs that are not addictive.

20 Nov 2007

New device for screening potential new drug compounds

A new device invented by researchers at the University of Virginia could save pharmaceutical companies significant time and money in screening potential new drug compounds.

19 Nov 2007

New insight into how cystatin C may lower the risk for Alzheimer's disease

For unknown reasons a protein called amyloid beta aggregates into toxic plaques in the brain, killing neurons.

19 Nov 2007

Low doses of arsenic disrupt activity of development hormone

A team of Dartmouth Medical School (DMS) researchers has determined that low doses of arsenic disrupt the activity of a hormone critical in development. The finding is further evidence that arsenic at low doses (at levels found in U.S. drinking water in some areas) can be harmful.

15 Nov 2007

Acne drug Roaccutane may disrupt serotonin production

New research has found that a drug used to treat severe forms of acne reduces the availability of the chemical serotonin, low levels of which have been linked to aggression and clinical depression.

13 Nov 2007

Trial looks at ability of insulin to limit heart-tissue damage during a heart attack

The ability of insulin to limit heart-tissue damage during a heart attack will be tested in a landmark clinical trial led by Paresh Dandona, M.D., Ph.D., University at Buffalo Distinguished Professor in the departments of Medicine and Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences.

13 Nov 2007

Inflammation causes insulin resistance not obesity

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes.

6 Nov 2007

Fat cells release a protein that aids insulin secretion from pancreatic beta cells

The body's fat cells help the pancreas do its job of secreting insulin, according to research at Washington University School of Medicine in St. Louis.

6 Nov 2007