Pharmacology News and Research

Latest Pharmacology News and Research

Novel informatics tool helps predict genomic features associated with specific drug responses

The rise of genomics, the shift from considering genes singly to collectively, is adding a new dimension to medical care; biomedical researchers hope to use the information contained in human genomes to make better predictions about individual health, including responses to therapeutic drugs.

12 Jul 2018

Researchers elucidate role of mutations in deadly brain cancer

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have discovered how different mutations in a specific gene help drive glioblastoma, the most lethal form of brain cancer.

11 Jul 2018

Newly discovered nanobody holds promise to advance targeted therapies for several diseases

Researchers from Case Western Reserve University School of Medicine have found a nanobody that holds promise to advance targeted therapies for a number of neurological diseases and cancer.

10 Jul 2018

Researchers use x-ray crystallography to reveal how curcumin inhibits cancer

Through x-ray crystallography and kinase-inhibitor specificity profiling, University of California San Diego School of Medicine researchers, in collaboration with researchers at Peking University and Zhejiang University, reveal that curcumin, a natural occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 at the atomic level.

10 Jul 2018

New technique paves way for safer medicines without side effects

A new technique for precisely targeting molecules within cells is paving the way for safer medicines that are free of side effects.

9 Jul 2018

Fourth-generation retinoid may have improved efficacy and safety profile to treat acne

Topical retinoids, which target retinoic acid receptors, are commonly used to treat acne. New research published in theBritish Journal of Dermatologyreveals that trifarotene, a fourth-generation retinoid with potent and selective activity against only one particular retinoic acid receptor, may have an improved efficacy and safety profile compared with less selective retinoids.

6 Jul 2018

Researchers discover genetic marker associated with salt sensitivity of blood pressure

For the first time researchers have identified a genetic marker (GNAI2) that is associated with the risk of salt sensitivity in blood pressure regardless of age or gender.

5 Jul 2018

Innovative synthetic technique opens door to new world of cutting-edge medicinal compounds

In pharmacology, not all molecular structures are created equal. Some frameworks are overrepresented in nature, making them especially attractive to scientists on the hunt for more effective drugs.

4 Jul 2018

New method separates circulating tumor cells from blood samples using sound waves

Using sound waves, an international team of researchers has developed a gentle, contact-free method for separating circulating tumor cells from blood samples that is fast and efficient enough for clinical use.

3 Jul 2018

Finnish researchers gain new insights on brain activity during general anesthesia

Finnish researchers have gained new information on brain activity during general anesthesia by recording changes in the electrical activity of the brain.

3 Jul 2018

Low-dose aspirin may reduce amyloid plaques in the brain, study shows

A regimen of low-dose aspirin potentially may reduce plaques in the brain, which will reduce Alzheimer's disease pathology and protect memory, according to neurological researchers at Rush University Medical Center, who published the results of their study today in the July issue of The Journal of Neuroscience.

2 Jul 2018

Clinical judgment of doctors not reliable to predict MRH in older adults post-hospital discharge

Medication-related harm is common in older adults following hospital discharge. A new British Journal of Clinical Pharmacology study has examined whether doctors can predict which older patients will experience MRH requiring care following hospital discharge, and whether clinical experience and confidence in prediction influence the accuracy of predictions.

2 Jul 2018

New Rekovelle analysis shows AMH is robust predictor of ovarian response to fertility treatment

Ferring Pharmaceuticals announced today a new analysis of data from the Phase 3 ESTHER-1 trial showing that natural variations in anti-Müllerian hormone levels during and between a woman's menstrual cycle have no clinically relevant impact on ovarian response when using AMH to dose Rekovelle for ovarian stimulation.

2 Jul 2018

New therapeutic may help drug addicts avoid future drug use

A new therapeutic may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use.

30 Jun 2018

Researchers reveal complexity of NMDA receptor drug discovery target

Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression.

28 Jun 2018

LUMICKS partners with AstraZeneca, University of Cambridge to establish new 'Center of Excellence for Dynamic Single-Molecule Analysis for Accelerated Drug Discovery and Biology'

The center will be based around LUMICKS’ C-Trap™ optical tweezers–fluorescence microscope, which for the first time enables real-time observation and probing of biomolecular interactions. The approach will be pioneered in several pharmacology and biology assays with the aim of accelerating the discovery of potential new drugs.

From Lumicks 28 Jun 2018

Scientists discover protein crucial for activating inflammation

Researchers from the University of Illinois at Chicago have identified a protein that is crucial for activating inflammation -; both the good kind of inflammation that leads to healing wounds and fighting infection, as well as excessive inflammation where the immune system can damage tissues and organs.

27 Jun 2018

Study details role of dopamine in unlearning fear

Researchers at the RIKEN Center for Brain Science have discovered a circuit in the brain that is necessary for unlearning fear. Published in Nature Communications, the study details the role of dopamine in ensuring that rats stop being afraid when there isn't anything to be afraid of anymore.

27 Jun 2018

New nuclear medicine approach shows potential for precision treatment of solid tumors

A novel nuclear medicine approach is showing great promise for precision treatment of solid tumors in many types of cancer--including lung, breast, pancreas and ovarian in adults and glioma, neuroblastoma and sarcoma in children.

26 Jun 2018

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells-- known as the PI3 kinase (PI3K) pathway--but efforts to develop therapies targeting this pathway have met with little success after hundreds of mostly failed clinical trials. And researchers still don't understand why.

26 Jun 2018

Pharmacology News and Research

Latest Pharmacology News and Research

Novel informatics tool helps predict genomic features associated with specific drug responses

Researchers elucidate role of mutations in deadly brain cancer

Newly discovered nanobody holds promise to advance targeted therapies for several diseases

Researchers use x-ray crystallography to reveal how curcumin inhibits cancer

New technique paves way for safer medicines without side effects

Fourth-generation retinoid may have improved efficacy and safety profile to treat acne

Researchers discover genetic marker associated with salt sensitivity of blood pressure

Innovative synthetic technique opens door to new world of cutting-edge medicinal compounds

New method separates circulating tumor cells from blood samples using sound waves

Finnish researchers gain new insights on brain activity during general anesthesia

Low-dose aspirin may reduce amyloid plaques in the brain, study shows

Clinical judgment of doctors not reliable to predict MRH in older adults post-hospital discharge

New Rekovelle analysis shows AMH is robust predictor of ovarian response to fertility treatment

New therapeutic may help drug addicts avoid future drug use

Researchers reveal complexity of NMDA receptor drug discovery target

LUMICKS partners with AstraZeneca, University of Cambridge to establish new 'Center of Excellence for Dynamic Single-Molecule Analysis for Accelerated Drug Discovery and Biology'

Scientists discover protein crucial for activating inflammation

Study details role of dopamine in unlearning fear

New nuclear medicine approach shows potential for precision treatment of solid tumors

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

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Pharmacology News and Research

Latest Pharmacology News and Research

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How can microdialysis benefit drug development

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